Striatal Dopamine Transporter Binding in Neuroleptic-Naive Patients With Schizophrenia Studied With Positron Emission Tomography

OBJECTIVE: Recent in vivo imaging studies indicate a dysregulated presynaptic function of the striatal dopaminergic system in patients with schizophrenia. To further explore the basis of this phenomenon, the authors studied brain dopamine transporter binding in vivo in patients with first-episode, n...

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Veröffentlicht in:	The American journal of psychiatry 2000-02, Vol.157 (2), p.269-271
Hauptverfasser:	Laakso, Aki, Vilkman, Harry, Alakare, Birgitta, Haaparanta, Merja, Bergman, Jörgen, Solin, Olof, Peurasaari, Jari, Räkköläinen, Viljo, Syvälahti, Erkka, Hietala, Jarmo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Antipsychotic Agents - therapeutic use Biological and medical sciences Brain - physiopathology Carrier Proteins - chemistry Carrier Proteins - metabolism Caudate Nucleus - chemistry Caudate Nucleus - metabolism Cocaine - analogs & derivatives Corpus Striatum - chemistry Dopamine - chemistry Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins Dopamine Uptake Inhibitors Female Functional Laterality - physiology Humans Male Medical sciences Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - metabolism Schizophrenia - physiopathology Tomography, Emission-Computed
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