Mechanism of nitrite‐stimulated catalysis by lactoperoxidase

The reactions of lactoperoxidase (LPO) intermediates compound I, compound II and compound III, with nitrite ( ) were investigated. Reduction of compound I by was rapid (k2 = 2.3 × 107 m−1·s−1; pH = 7.2) and compound II was not an intermediate, indicating that radicals are not produced when reacts wi...

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Veröffentlicht in:	European journal of biochemistry 2001-06, Vol.268 (11), p.3214-3222
Hauptverfasser:	Brück, T. B., Fielding, R. J., Symons, M. C. R., Harvey, P. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzothiazoles Catalysis - drug effects compound I compound II compound III Dose-Response Relationship, Drug Hydrogen Peroxide - chemistry Kinetics lactoperoxidase Lactoperoxidase - chemistry nitrite Nitrites - pharmacology Oxidation-Reduction Spectrophotometry Sulfonic Acids - chemistry
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