Dietary fat intake and risk of type 2 diabetes in women
The long-term relations between specific types of dietary fat and risk of type 2 diabetes remain unclear. Our objective was to examine the relations between dietary fat intakes and the risk of type 2 diabetes. We prospectively followed 84204 women aged 34-59 y with no diabetes, cardiovascular diseas...
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Veröffentlicht in: | The American journal of clinical nutrition 2001-06, Vol.73 (6), p.1019-1026 |
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creator | SALMERON, Jorge HU, Frank B MANSON, Joann E STAMPFER, Meir J COLDITZ, Graham A RIMM, Eric B WILLETT, Walter C |
description | The long-term relations between specific types of dietary fat and risk of type 2 diabetes remain unclear.
Our objective was to examine the relations between dietary fat intakes and the risk of type 2 diabetes.
We prospectively followed 84204 women aged 34-59 y with no diabetes, cardiovascular disease, or cancer in 1980. Detailed dietary information was assessed at baseline and updated in 1984, 1986, and 1990 by using validated questionnaires. Relative risks of type 2 diabetes were obtained from pooled logistic models adjusted for nondietary and dietary covariates.
During 14 y of follow-up, 2507 incident cases of type 2 diabetes were documented. Total fat intake, compared with equivalent energy intake from carbohydrates, was not associated with risk of type 2 diabetes; for a 5% increase in total energy from fat, the relative risk (RR) was 0.98 (95% CI: 0.94, 1.02). Intakes of saturated or monounsaturated fatty acids were also not significantly associated with the risk of diabetes. However, for a 5% increase in energy from polyunsaturated fat, the RR was 0.63 (0.53, 0.76; P < 0.0001) and for a 2% increase in energy from trans fatty acids the RR was 1.39 (1.15, 1.67; P = 0.0006). We estimated that replacing 2% of energy from trans fatty acids isoenergetically with polyunsaturated fat would lead to a 40% lower risk (RR: 0.60; 95% CI: 0.48, 0.75).
These data suggest that total fat and saturated and monounsaturated fatty acid intakes are not associated with risk of type 2 diabetes in women, but that trans fatty acids increase and polyunsaturated fatty acids reduce risk. Substituting nonhydrogenated polyunsaturated fatty acids for trans fatty acids would likely reduce the risk of type 2 diabetes substantially. |
doi_str_mv | 10.1093/ajcn/73.6.1019 |
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Our objective was to examine the relations between dietary fat intakes and the risk of type 2 diabetes.
We prospectively followed 84204 women aged 34-59 y with no diabetes, cardiovascular disease, or cancer in 1980. Detailed dietary information was assessed at baseline and updated in 1984, 1986, and 1990 by using validated questionnaires. Relative risks of type 2 diabetes were obtained from pooled logistic models adjusted for nondietary and dietary covariates.
During 14 y of follow-up, 2507 incident cases of type 2 diabetes were documented. Total fat intake, compared with equivalent energy intake from carbohydrates, was not associated with risk of type 2 diabetes; for a 5% increase in total energy from fat, the relative risk (RR) was 0.98 (95% CI: 0.94, 1.02). Intakes of saturated or monounsaturated fatty acids were also not significantly associated with the risk of diabetes. However, for a 5% increase in energy from polyunsaturated fat, the RR was 0.63 (0.53, 0.76; P < 0.0001) and for a 2% increase in energy from trans fatty acids the RR was 1.39 (1.15, 1.67; P = 0.0006). We estimated that replacing 2% of energy from trans fatty acids isoenergetically with polyunsaturated fat would lead to a 40% lower risk (RR: 0.60; 95% CI: 0.48, 0.75).
