Inhibitor of neurite outgrowth in humans
Axons are generally believed to be incapable of regeneration in the adult central nervous system. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin, the insulating axon sheath. These molecules incl...
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| Veröffentlicht in: | Nature (London) 2000-01, Vol.403 (6768), p.383-384 |
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| creator | PRINJHA, R MOORE, S. E VINSON, M BLAKE, S MORROW, R CHRISTIE, G MICHALOVICH, D SIMMONS, D. L WALSH, F. S |
| description | Axons are generally believed to be incapable of regeneration in the adult central nervous system. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin, the insulating axon sheath. These molecules include proteoglycans, myelin-associated glycoprotein and, in bovine brain, two proteins called Nogo. We have used this bovine sequence to identify the human Nogo gene and have isolated complementary DNA clones encoding three different Nogo isoforms that are potent inhibitors of neurine outgrowth and which may help block the regeneration of the central nervous system in adults. |
| doi_str_mv | 10.1038/35000287 |
| format | Article |
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| ispartof | Nature (London), 2000-01, Vol.403 (6768), p.383-384 |
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| subjects | Animals Biological and medical sciences Cattle Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Growth Inhibitors - genetics Growth Inhibitors - physiology Humans In Vitro Techniques Membrane Proteins - genetics Membrane Proteins - physiology Molecular Sequence Data Myelin Proteins - genetics Myelin Proteins - physiology Nerve Regeneration Neurites - physiology Nogo protein Nogo Proteins Protein Isoforms Vertebrates: nervous system and sense organs |
| title | Inhibitor of neurite outgrowth in humans |
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