Protein S-100B: A Serum Marker for Ischemic and Infectious Injury of Cerebral Tissue

The S-100B protein is released by injured astrocytes. After passage through a disintegrated blood-brain barrier (BBB) the molecule can be detected in the peripheral circulation. We investigated the association between the extent of brain injury and S-100B concentration in serum in cerebral injury ca...

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Veröffentlicht in:Clinical chemistry and laboratory medicine 2001-04, Vol.39 (4), p.319-323
Hauptverfasser: Bertsch, Thomas, Casarin, Wendy, Kretschmar, Marianne, Zimmer, Wilma, Walter, Silke, Sommer, Clemens, Muehlhauser, Frank, Ragoschke, Andreas, Kuehl, Sandra, Schmidt, Roland, Pohlmann-Eden, Bernd, Nassabi, Claudius, Nichterlein, Thomas, Faßbender, Klaus
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container_end_page 323
container_issue 4
container_start_page 319
container_title Clinical chemistry and laboratory medicine
container_volume 39
creator Bertsch, Thomas
Casarin, Wendy
Kretschmar, Marianne
Zimmer, Wilma
Walter, Silke
Sommer, Clemens
Muehlhauser, Frank
Ragoschke, Andreas
Kuehl, Sandra
Schmidt, Roland
Pohlmann-Eden, Bernd
Nassabi, Claudius
Nichterlein, Thomas
Faßbender, Klaus
description The S-100B protein is released by injured astrocytes. After passage through a disintegrated blood-brain barrier (BBB) the molecule can be detected in the peripheral circulation. We investigated the association between the extent of brain injury and S-100B concentration in serum in cerebral injury caused by cerebral ischemia and cerebral fungal infection. Study I: The S-100B serum concentration was serially determined in 24 patients with ischemic stroke at 4, 8, 10, 24, 72 hours after the onset of symptoms. We observed that patients with brain lesions larger than 5 cm3 exhibited significantly increased serum levels of S-100B at 10, 24 and 72 hours compared to those with lesion volumes below 5 cm3. Furthermore, an association between S-100B serum concentration and neurological outcome was observed. Study II: In a mouse model of systemic fungal infection with Candida albicans we observed that serum levels of S-100B increased at day 1 after intravenous infection. At this time we could histologically demonstrate brain tissue injury by invading hyphae which had crossed the BBB. Furthermore, reactive astrogliosis was demonstrated by immunohistochemistry. On day 7 we found a significant decrease of S-100B serum level compared to day 1 and 4. This was associated with a demarcation of the fungi with leukocytes in brain tissue at this late phase of infection. No further invasion through the BBB was seen on day 7. In conclusion, serum levels of S-100B reflect the time course of tissue injury in cerebral ischemia and cerebral infection to a similar extent. Thus, S-100B may be a useful marker to assess cerebral tissue injury.
doi_str_mv 10.1515/CCLM.2001.050
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After passage through a disintegrated blood-brain barrier (BBB) the molecule can be detected in the peripheral circulation. We investigated the association between the extent of brain injury and S-100B concentration in serum in cerebral injury caused by cerebral ischemia and cerebral fungal infection. Study I: The S-100B serum concentration was serially determined in 24 patients with ischemic stroke at 4, 8, 10, 24, 72 hours after the onset of symptoms. We observed that patients with brain lesions larger than 5 cm3 exhibited significantly increased serum levels of S-100B at 10, 24 and 72 hours compared to those with lesion volumes below 5 cm3. Furthermore, an association between S-100B serum concentration and neurological outcome was observed. Study II: In a mouse model of systemic fungal infection with Candida albicans we observed that serum levels of S-100B increased at day 1 after intravenous infection. At this time we could histologically demonstrate brain tissue injury by invading hyphae which had crossed the BBB. Furthermore, reactive astrogliosis was demonstrated by immunohistochemistry. On day 7 we found a significant decrease of S-100B serum level compared to day 1 and 4. This was associated with a demarcation of the fungi with leukocytes in brain tissue at this late phase of infection. No further invasion through the BBB was seen on day 7. In conclusion, serum levels of S-100B reflect the time course of tissue injury in cerebral ischemia and cerebral infection to a similar extent. 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source MEDLINE; De Gruyter journals
subjects Adult
Aged
Aged, 80 and over
Animals
Astrocytes - metabolism
Biomarkers
Blood-Brain Barrier
Brain - pathology
Brain Ischemia - diagnosis
Candida albicans
Candida albicans - metabolism
Case-Control Studies
Female
Humans
Infection - diagnosis
Kinetics
Male
Mice
Middle Aged
Nerve Growth Factors
S100 Calcium Binding Protein beta Subunit
S100 Proteins - blood
Telencephalon - injuries
Telencephalon - microbiology
Time Factors
Tomography, X-Ray Computed
title Protein S-100B: A Serum Marker for Ischemic and Infectious Injury of Cerebral Tissue
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