These data suggest that total fat and saturated and monounsaturated fatty acid intakes are not associated with risk of type 2 diabetes in women, but that trans fatty acids increase and polyunsaturated fatty acids reduce risk. Substituting nonhydrogenated polyunsaturated fatty acids for trans fatty acids would likely reduce the risk of type 2 diabetes substantially.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/73.6.1019</identifier><identifier>PMID: 11382654</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Clinical Nutrition</publisher><subject>Adult ; Biological and medical sciences ; Body Mass Index ; Cholesterol - blood ; Diabetes ; Diabetes Mellitus, Type 2 - etiology ; Diabetes. Impaired glucose tolerance ; Diet ; Diet Surveys ; Dietary Fats - administration & dosage ; Dietary Fats - adverse effects ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty acids ; Fatty Acids - administration & dosage ; Fatty Acids - adverse effects ; Female ; Health risk assessment ; Humans ; Medical sciences ; Middle Aged ; Oils & fats ; Prospective Studies ; Risk ; Stereoisomerism ; Surveys and Questionnaires ; Women</subject><ispartof>The American journal of clinical nutrition, 2001-06, Vol.73 (6), p.1019-1026</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Jun 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-803d185281ac6ae3b597bb3e23b139f6918032bac06865789b61a232c9ad49253</citedby><cites>FETCH-LOGICAL-c387t-803d185281ac6ae3b597bb3e23b139f6918032bac06865789b61a232c9ad49253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23910,23911,25119,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1023278$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11382654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SALMERON, Jorge</creatorcontrib><creatorcontrib>HU, Frank B</creatorcontrib><creatorcontrib>MANSON, Joann E</creatorcontrib><creatorcontrib>STAMPFER, Meir J</creatorcontrib><creatorcontrib>COLDITZ, Graham A</creatorcontrib><creatorcontrib>RIMM, Eric B</creatorcontrib><creatorcontrib>WILLETT, Walter C</creatorcontrib><title>Dietary fat intake and risk of type 2 diabetes in women</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>The long-term relations between specific types of dietary fat and risk of type 2 diabetes remain unclear.
Our objective was to examine the relations between dietary fat intakes and the risk of type 2 diabetes.
We prospectively followed 84204 women aged 34-59 y with no diabetes, cardiovascular disease, or cancer in 1980. Detailed dietary information was assessed at baseline and updated in 1984, 1986, and 1990 by using validated questionnaires. Relative risks of type 2 diabetes were obtained from pooled logistic models adjusted for nondietary and dietary covariates.
During 14 y of follow-up, 2507 incident cases of type 2 diabetes were documented. Total fat intake, compared with equivalent energy intake from carbohydrates, was not associated with risk of type 2 diabetes; for a 5% increase in total energy from fat, the relative risk (RR) was 0.98 (95% CI: 0.94, 1.02). Intakes of saturated or monounsaturated fatty acids were also not significantly associated with the risk of diabetes. However, for a 5% increase in energy from polyunsaturated fat, the RR was 0.63 (0.53, 0.76; P < 0.0001) and for a 2% increase in energy from trans fatty acids the RR was 1.39 (1.15, 1.67; P = 0.0006). We estimated that replacing 2% of energy from trans fatty acids isoenergetically with polyunsaturated fat would lead to a 40% lower risk (RR: 0.60; 95% CI: 0.48, 0.75).
These data suggest that total fat and saturated and monounsaturated fatty acid intakes are not associated with risk of type 2 diabetes in women, but that trans fatty acids increase and polyunsaturated fatty acids reduce risk. Substituting nonhydrogenated polyunsaturated fatty acids for trans fatty acids would likely reduce the risk of type 2 diabetes substantially.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cholesterol - blood</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diet</subject><subject>Diet Surveys</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - adverse effects</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fatty acids</subject><subject>Fatty Acids - administration & dosage</subject><subject>Fatty Acids - adverse effects</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oils & fats</subject><subject>Prospective Studies</subject><subject>Risk</subject><subject>Stereoisomerism</subject><subject>Surveys and Questionnaires</subject><subject>Women</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0EtLAzEUBeAgiq3VrUsJIu6mTXI7eSylPqHgRtchyWRg2nnUZAbpvzelA4qrS-DL4d6D0DUlc0oULMzGtQsBc56eVJ2gKVUgM2BEnKIpIYRlivJ8gi5i3BBC2VLyczShFCTj-XKKxGPlexP2uDQ9rtrebD02bYFDFbe4K3G_33nMcFEZ63sfE8HfXePbS3RWmjr6q3HO0Ofz08fqNVu_v7ytHtaZAyn6TBIoqMyZpMZx48HmSlgLnoGloEquaBLMGke45LmQynJqGDCnTLFULIcZuj_m7kL3NfjY66aKzte1aX03RC2IVJwKnuDtP7jphtCm3TQDqhiQXCU0PyIXuhiDL_UuVE06X1OiD33qQ59agOb60Gf6cDOmDrbxxS8fC0zgbgQmOlOXwbSuin9i0zFCwg9gcXpt</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>SALMERON, Jorge</creator><creator>HU, Frank