Dietary fat intake and risk of type 2 diabetes in women

The long-term relations between specific types of dietary fat and risk of type 2 diabetes remain unclear. Our objective was to examine the relations between dietary fat intakes and the risk of type 2 diabetes. We prospectively followed 84204 women aged 34-59 y with no diabetes, cardiovascular diseas...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The American journal of clinical nutrition 2001-06, Vol.73 (6), p.1019-1026
Hauptverfasser: SALMERON, Jorge, HU, Frank B, MANSON, Joann E, STAMPFER, Meir J, COLDITZ, Graham A, RIMM, Eric B, WILLETT, Walter C
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1026
container_issue 6
container_start_page 1019
container_title The American journal of clinical nutrition
container_volume 73
creator SALMERON, Jorge
HU, Frank B
MANSON, Joann E
STAMPFER, Meir J
COLDITZ, Graham A
RIMM, Eric B
WILLETT, Walter C
description The long-term relations between specific types of dietary fat and risk of type 2 diabetes remain unclear. Our objective was to examine the relations between dietary fat intakes and the risk of type 2 diabetes. We prospectively followed 84204 women aged 34-59 y with no diabetes, cardiovascular disease, or cancer in 1980. Detailed dietary information was assessed at baseline and updated in 1984, 1986, and 1990 by using validated questionnaires. Relative risks of type 2 diabetes were obtained from pooled logistic models adjusted for nondietary and dietary covariates. During 14 y of follow-up, 2507 incident cases of type 2 diabetes were documented. Total fat intake, compared with equivalent energy intake from carbohydrates, was not associated with risk of type 2 diabetes; for a 5% increase in total energy from fat, the relative risk (RR) was 0.98 (95% CI: 0.94, 1.02). Intakes of saturated or monounsaturated fatty acids were also not significantly associated with the risk of diabetes. However, for a 5% increase in energy from polyunsaturated fat, the RR was 0.63 (0.53, 0.76; P < 0.0001) and for a 2% increase in energy from trans fatty acids the RR was 1.39 (1.15, 1.67; P = 0.0006). We estimated that replacing 2% of energy from trans fatty acids isoenergetically with polyunsaturated fat would lead to a 40% lower risk (RR: 0.60; 95% CI: 0.48, 0.75). These data suggest that total fat and saturated and monounsaturated fatty acid intakes are not associated with risk of type 2 diabetes in women, but that trans fatty acids increase and polyunsaturated fatty acids reduce risk. Substituting nonhydrogenated polyunsaturated fatty acids for trans fatty acids would likely reduce the risk of type 2 diabetes substantially.
doi_str_mv 10.1093/ajcn/73.6.1019
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70896176</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70896176</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-803d185281ac6ae3b597bb3e23b139f6918032bac06865789b61a232c9ad49253</originalsourceid><addsrcrecordid>eNpd0EtLAzEUBeAgiq3VrUsJIu6mTXI7eSylPqHgRtchyWRg2nnUZAbpvzelA4qrS-DL4d6D0DUlc0oULMzGtQsBc56eVJ2gKVUgM2BEnKIpIYRlivJ8gi5i3BBC2VLyczShFCTj-XKKxGPlexP2uDQ9rtrebD02bYFDFbe4K3G_33nMcFEZ63sfE8HfXePbS3RWmjr6q3HO0Ofz08fqNVu_v7ytHtaZAyn6TBIoqMyZpMZx48HmSlgLnoGloEquaBLMGke45LmQynJqGDCnTLFULIcZuj_m7kL3NfjY66aKzte1aX03RC2IVJwKnuDtP7jphtCm3TQDqhiQXCU0PyIXuhiDL_UuVE06X1OiD33qQ59agOb60Gf6cDOmDrbxxS8fC0zgbgQmOlOXwbSuin9i0zFCwg9gcXpt</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>231923059</pqid></control><display><type>article</type><title>Dietary fat intake and risk of type 2 diabetes in women</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>SALMERON, Jorge ; HU, Frank B ; MANSON, Joann E ; STAMPFER, Meir J ; COLDITZ, Graham A ; RIMM, Eric B ; WILLETT, Walter C</creator><creatorcontrib>SALMERON, Jorge ; HU, Frank B ; MANSON, Joann E ; STAMPFER, Meir J ; COLDITZ, Graham A ; RIMM, Eric B ; WILLETT, Walter C</creatorcontrib><description>The long-term relations between specific types of