Differential innervation of parvalbumin-immunoreactive interneurons of the basolateral amygdaloid complex by cortical and intrinsic inputs
In the basolateral (BL) amygdaloid complex, the excitability of projection cells is regulated by intrinsic inhibitory interneurons using γ‐aminobutyric acid (GABA) as a transmitter. A subset of these cells are labeled in a Golgi‐like manner by Parvalbumin (PV) immunohistochemistry. Recently, we have...
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| Veröffentlicht in: | Journal of comparative neurology (1911) 2000-01, Vol.416 (4), p.496-508 |
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| creator | Smith, Yoland Paré, Jean-François Paré, Denis |
| description | In the basolateral (BL) amygdaloid complex, the excitability of projection cells is regulated by intrinsic inhibitory interneurons using γ‐aminobutyric acid (GABA) as a transmitter. A subset of these cells are labeled in a Golgi‐like manner by Parvalbumin (PV) immunohistochemistry. Recently, we have shown that the overwhelming majority of axon terminals contacting these PV‐immunoreactive neurons form asymmetric synapses. The present study was undertaken to identify the source(s) of these inputs. Since previous work had revealed that thalamic axons form very few synapses on BL interneurons ( |
| doi_str_mv | 10.1002/(SICI)1096-9861(20000124)416:4<496::AID-CNE6>3.0.CO;2-N |
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A subset of these cells are labeled in a Golgi‐like manner by Parvalbumin (PV) immunohistochemistry. Recently, we have shown that the overwhelming majority of axon terminals contacting these PV‐immunoreactive neurons form asymmetric synapses. The present study was undertaken to identify the source(s) of these inputs. Since previous work had revealed that thalamic axons form very few synapses on BL interneurons (<1%), we focused on cortical and intra‐amygdaloid inputs. Iontophoretic injections of the anterograde tracers Phaseolus vulgaris‐leucoagglutinin or biotinylated dextran amine were performed in various cortical fields in cats (perirhinal, entorhinal, pre/infralimbic cortices) and monkeys (orbitofrontal region) or in the BL amygdaloid nucleus in cats. These injections resulted in a large number of anterogradely labeled terminals forming asymmetric synapses in the BL complex. Following cortical injections, numerous anterogradely labeled terminals were found in the vicinity of PV‐immunoreactive interneurons in the BL amygdala. However, only ≈1% of these terminals formed synaptic contacts with PV‐immunoreactive profiles. In contrast, as many as 11% of the terminals contributed by the intranuclear axon collaterals of BL projection cells established synapses with PV‐immunoreactive elements. Since the axon terminals of PV‐immunoreactive interneurons are enriched in GABA and they exclusively form symmetric synapses, these results suggest that PV‐immunoreactive interneurons are predominantly involved in feedback inhibition in the BL amygdaloid complex. J. Comp. Neurol. 416:496–508, 2000.</description><identifier>ISSN: 0021-9967</identifier><identifier>EISSN: 1096-9861</identifier><identifier>DOI: 10.1002/(SICI)1096-9861(20000124)416:4<496::AID-CNE6>3.0.CO;2-N</identifier><identifier>PMID: 10660880</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>amygdala ; Amygdala - cytology ; Amygdala - metabolism ; Amygdala - physiology ; Animals ; Cats - physiology ; Cerebral Cortex - physiology ; electron microscopy ; GABA ; Immunologic Techniques ; Interneurons - metabolism ; Interneurons - physiology ; local-circuit cell ; Microscopy, Electron ; Nerve Endings - physiology ; Neural Pathways - physiology ; Parvalbumins - metabolism ; Tissue Distribution ; tract-tracing</subject><ispartof>Journal of comparative neurology (1911), 2000-01, Vol.416 (4), p.496-508</ispartof><rights>Copyright © 2000 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5706-43b4c479175a523990ed0f82040105bf981c96e1f78571e21aae135879ae557d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291096-9861%2820000124%29416%3A4%3C496%3A%3AAID-CNE6%3E3.0.CO%3B2-N$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291096-9861%2820000124%29416%3A4%3C496%3A%3AAID-CNE6%3E3.0.CO%3B2-N$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10660880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Yoland</creatorcontrib><creatorcontrib>Paré, Jean-François</creatorcontrib><creatorcontrib>Paré, Denis</creatorcontrib><title>Differential