Effect of verapamil on long-term tachycardia-induced atrial electrical remodeling
The effect of verapamil on long-term tachycardia-induced atrial electrical remodeling has not been reported. Forty-eight dogs were randomly divided into verapamil and control groups. The dogs in the verapamil group received verapamil 120 mg every day, those in the control group did not receive verap...
Gespeichert in:
| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2000-01, Vol.101 (2), p.200-206 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 206 |
|---|---|
| container_issue | 2 |
| container_start_page | 200 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 101 |
| creator | LEE, S.-H YU, W.-C CHENG, J.-J HUNG, C.-R DING, Y.-A CHANG, M.-S CHEN, S.-A |
| description | The effect of verapamil on long-term tachycardia-induced atrial electrical remodeling has not been reported.
Forty-eight dogs were randomly divided into verapamil and control groups. The dogs in the verapamil group received verapamil 120 mg every day, those in the control group did not receive verapamil. Atrial effective refractory period (AERP), inducibility of atrial fibrillation (AF), and duration of AF were assessed before and after complete atrioventricular junction ablation with 1-day, 1-week, or 6-week rapid atrial pacing (780 bpm). AERP shortening, AERP dispersion, AERP maladaptation, and inducibility of AF after 1-day pacing was significantly attenuated by verapamil. However, verapamil did not have any significant effect on these parameters in the dogs with 1-week or 6-week pacing. Verapamil did not have any significant effect on the conduction velocity in the dogs with 1-day, 1-week, or 6-week pacing. Before rapid atrial pacing, verapamil significantly prolonged the duration of AF. In the dogs with 1-day pacing, the duration of AF measured immediately after termination of pacing was similar between the control and verapamil groups. However, in the dogs with 1-week or 6-week pacing, the duration of AF after pacing was significantly longer in the verapamil group.
Verapamil cannot prevent long-term (1 and 6 weeks, respectively) tachycardia-induced changes of atrial electrophysiological properties. Furthermore, verapamil increases the duration of AF in the dogs either before or after long-term rapid atrial pacing. |
| doi_str_mv | 10.1161/01.cir.101.2.200 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70901738</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>49827078</sourcerecordid><originalsourceid>FETCH-LOGICAL-c500t-a52a6a66f8857577abd7c44dd59757c1cc5cf0704cebb1ff3772ede83ed19d3d3</originalsourceid><addsrcrecordid>eNpdkM1LAzEUxIMoWqt3T7KIeNv6kmw2u0cp9QMKoug5pMmLRvajJruC_70pLSie3gz8ZngMIWcUZpSW9BrozPgwo-myGQPYIxMqWJEXgtf7ZAIAdS45Y0fkOMaPZEsuxSE5ohvBoJ6Qp4VzaIasd9kXBr3WrW-yvsuavnvLBwxtNmjz_m10sF7nvrOjQZvpIXjdZNikaPAmyYBtb7Hx3dsJOXC6iXi6u1Pyert4md_ny8e7h_nNMjcCYMi1YLrUZemqSkghpV5ZaYrCWlEna6gxwjiQUBhcrahzXEqGFiuOltaWWz4lV9vedeg_R4yDan002DS6w36MSkINVPIqgRf_wI9-DF36TTHKygqgKhMEW8iEPsaATq2Db3X4VhTUZmsFVM0fnpOliqm0dYqc73rHVYv2T2A7bgIud4COaSMXdGd8_OUYrzmr-Q_jWocX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>212680086</pqid></control><display><type>article</type><title>Effect of verapamil on long-term tachycardia-induced atrial electrical remodeling</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Journals@Ovid Complete</source><creator>LEE, S.-H ; YU, W.-C ; CHENG, J.-J ; HUNG, C.-R ; DING, Y.-A ; CHANG, M.-S ; CHEN, S.-A</creator><creatorcontrib>LEE, S.-H ; YU, W.-C ; CHENG, J.-J ; HUNG, C.-R ; DING, Y.-A ; CHANG, M.-S ; CHEN, S.-A</creatorcontrib><description>The effect of verapamil on long-term tachycardia-induced atrial electrical remodeling has not been reported.
Forty-eight dogs were randomly divided into verapamil and control groups. The dogs in the verapamil group received verapamil 120 mg every day, those in the control group did not receive verapamil. Atrial effective refractory period (AERP), inducibility of atrial fibrillation (AF), and duration of AF were assessed before and after complete atrioventricular junction ablation with 1-day, 1-week, or 6-week rapid atrial pacing (780 bpm). AERP shortening, AERP dispersion, AERP maladaptation, and inducibility of AF after 1-day pacing was significantly attenuated by verapamil. However, verapamil did not have any significant effect on these parameters in the dogs with 1-week or 6-week pacing. Verapamil did not have any significant effect on the conduction velocity in the dogs with 1-day, 1-week, or 6-week pacing. Before rapid atrial pacing, verapamil significantly prolonged the duration of AF. In the dogs with 1-day pacing, the duration of AF measured immediately after termination of pacing was similar between the control and verapamil groups. However, in the dogs with 1-week or 6-week pacing, the duration of AF after pacing was significantly longer in the verapamil group.