B</creator><creator>MANSON, Joann E</creator><creator>STAMPFER, Meir J</creator><creator>COLDITZ, Graham A</creator><creator>RIMM, Eric B</creator><creator>WILLETT, Walter C</creator><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Dietary fat intake and risk of type 2 diabetes in women</title><author>SALMERON, Jorge ; HU, Frank B ; MANSON, Joann E ; STAMPFER, Meir J ; COLDITZ, Graham A ; RIMM, Eric B ; WILLETT, Walter C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-803d185281ac6ae3b597bb3e23b139f6918032bac06865789b61a232c9ad49253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cholesterol - blood</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diet</topic><topic>Diet Surveys</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - adverse effects</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fatty acids</topic><topic>Fatty Acids - administration & dosage</topic><topic>Fatty Acids - adverse effects</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oils & fats</topic><topic>Prospective Studies</topic><topic>Risk</topic><topic>Stereoisomerism</topic><topic>Surveys and Questionnaires</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SALMERON, Jorge</creatorcontrib><creatorcontrib>HU, Frank B</creatorcontrib><creatorcontrib>MANSON, Joann E</creatorcontrib><creatorcontrib>STAMPFER, Meir J</creatorcontrib><creatorcontrib>COLDITZ, Graham A</creatorcontrib><creatorcontrib>RIMM, Eric B</creatorcontrib><creatorcontrib>WILLETT, Walter C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SALMERON, Jorge</au><au>HU, Frank B</au><au>MANSON, Joann E</au><au>STAMPFER, Meir J</au><au>COLDITZ, Graham A</au><au>RIMM, Eric B</au><au>WILLETT, Walter C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary fat intake and risk of type 2 diabetes in women</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>73</volume><issue>6</issue><spage>1019</spage><spage>1001</spage><epage>1026</epage><epage>1002</epage><pages>1019-1026</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>The long-term relations between specific types of dietary fat and risk of type 2 diabetes remain unclear.
Our objective was to examine the relations between dietary fat intakes and the risk of type 2 diabetes.
We prospectively followed 84204 women aged 34-59 y with no diabetes, cardiovascular disease, or cancer in 1980. Detailed dietary information was assessed at baseline and updated in 1984, 1986, and 1990 by using validated questionnaires. Relative risks of type 2 diabetes were obtained from pooled logistic models adjusted for nondietary and dietary covariates.
During 14 y of follow-up, 2507 incident cases of type 2 diabetes were documented. Total fat intake, compared with equivalent energy intake from carbohydrates, was not associated with risk of type 2 diabetes; for a 5% increase in total energy from fat, the relative risk (RR) was 0.98 (95% CI: 0.94, 1.02). Intakes of saturated or monounsaturated fatty acids were also not significantly associated with the risk of diabetes. However, for a 5% increase in energy from polyunsaturated fat, the RR was 0.63 (0.53, 0.76; P < 0.0001) and for a 2% increase in energy from trans fatty acids the RR was 1.39 (1.15, 1.67; P = 0.0006). We estimated that replacing 2% of energy from trans fatty acids isoenergetically with polyunsaturated fat would lead to a 40% lower risk (RR: 0.60; 95% CI: 0.48, 0.75).
These data suggest that total fat and saturated and monounsaturated fatty acid intakes are not associated with risk of type 2 diabetes in women, but that trans fatty acids increase and polyunsaturated fatty acids reduce risk. Substituting nonhydrogenated polyunsaturated fatty acids for trans fatty acids would likely reduce the risk of type 2 diabetes substantially.</abstract><cop>Bethesda, MD</cop><pub>American Society for Clinical Nutrition</pub><pmid>11382654</pmid><doi>10.1093/ajcn/73.6.1019</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Biological and medical sciences Body Mass Index Cholesterol - blood Diabetes Diabetes Mellitus, Type 2 - etiology Diabetes. Impaired glucose tolerance Diet Diet Surveys Dietary Fats - administration & dosage Dietary Fats - adverse effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Fatty Acids - administration & dosage Fatty Acids - adverse effects Female Health risk assessment Humans Medical sciences Middle Aged Oils & fats Prospective Studies Risk Stereoisomerism Surveys and Questionnaires Women |
title | Dietary fat intake and risk of type 2 diabetes in women |
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