The Lack of Emx2 Causes Impairment of Reelin Signaling and Defects of Neuronal Migration in the Developing Cerebral Cortex
Neocorticogenesis in mice homozygous for an Emx2 null allele is the topic of this article. The development of both main components of neocortex, primordial plexiform layer derivatives and cortical plate, was analyzed, paying special attention to radial migration of neurons forming the cortical plate...
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| Veröffentlicht in: | The Journal of neuroscience 2000-02, Vol.20 (3), p.1109-1118 |
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| container_title | The Journal of neuroscience |
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| creator | Mallamaci, Antonello Mercurio, Sara Muzio, Luca Cecchi, Chiara Pardini, Celia Leonor Gruss, Peter Boncinelli, Edoardo |
| description | Neocorticogenesis in mice homozygous for an Emx2 null allele is the topic of this article. The development of both main components of neocortex, primordial plexiform layer derivatives and cortical plate, was analyzed, paying special attention to radial migration of neurons forming the cortical plate. The products of the Reelin gene, normally playing a key role in orchestrating radial migration of these neurons, display normal distribution at the beginning of the cortical neuronogenesis but are absent in the neocortical marginal zone of the mutant mice at the time when the cortical plate is laid down. As a consequence, the development of radial glia is impaired, and neurons making up the cortical plate display abnormal migration patterns. In addition, restricted defects along the rostrocaudal and the mediolateral axes are present in the subplate, suggesting an Emx2-specific role in priming the proper development of this layer. |
| doi_str_mv | 10.1523/JNEUROSCI.20-03-01109.2000 |
| format | Article |
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The development of both main components of neocortex, primordial plexiform layer derivatives and cortical plate, was analyzed, paying special attention to radial migration of neurons forming the cortical plate. The products of the Reelin gene, normally playing a key role in orchestrating radial migration of these neurons, display normal distribution at the beginning of the cortical neuronogenesis but are absent in the neocortical marginal zone of the mutant mice at the time when the cortical plate is laid down. As a consequence, the development of radial glia is impaired, and neurons making up the cortical plate display abnormal migration patterns. 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The development of both main components of neocortex, primordial plexiform layer derivatives and cortical plate, was analyzed, paying special attention to radial migration of neurons forming the cortical plate. The products of the Reelin gene, normally playing a key role in orchestrating radial migration of these neurons, display normal distribution at the beginning of the cortical neuronogenesis but are absent in the neocortical marginal zone of the mutant mice at the time when the cortical plate is laid down. As a consequence, the development of radial glia is impaired, and neurons making up the cortical plate display abnormal migration patterns. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Cell Adhesion Molecules, Neuronal - physiology Cell Movement - physiology Cerebral Cortex - embryology Embryo, Mammalian - cytology Embryonic and Fetal Development - physiology Emx2 protein Extracellular Matrix Proteins - physiology Female Homeodomain Proteins - genetics Homeodomain Proteins - physiology Mice Mice, Inbred Strains Mice, Knockout - genetics Mutation - physiology Nerve Tissue Proteins Neuroglia - physiology Neurons - physiology reelin Reelin Protein Serine Endopeptidases Signal Transduction - physiology Transcription Factors |
| title | The Lack of Emx2 Causes Impairment of Reelin Signaling and Defects of Neuronal Migration in the Developing Cerebral Cortex |
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