dietary fat and risk of type 2 diabetes remain unclear. Our objective was to examine the relations between dietary fat intakes and the risk of type 2 diabetes. We prospectively followed 84204 women aged 34-59 y with no diabetes, cardiovascular disease, or cancer in 1980. Detailed dietary information was assessed at baseline and updated in 1984, 1986, and 1990 by using validated questionnaires. Relative risks of type 2 diabetes were obtained from pooled logistic models adjusted for nondietary and dietary covariates. During 14 y of follow-up, 2507 incident cases of type 2 diabetes were documented. Total fat intake, compared with equivalent energy intake from carbohydrates, was not associated with risk of type 2 diabetes; for a 5% increase in total energy from fat, the relative risk (RR) was 0.98 (95% CI: 0.94, 1.02). Intakes of saturated or monounsaturated fatty acids were also not significantly associated with the risk of diabetes. However, for a 5% increase in energy from polyunsaturated fat, the RR was 0.63 (0.53, 0.76; P &lt; 0.0001) and for a 2% increase in energy from trans fatty acids the RR was 1.39 (1.15, 1.67; P = 0.0006). We estimated that replacing 2% of energy from trans fatty acids isoenergetically with polyunsaturated fat would lead to a 40% lower risk (RR: 0.60; 95% CI: 0.48, 0.75). These data suggest that total fat and saturated and monounsaturated fatty acid intakes are not associated with risk of type 2 diabetes in women, but that trans fatty acids increase and polyunsaturated fatty acids reduce risk. Substituting nonhydrogenated polyunsaturated fatty acids for trans fatty acids would likely reduce the risk of type 2 diabetes substantially.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/73.6.1019</identifier><identifier>PMID: 11382654</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Clinical Nutrition</publisher><subject>Adult ; Biological and medical sciences ; Body Mass Index ; Cholesterol - blood ; Diabetes ; Diabetes Mellitus, Type 2 - etiology ; Diabetes. Impaired glucose tolerance ; Diet ; Diet Surveys ; Dietary Fats - administration &amp; dosage ; Dietary Fats - adverse effects ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty acids ; Fatty Acids - administration &amp; dosage ; Fatty Acids - adverse effects ; Female ; Health risk assessment ; Humans ; Medical sciences ; Middle Aged ; Oils &amp; fats ; Prospective Studies ; Risk ; Stereoisomerism ; Surveys and Questionnaires ; Women</subject><ispartof>The American journal of clinical nutrition, 2001-06, Vol.73 (6), p.1019-1026</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Jun 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-803d185281ac6ae3b597bb3e23b139f6918032bac06865789b61a232c9ad49253</citedby><cites>FETCH-LOGICAL-c387t-803d185281ac6ae3b597bb3e23b139f6918032bac06865789b61a232c9ad49253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23910,23911,25119,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1023278$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11382654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SALMERON, Jorge</creatorcontrib><creatorcontrib>HU, Frank B</creatorcontrib><creatorcontrib>MANSON, Joann E</creatorcontrib><creatorcontrib>STAMPFER, Meir J</creatorcontrib><creatorcontrib>COLDITZ, Graham A</creatorcontrib><creatorcontrib>RIMM, Eric B</creatorcontrib><creatorcontrib>WILLETT, Walter C</creatorcontrib><title>Dietary fat intake and risk of type 2 diabetes in women</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>The long-term relations between specific types of dietary fat and risk of type 2 diabetes remain unclear. Our objective was to examine the relations between dietary fat intakes and the risk of type 2 diabetes. We prospectively followed 84204 women aged 34-59 y with no diabetes, cardiovascular disease, or cancer in 1980. Detailed dietary information was assessed at baseline and updated in 1984, 1986, and 1990 by using validated questionnaires. Relative