Verapamil cannot prevent long-term (1 and 6 weeks, respectively) tachycardia-induced changes of atrial electrophysiological properties. Furthermore, verapamil increases the duration of AF in the dogs either before or after long-term rapid atrial pacing.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.cir.101.2.200</identifier><identifier>PMID: 10637209</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adaptation, Physiological ; Animals ; Atrial Function ; Biological and medical sciences ; Calcium Channel Blockers - pharmacology ; Cardiac dysrhythmias ; Cardiac Pacing, Artificial ; Cardiology. Vascular system ; Chronic Disease ; Dogs ; Electrophysiology ; Female ; Heart ; Heart Conduction System - physiopathology ; Male ; Medical sciences ; Neural Conduction ; Refractory Period, Electrophysiological ; Tachycardia - physiopathology ; Time Factors ; Verapamil - pharmacology</subject><ispartof>Circulation (New York, N.Y.), 2000-01, Vol.101 (2), p.200-206</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jan 18, 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-a52a6a66f8857577abd7c44dd59757c1cc5cf0704cebb1ff3772ede83ed19d3d3</citedby><cites>FETCH-LOGICAL-c500t-a52a6a66f8857577abd7c44dd59757c1cc5cf0704cebb1ff3772ede83ed19d3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1239329$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10637209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEE, S.-H</creatorcontrib><creatorcontrib>YU, W.-C</creatorcontrib><creatorcontrib>CHENG, J.-J</creatorcontrib><creatorcontrib>HUNG, C.-R</creatorcontrib><creatorcontrib>DING, Y.-A</creatorcontrib><creatorcontrib>CHANG, M.-S</creatorcontrib><creatorcontrib>CHEN, S.-A</creatorcontrib><title>Effect of verapamil on long-term tachycardia-induced atrial electrical remodeling</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>The effect of verapamil on long-term tachycardia-induced atrial electrical remodeling has not been reported.
Forty-eight dogs were randomly divided into verapamil and control groups. The dogs in the verapamil group received verapamil 120 mg every day, those in the control group did not receive verapamil. Atrial effective refractory period (AERP), inducibility of atrial fibrillation (AF), and duration of AF were assessed before and after complete atrioventricular junction ablation with 1-day, 1-week, or 6-week rapid atrial pacing (780 bpm). AERP shortening, AERP dispersion, AERP maladaptation, and inducibility of AF after 1-day pacing was significantly attenuated by verapamil. However, verapamil did not have any significant effect on these parameters in the dogs with 1-week or 6-week pacing. Verapamil did not have any significant effect on the conduction velocity in the dogs with 1-day, 1-week, or 6-week pacing. Before rapid atrial pacing, verapamil significantly prolonged the duration of AF. In the dogs with 1-day pacing, the duration of AF measured immediately after termination of pacing was similar between the control and verapamil groups. However, in the dogs with 1-week or 6-week pacing, the duration of AF after pacing was significantly longer in the verapamil group.
Verapamil cannot prevent long-term (1 and 6 weeks, respectively) tachycardia-induced changes of atrial electrophysiological properties. Furthermore, verapamil increases the duration of AF in the dogs either before or after long-term rapid atrial pacing.</description><subject>Adaptation, Physiological</subject><subject>Animals</subject><subject>Atrial Function</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardiology. Vascular system</subject><subject>Chronic Disease</subject><subject>Dogs</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Conduction System - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neural Conduction</subject><subject>Refractory Period, Electrophysiological</subject><subject>Tachycardia - physiopathology</subject><subject>Time Factors</subject><subject>Verapamil - pharmacology</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1LAzEUxIMoWqt3T7KIeNv6kmw2u0cp9QMKoug5pMmLRvajJruC_70pLSie3gz8ZngMIWcUZpSW9BrozPgwo-myGQPYIxMqWJEXgtf7ZAIAdS45Y0fkOMaPZEsuxSE5ohvBoJ6Qp4VzaIasd9kXBr3WrW-yvsuavnvLBwxtNmjz_m10sF7nvrOjQZvpIXjdZNikaPAmyYBtb7Hx3dsJOXC6iXi6u1Pyert4md_ny8e7h_nNMjcCYMi1YLrUZemqSkghpV5ZaYrCWlEna6gxwjiQUBhcrahzXEqGFiuOltaWWz4lV9vedeg_R4yDan002DS6w36MSkINVPIqgRf_wI9-DF36TTHKygqgKhMEW8iEPsaATq2Db3X4VhTUZmsFVM0fnpOliqm0dYqc73rHVYv2T2A7bgIud4COaSMXdGd8_OUYrzmr-Q_jWocX</recordid><startdate>20000118</startdate><enddate>20000118</enddate><creator>LEE, S.-H</creator><creator>YU, W.-C</creator><creator>CHENG, J.-J</creator><creator>HUNG, C.-R</creator><creator>DING, Y.-A</creator><creator>CHANG, M.-S</creator><creator>CHEN, S.