innervation of parvalbumin-immunoreactive interneurons of the basolateral amygdaloid complex by cortical and intrinsic inputs</title><title>Journal of comparative neurology (1911)</title><addtitle>J. Comp. Neurol</addtitle><description>In the basolateral (BL) amygdaloid complex, the excitability of projection cells is regulated by intrinsic inhibitory interneurons using γ‐aminobutyric acid (GABA) as a transmitter. A subset of these cells are labeled in a Golgi‐like manner by Parvalbumin (PV) immunohistochemistry. Recently, we have shown that the overwhelming majority of axon terminals contacting these PV‐immunoreactive neurons form asymmetric synapses. The present study was undertaken to identify the source(s) of these inputs. Since previous work had revealed that thalamic axons form very few synapses on BL interneurons (<1%), we focused on cortical and intra‐amygdaloid inputs. Iontophoretic injections of the anterograde tracers Phaseolus vulgaris‐leucoagglutinin or biotinylated dextran amine were performed in various cortical fields in cats (perirhinal, entorhinal, pre/infralimbic cortices) and monkeys (orbitofrontal region) or in the BL amygdaloid nucleus in cats. These injections resulted in a large number of anterogradely labeled terminals forming asymmetric synapses in the BL complex. Following cortical injections, numerous anterogradely labeled terminals were found in the vicinity of PV‐immunoreactive interneurons in the BL amygdala. However, only ≈1% of these terminals formed synaptic contacts with PV‐immunoreactive profiles. In contrast, as many as 11% of the terminals contributed by the intranuclear axon collaterals of BL projection cells established synapses with PV‐immunoreactive elements. Since the axon terminals of PV‐immunoreactive interneurons are enriched in GABA and they exclusively form symmetric synapses, these results suggest that PV‐immunoreactive interneurons are predominantly involved in feedback inhibition in the BL amygdaloid complex. J. Comp. Neurol. 416:496–508, 2000.</description><subject>amygdala</subject><subject>Amygdala - cytology</subject><subject>Amygdala - metabolism</subject><subject>Amygdala - physiology</subject><subject>Animals</subject><subject>Cats - physiology</subject><subject>Cerebral Cortex - physiology</subject><subject>electron microscopy</subject><subject>GABA</subject><subject>Immunologic Techniques</subject><subject>Interneurons - metabolism</subject><subject>Interneurons - physiology</subject><subject>local-circuit cell</subject><subject>Microscopy, Electron</subject><subject>Nerve Endings - physiology</subject><subject>Neural Pathways - physiology</subject><subject>Parvalbumins - metabolism</subject><subject>Tissue Distribution</subject><subject>tract-tracing</subject><issn>0021-9967</issn><issn>1096-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdtu1DAQhiMEoqXwCihXqL3IYic-xAsCVemBhWoXqaByN3KSCbgkzmInpfsKPDUOWwoSSPWFPbZ_f2Ppi6LXlMwoIenz_fNFsTigRIlE5YLupyQMmrIDRsWcvWRKzOeHi6OkWB6LV9mMzIrVizRZ3ot2b9_cj3YDiSZKCbkTPfL-MiCUyvKH0Q4lQpA8J7vRjyPTNOjQDka3sbEW3ZUeTG_jvonXOmzacuyMTUzXjbZ3qKvBXGFIDugsjq63fooOXzAute9bHc4DSXebz7Vue1PHVd-tW7yOy00o3WCq6drWE8IZ600VqvU4-MfRg0a3Hp_crHvRx5PjD8Wb5Gx1uigOz5KKSyISlpWsYlJRyTVPM6UI1qTJU8IIJbxsVE4rJZA2MueSYkq1RprxXCqNnMs624uebblr138b0Q_QGV9h22qL_ehBklwJTuWdQSoZp4zxELzYBivXe--wgbUznXYboAQmnwCTT5jcwOQGfvuE4BPCHM4h-ITJJ2RAoFhBCstAfnrzhbHssP6LuxX4p_V30-Lmn753t_1P11_7QE62ZOMHvL4la_cVhMwkh4vlKQhy8v5d9uktnGc_Ab7PzSI</recordid><startdate>20000124</startdate><enddate>20000124</enddate><creator>Smith, Yoland</creator><creator>Paré, Jean-François</creator><creator>Paré, Denis</creator><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20000124</creationdate><title>Differential innervation of parvalbumin-immunoreactive interneurons of the basolateral amygdaloid complex by cortical and intrinsic inputs</title><author>Smith, Yoland ; Paré, Jean-François ; Paré, Denis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5706-43b4c479175a523990ed0f82040105bf981c96e1f78571e21aae135879ae557d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>amygdala</topic><topic>Amygdala - cytology</topic><topic>Amygdala - metabolism</topic><topic>Amygdala - physiology</topic><topic>Animals</topic><topic>Cats - physiology</topic><topic>Cerebral Cortex - physiology</topic><topic>electron microscopy</topic><topic>GABA</topic><topic>Immunologic Techniques</topic><topic>Interneurons - metabolism</topic><topic>Interneurons - physiology</topic><topic>local-circuit cell</topic><topic>Microscopy, Electron</topic><topic>Nerve Endings - physiology</topic><topic>Neural Pathways - physiology</topic><topic>Parvalbumins - metabolism</topic><topic>Tissue Distribution</topic><topic>tract-tracing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Yoland</creatorcontrib><creatorcontrib>Paré, Jean-François</creatorcontrib><creatorcontrib>Paré, Denis</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative neurology (1911)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Yoland</au><au>Paré, Jean-François</au><au>Paré, Denis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential innervation of parvalbumin-immunoreactive interneurons of the basolateral amygdaloid complex by cortical and intrinsic inputs</atitle><jtitle>Journal of comparative neurology (1911)</jtitle><addtitle>J. Comp. Neurol</addtitle><date>2000-01-24</date><risdate>2000</risdate><volume>416</volume><issue>4</issue><spage>496</spage><epage>508</epage><pages>496-508</pages><issn>0021-9967</issn><eissn>1096-9861</eissn><abstract>In the basolateral (BL) amygdaloid complex, the excitability of projection cells is regulated by intrinsic inhibitory interneurons using γ‐aminobutyric acid (GABA) as a transmitter. A subset of these cells are labeled in a Golgi‐like manner by Parvalbumin (PV) immunohistochemistry. Recently, we have shown that the overwhelming majority of axon terminals contacting these PV‐immunoreactive neurons form asymmetric synapses. The present study was undertaken to identify the source(s) of these inputs. Since previous work had revealed that thalamic axons form very few synapses on BL interneurons (<1%), we focused on cortical and intra‐amygdaloid inputs. Iontophoretic injections of the anterograde tracers Phaseolus vulgaris‐leucoagglutinin or biotinylated dextran amine were performed in various cortical fields in cats (perirhinal, entorhinal, pre/infralimbic cortices) and monkeys (orbitofrontal region) or in the BL amygdaloid nucleus in cats. These injections resulted in a large number of anterogradely labeled terminals forming asymmetric synapses in the BL complex. Following cortical injections, numerous anterogradely labeled terminals were found in the vicinity of PV‐immunoreactive interneurons in the BL amygdala. However, only ≈1% of these terminals formed synaptic contacts with PV‐immunoreactive profiles. In contrast, as many as 11% of the terminals contributed by the intranuclear axon collaterals of BL projection cells established synapses with PV‐immunoreactive elements. Since the axon terminals of PV‐immunoreactive interneurons are enriched in GABA and they exclusively form symmetric synapses, these results suggest that PV‐immunoreactive interneurons are predominantly involved in feedback inhibition in the BL amygdaloid complex. J. Comp. Neurol. 416:496–508, 2000.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10660880</pmid><doi>10.1002/(SICI)1096-9861(20000124)416:4<496::AID-CNE6>3.0.CO;2-N</doi><tpages>13</tpages></addata></record> |
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| subjects | amygdala Amygdala - cytology Amygdala - metabolism Amygdala - physiology Animals Cats - physiology Cerebral Cortex - physiology electron microscopy GABA Immunologic Techniques Interneurons - metabolism Interneurons - physiology local-circuit cell Microscopy, Electron Nerve Endings - physiology Neural Pathways - physiology Parvalbumins - metabolism Tissue Distribution tract-tracing |
| title | Differential innervation of parvalbumin-immunoreactive interneurons of the basolateral amygdaloid complex by cortical and intrinsic inputs |
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