Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1
In the present study, we have investigated the effects of centrally administered ginsenoside Rc and Rg1 on the modulation of the NMDA receptor and GABAAreceptor binding in rat brain. The NMDA receptor binding was analysed by quantitative autoradiography using [3H]MK-801 binding, and the GABAArecepto...
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| Veröffentlicht in: | Pharmacological research 2001-05, Vol.43 (5), p.473-479 |
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| creator | Kim, Hack-Seang Hwang, Seong-Lok Nah, Seung-Yeol Oh, Seikwan |
| description | In the present study, we have investigated the effects of centrally administered ginsenoside Rc and Rg1 on the modulation of the NMDA receptor and GABAAreceptor binding in rat brain. The NMDA receptor binding was analysed by quantitative autoradiography using [3H]MK-801 binding, and the GABAAreceptor bindings were analysed by using [3H]muscimol and [3H]flunitrazepam binding in rat brain slices. Rats were infused with ginsenoside Rc or Rg1 (10 μ g/10 μ l h−1, i.c.v.) for 7 days, through pre-implanted cannula using osmotic minipumps (Alzet, model 2ML). The levels of [3H]MK-801 binding were highly decreased in part of the parietal layers of the cortex and cingulated by ginsenoside Rc and Rg1. The levels of [3H]muscimol binding were strongly elevated in almost all regions of the frontal cortex by the treatment of ginsenoside Rc but decreased by ginsenoside Rg1. However, the [3H]flunitrazepam binding was not modulated by ginsenoside Rc or Rg1 infusion. These results suggest that prolonged infusion of ginsenosides could differentially modulate [3H]MK-801 and [3H]muscimol binding in a region-specific manner. |
| doi_str_mv | 10.1006/phrs.2001.0809 |
| format | Article |
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The NMDA receptor binding was analysed by quantitative autoradiography using [3H]MK-801 binding, and the GABAAreceptor bindings were analysed by using [3H]muscimol and [3H]flunitrazepam binding in rat brain slices. Rats were infused with ginsenoside Rc or Rg1 (10 μ g/10 μ l h−1, i.c.v.) for 7 days, through pre-implanted cannula using osmotic minipumps (Alzet, model 2ML). The levels of [3H]MK-801 binding were highly decreased in part of the parietal layers of the cortex and cingulated by ginsenoside Rc and Rg1. The levels of [3H]muscimol binding were strongly elevated in almost all regions of the frontal cortex by the treatment of ginsenoside Rc but decreased by ginsenoside Rg1. However, the [3H]flunitrazepam binding was not modulated by ginsenoside Rc or Rg1 infusion. These results suggest that prolonged infusion of ginsenosides could differentially modulate [3H]MK-801 and [3H]muscimol binding in a region-specific manner.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1006/phrs.2001.0809</identifier><identifier>PMID: 11394940</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Autoradiography ; Binding, Competitive - drug effects ; Brain - drug effects ; Brain - metabolism ; Dizocilpine Maleate - pharmacokinetics ; Excitatory Amino Acid Antagonists - pharmacokinetics ; Flunitrazepam - pharmacokinetics ; GABA Agonists - pharmacokinetics ; GABA Modulators - pharmacokinetics ; ginsenoside, autoradiography, NMDA receptor, GABAAreceptor ; Ginsenosides ; Injections, Intraventricular ; Male ; Muscimol - pharmacokinetics ; Panax - chemistry ; Plants, Medicinal ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA-A - drug effects ; Receptors, GABA-A - metabolism ; Receptors, N-Methyl-D-Aspartate - drug effects ; Receptors, N-Methyl-D-Aspartate - metabolism ; Saponins - administration & dosage ; Saponins - pharmacology</subject><ispartof>Pharmacological research, 2001-05, Vol.43 (5), p.473-479</ispartof><rights>2001 Academic Press</rights><rights>Copyright 2001 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-2dc6e13d9d255fd2bea4c9f09eabf08791d7609fb99887085b4111c9a0eb0b233</citedby><cites>FETCH-LOGICAL-c406t-2dc6e13d9d255fd2bea4c9f09eabf08791d7609fb99887085b4111c9a0eb0b233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1043661801908096$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11394940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hack-Seang</creatorcontrib><creatorcontrib>Hwang, Seong-Lok</creatorcontrib><creatorcontrib>Nah, Seung-Yeol</creatorcontrib><creatorcontrib>Oh, Seikwan</creatorcontrib><title>Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>In the present study, we have investigated the effects of centrally administered ginsenoside Rc and Rg1 on the modulation of the NMDA receptor and GABAAreceptor binding in rat brain. The NMDA receptor binding was analysed by quantitative autoradiography using [3H]MK-801 binding, and the GABAAreceptor bindings were analysed by using [3H]muscimol and [3H]flunitrazepam binding in rat brain slices. Rats were infused with ginsenoside Rc or Rg1 (10 μ g/10 μ l h−1, i.c.v.) for 7 days, through pre-implanted cannula using osmotic minipumps (Alzet, model 2ML). The levels of [3H]MK-801 binding were highly decreased in part of the parietal layers of the cortex and cingulated by ginsenoside Rc and Rg1. The levels of [3H]muscimol binding were strongly elevated in almost all regions of the frontal cortex by the treatment of ginsenoside Rc but decreased by ginsenoside Rg1. However, the [3H]flunitrazepam binding was not modulated by ginsenoside Rc or Rg1 infusion. These results suggest that prolonged infusion of ginsenosides could differentially modulate [3H]MK-801 and [3H]muscimol binding in a region-specific manner.