-A</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20000118</creationdate><title>Effect of verapamil on long-term tachycardia-induced atrial electrical remodeling</title><author>LEE, S.-H ; YU, W.-C ; CHENG, J.-J ; HUNG, C.-R ; DING, Y.-A ; CHANG, M.-S ; CHEN, S.-A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-a52a6a66f8857577abd7c44dd59757c1cc5cf0704cebb1ff3772ede83ed19d3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adaptation, Physiological</topic><topic>Animals</topic><topic>Atrial Function</topic><topic>Biological and medical sciences</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cardiology. Vascular system</topic><topic>Chronic Disease</topic><topic>Dogs</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Conduction System - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neural Conduction</topic><topic>Refractory Period, Electrophysiological</topic><topic>Tachycardia - physiopathology</topic><topic>Time Factors</topic><topic>Verapamil - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEE, S.-H</creatorcontrib><creatorcontrib>YU, W.-C</creatorcontrib><creatorcontrib>CHENG, J.-J</creatorcontrib><creatorcontrib>HUNG, C.-R</creatorcontrib><creatorcontrib>DING, Y.-A</creatorcontrib><creatorcontrib>CHANG, M.-S</creatorcontrib><creatorcontrib>CHEN, S.-A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEE, S.-H</au><au>YU, W.-C</au><au>CHENG, J.-J</au><au>HUNG, C.-R</au><au>DING, Y.-A</au><au>CHANG, M.-S</au><au>CHEN, S.-A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of verapamil on long-term tachycardia-induced atrial electrical remodeling</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2000-01-18</date><risdate>2000</risdate><volume>101</volume><issue>2</issue><spage>200</spage><epage>206</epage><pages>200-206</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>The effect of verapamil on long-term tachycardia-induced atrial electrical remodeling has not been reported.
Forty-eight dogs were randomly divided into verapamil and control groups. The dogs in the verapamil group received verapamil 120 mg every day, those in the control group did not receive verapamil. Atrial effective refractory period (AERP), inducibility of atrial fibrillation (AF), and duration of AF were assessed before and after complete atrioventricular junction ablation with 1-day, 1-week, or 6-week rapid atrial pacing (780 bpm). AERP shortening, AERP dispersion, AERP maladaptation, and inducibility of AF after 1-day pacing was significantly attenuated by verapamil. However, verapamil did not have any significant effect on these parameters in the dogs with 1-week or 6-week pacing. Verapamil did not have any significant effect on the conduction velocity in the dogs with 1-day, 1-week, or 6-week pacing. Before rapid atrial pacing, verapamil significantly prolonged the duration of AF. In the dogs with 1-day pacing, the duration of AF measured immediately after termination of pacing was similar between the control and verapamil groups. However, in the dogs with 1-week or 6-week pacing, the duration of AF after pacing was significantly longer in the verapamil group.
Verapamil cannot prevent long-term (1 and 6 weeks, respectively) tachycardia-induced changes of atrial electrophysiological properties. Furthermore, verapamil increases the duration of AF in the dogs either before or after long-term rapid atrial pacing.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10637209</pmid><doi>10.1161/01.cir.101.2.200</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2000-01, Vol.101 (2), p.200-206 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70901738 |
| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Adaptation, Physiological Animals Atrial Function Biological and medical sciences Calcium Channel Blockers - pharmacology Cardiac dysrhythmias Cardiac Pacing, Artificial Cardiology. Vascular system Chronic Disease Dogs Electrophysiology Female Heart Heart Conduction System - physiopathology Male Medical sciences Neural Conduction Refractory Period, Electrophysiological Tachycardia - physiopathology Time Factors Verapamil - pharmacology |
| title | Effect of verapamil on long-term tachycardia-induced atrial electrical remodeling |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T01%3A00%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20verapamil%20on%20long-term%20tachycardia-induced%20atrial%20electrical%20remodeling&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=LEE,%20S.-H&rft.date=2000-01-18&rft.volume=101&rft.issue=2&rft.spage=200&rft.epage=206&rft.pages=200-206&rft.issn=0009-7322&rft.eissn=1524-4539&rft.coden=CIRCAZ&rft_id=info:doi/10.1161/01.cir.101.2.200&rft_dat=%3Cproquest_cross%3E49827078%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=212680086&rft_id=info:pmid/10637209&rfr_iscdi=true |