risks of type 2 diabetes were obtained from pooled logistic models adjusted for nondietary and dietary covariates. During 14 y of follow-up, 2507 incident cases of type 2 diabetes were documented. Total fat intake, compared with equivalent energy intake from carbohydrates, was not associated with risk of type 2 diabetes; for a 5% increase in total energy from fat, the relative risk (RR) was 0.98 (95% CI: 0.94, 1.02). Intakes of saturated or monounsaturated fatty acids were also not significantly associated with the risk of diabetes. However, for a 5% increase in energy from polyunsaturated fat, the RR was 0.63 (0.53, 0.76; P &lt; 0.0001) and for a 2% increase in energy from trans fatty acids the RR was 1.39 (1.15, 1.67; P = 0.0006). We estimated that replacing 2% of energy from trans fatty acids isoenergetically with polyunsaturated fat would lead to a 40% lower risk (RR: 0.60; 95% CI: 0.48, 0.75). These data suggest that total fat and saturated and monounsaturated fatty acid intakes are not associated with risk of type 2 diabetes in women, but that trans fatty acids increase and polyunsaturated fatty acids reduce risk. Substituting nonhydrogenated polyunsaturated fatty acids for trans fatty acids would likely reduce the risk of type 2 diabetes substantially.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cholesterol - blood</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diet</subject><subject>Diet Surveys</subject><subject>Dietary Fats - administration &amp; dosage</subject><subject>Dietary Fats - adverse effects</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fatty acids</subject><subject>Fatty Acids - administration &amp; dosage</subject><subject>Fatty Acids - adverse effects</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oils &amp; fats</subject><subject>Prospective Studies</subject><subject>Risk</subject><subject>Stereoisomerism</subject><subject>Surveys and Questionnaires</subject><subject>Women</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0EtLAzEUBeAgiq3VrUsJIu6mTXI7eSylPqHgRtchyWRg2nnUZAbpvzelA4qrS-DL4d6D0DUlc0oULMzGtQsBc56eVJ2gKVUgM2BEnKIpIYRlivJ8gi5i3BBC2VLyczShFCTj-XKKxGPlexP2uDQ9rtrebD02bYFDFbe4K3G_33nMcFEZ63sfE8HfXePbS3RWmjr6q3HO0Ofz08fqNVu_v7ytHtaZAyn6TBIoqMyZpMZx48HmSlgLnoGloEquaBLMGke45LmQynJqGDCnTLFULIcZuj_m7kL3NfjY66aKzte1aX03RC2IVJwKnuDtP7jphtCm3TQDqhiQXCU0PyIXuhiDL_UuVE06X1OiD33qQ59agOb60Gf6cDOmDrbxxS8fC0zgbgQmOlOXwbSuin9i0zFCwg9gcXpt</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>SALMERON, Jorge</creator><creator>HU, Frank B</creator><creator>MANSON, Joann E</creator><creator>STAMPFER, Meir J</creator><creator>COLDITZ, Graham A</creator><creator>RIMM, Eric B</creator><creator>WILLETT, Walter C</creator><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Dietary fat intake and risk of type 2 diabetes in women</title><author>SALMERON, Jorge ; HU, Frank B ; MANSON, Joann E ; STAMPFER, Meir J ; COLDITZ, Graham A ; RIMM, Eric B ; WILLETT, Walter C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-803d185281ac6ae3b597bb3e23b139f6918032bac06865789b61a232c9ad49253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cholesterol - blood</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diet</topic><topic>Diet Surveys</topic><topic>Dietary Fats - administration &amp; dosage</topic><topic>Dietary Fats - adverse effects</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fatty acids</topic><topic>Fatty Acids - administration &amp; dosage</topic><topic>Fatty Acids - adverse effects</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oils &amp; fats</topic><topic>Prospective Studies</topic><topic>Risk</topic><topic>Stereoisomerism</topic><topic>Surveys and Questionnaires</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SALMERON, Jorge</creatorcontrib><creatorcontrib>HU, Frank B</creatorcontrib><creatorcontrib>MANSON, Joann E</creatorcontrib><creatorcontrib>STAMPFER, Meir J</creatorcontrib><creatorcontrib>COLDITZ, Graham