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Binding, Competitive - drug effects</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Dizocilpine Maleate - pharmacokinetics</subject><subject>Excitatory Amino Acid Antagonists - pharmacokinetics</subject><subject>Flunitrazepam - pharmacokinetics</subject><subject>GABA Agonists - pharmacokinetics</subject><subject>GABA Modulators - pharmacokinetics</subject><subject>ginsenoside, autoradiography, NMDA receptor, GABAAreceptor</subject><subject>Ginsenosides</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Muscimol - pharmacokinetics</subject><subject>Panax - chemistry</subject><subject>Plants, Medicinal</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, GABA-A - drug effects</subject><subject>Receptors, GABA-A - metabolism</subject><subject>Receptors, N-Methyl-D-Aspartate - drug effects</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>Saponins - administration & dosage</subject><subject>Saponins - pharmacology</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU-P0zAQxS0EYpeFK0fkEydSZpI0tY-oWljEIqQVnBCy_GfcGiVOsZOVlg_BZ8ZpK3HiNE-jn9-M5zH2EmGFAN3bwz7lVQ2AKxAgH7FLBNlViKJ7vOi2qboOxQV7lvNPAJAtwlN2gdjIVrZwyf5s9zruKPPR8-_NzY_PnyoB-OaohznbMIw919EdG76fY5iS_k0HPXATogtxx0PkSU_cJF2UeeDTnvghjf1YfB2_pzilYOdep0L6OYcxLsN2IWaKYw6O-J09jrjb4XP2xOs-04tzvWLf3l9_3d5Ut18-fNy-u61sC91U1c52hI2Trl6vvasN6dZKD5K08SA2Et2mA-mNlEJsQKxNi4hWaiADpm6aK_b65FsW_TVTntQQsqW-15HGOasNSKhBygKuTqBNY86JvDqkMOj0oBDUkoBaElBLAmpJoDx4dXaezUDuH34-eQHECaDyv_tASZUrU7TkQiI7KTeG_3n_BbqZlak</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>Kim, Hack-Seang</creator><creator>Hwang, Seong-Lok</creator><creator>Nah, Seung-Yeol</creator><creator>Oh, Seikwan</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010501</creationdate><title>Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1</title><author>Kim, Hack-Seang ; Hwang, Seong-Lok ; Nah, Seung-Yeol ; Oh, Seikwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-2dc6e13d9d255fd2bea4c9f09eabf08791d7609fb99887085b4111c9a0eb0b233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Autoradiography</topic><topic>Binding, Competitive - drug effects</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Dizocilpine Maleate - pharmacokinetics</topic><topic>Excitatory Amino Acid Antagonists - pharmacokinetics</topic><topic>Flunitrazepam - pharmacokinetics</topic><topic>GABA Agonists - pharmacokinetics</topic><topic>GABA Modulators - pharmacokinetics</topic><topic>ginsenoside, autoradiography, NMDA receptor, GABAAreceptor</topic><topic>Ginsenosides</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Muscimol - pharmacokinetics</topic><topic>Panax - chemistry</topic><topic>Plants, Medicinal</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Receptors, GABA-A - metabolism</topic><topic>Receptors, N-Methyl-D-Aspartate - drug effects</topic><topic>Receptors, N-Methyl-D-Aspartate - metabolism</topic><topic>Saponins - administration & dosage</topic><topic>Saponins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hack-Seang</creatorcontrib><creatorcontrib>Hwang, Seong-Lok</creatorcontrib><creatorcontrib>Nah, Seung-Yeol</creatorcontrib><creatorcontrib>Oh, Seikwan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hack-Seang</au><au>Hwang, Seong-Lok</au><au>Nah, Seung-Yeol</au><au>Oh, Seikwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>43</volume><issue>5</issue><spage>473</spage><epage>479</epage><pages>473-479</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>In the present study, we have investigated the effects of centrally administered ginsenoside Rc and Rg1 on the modulation of the NMDA receptor and GABAAreceptor binding in rat brain. The NMDA receptor binding was analysed by quantitative autoradiography using [3H]MK-801 binding, and the GABAAreceptor bindings were analysed by using [3H]muscimol and [3H]flunitrazepam binding in rat brain slices. Rats were infused with ginsenoside Rc or Rg1 (10 μ g/10 μ l h−1, i.c.v.) for 7 days, through pre-implanted cannula using osmotic minipumps (Alzet, model 2ML). The levels of [3H]MK-801 binding were highly decreased in part of the parietal layers of the cortex and cingulated by ginsenoside Rc and Rg1. The levels of [3H]muscimol binding were strongly elevated in almost all regions of the frontal cortex by the treatment of ginsenoside Rc but decreased by ginsenoside Rg1. However, the [3H]flunitrazepam binding was not modulated by ginsenoside Rc or Rg1 infusion. These results suggest that prolonged infusion of ginsenosides could differentially modulate [3H]MK-801 and [3H]muscimol binding in a region-specific manner.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>11394940</pmid><doi>10.1006/phrs.2001.0809</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Autoradiography Binding, Competitive - drug effects Brain - drug effects Brain - metabolism Dizocilpine Maleate - pharmacokinetics Excitatory Amino Acid Antagonists - pharmacokinetics Flunitrazepam - pharmacokinetics GABA Agonists - pharmacokinetics GABA Modulators - pharmacokinetics ginsenoside, autoradiography, NMDA receptor, GABAAreceptor Ginsenosides Injections, Intraventricular Male Muscimol - pharmacokinetics Panax - chemistry Plants, Medicinal Rats Rats, Sprague-Dawley Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - metabolism Saponins - administration & dosage Saponins - pharmacology |
| title | Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1 |
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