A</creatorcontrib><creatorcontrib>RIMM, Eric B</creatorcontrib><creatorcontrib>WILLETT, Walter C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SALMERON, Jorge</au><au>HU, Frank B</au><au>MANSON, Joann E</au><au>STAMPFER, Meir J</au><au>COLDITZ, Graham A</au><au>RIMM, Eric B</au><au>WILLETT, Walter C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary fat intake and risk of type 2 diabetes in women</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>73</volume><issue>6</issue><spage>1019</spage><spage>1001</spage><epage>1026</epage><epage>1002</epage><pages>1019-1026</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>The long-term relations between specific types of dietary fat and risk of type 2 diabetes remain unclear. Our objective was to examine the relations between dietary fat intakes and the risk of type 2 diabetes. We prospectively followed 84204 women aged 34-59 y with no diabetes, cardiovascular disease, or cancer in 1980. Detailed dietary information was assessed at baseline and updated in 1984, 1986, and 1990 by using validated questionnaires. Relative risks of type 2 diabetes were obtained from pooled logistic models adjusted for nondietary and dietary covariates. During 14 y of follow-up, 2507 incident cases of type 2 diabetes were documented. Total fat intake, compared with equivalent energy intake from carbohydrates, was not associated with risk of type 2 diabetes; for a 5% increase in total energy from fat, the relative risk (RR) was 0.98 (95% CI: 0.94, 1.02). Intakes of saturated or monounsaturated fatty acids were also not significantly associated with the risk of diabetes. However, for a 5% increase in energy from polyunsaturated fat, the RR was 0.63 (0.53, 0.76; P &lt; 0.0001) and for a 2% increase in energy from trans fatty acids the RR was 1.39 (1.15, 1.67; P = 0.0006). We estimated that replacing 2% of energy from trans fatty acids isoenergetically with polyunsaturated fat would lead to a 40% lower risk (RR: 0.60; 95% CI: 0.48, 0.75). These data suggest that total fat and saturated and monounsaturated fatty acid intakes are not associated with risk of type 2 diabetes in women, but that trans fatty acids increase and polyunsaturated fatty acids reduce risk. Substituting nonhydrogenated polyunsaturated fatty acids for trans fatty acids would likely reduce the risk of type 2 diabetes substantially.</abstract><cop>Bethesda, MD</cop><pub>American Society for Clinical Nutrition</pub><pmid>11382654</pmid><doi>10.1093/ajcn/73.6.1019</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0002-9165
ispartof The American journal of clinical nutrition, 2001-06, Vol.73 (6), p.1019-1026
issn 0002-9165
1938-3207
language eng
recordid cdi_proquest_miscellaneous_70896176
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Adult
Biological and medical sciences
Body Mass Index
Cholesterol - blood
Diabetes
Diabetes Mellitus, Type 2 - etiology
Diabetes. Impaired glucose tolerance
Diet
Diet Surveys
Dietary Fats - administration & dosage
Dietary Fats - adverse effects
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty acids
Fatty Acids - administration & dosage
Fatty Acids - adverse effects
Female
Health risk assessment
Humans
Medical sciences
Middle Aged
Oils & fats
Prospective Studies
Risk
Stereoisomerism
Surveys and Questionnaires
Women
title Dietary fat intake and risk of type 2 diabetes in women
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T01%3A46%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dietary%20fat%20intake%20and%20risk%20of%20type%202%20diabetes%20in%20women&rft.jtitle=The%20American%20journal%20of%20clinical%20nutrition&rft.au=SALMERON,%20Jorge&rft.date=2001-06-01&rft.volume=73&rft.issue=6&rft.spage=1019&rft.epage=1026&rft.pages=1019-1026&rft.issn=0002-9165&rft.eissn=1938-3207&rft.coden=AJCNAC&rft_id=info:doi/10.1093/ajcn/73.6.1019&rft_dat=%3Cproquest_cross%3E70896176%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=231923059&rft_id=info:pmid/11382654&rfr_iscdi=true