Blockade of muscarinic, rather than nicotinic, receptors impairs attention, but does not interact with serotonin depletion

The cholinergic system is considered to be essential for attention and the degeneration of the cholinergic system in Alzheimer's disease (AD) correlates with the cognitive decline seen in AD patients. The serotonergic system also degenerates in AD, but its role in the modulation of cognitive fu...

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Veröffentlicht in:	Psychopharmacologia 2000-02, Vol.148 (2), p.111-123
Hauptverfasser:	RUOTSALAINEN, S, MIETTINEN, R, MACDONALD, E, KOIVISTO, E, SIRVIÖ, J
Format:	Artikel
Sprache:	eng
Schlagworte:	5,7-Dihydroxytryptamine - administration & dosage Accuracy Acetylcholine receptors Acetylcholine receptors (muscarinic) Acetylcholine receptors (nicotinic) Activity levels. Psychomotricity Alzheimer's disease Animals Attention - drug effects Attention - physiology Behavior, Animal - drug effects Biological and medical sciences Brain - drug effects Brain - metabolism Cholinergic Antagonists - pharmacology Cholinergic transmission Cognition - drug effects Cognitive ability Cortex (frontal) Fundamental and applied biological sciences. Psychology Hippocampus Hydroxyindoleacetic Acid - metabolism Impulsive behavior Impulsivity Injections, Intraventricular Lesions Male Mecamylamine Motor activity Muscarinic Antagonists - pharmacology Neostriatum Nerve Fibers - drug effects Nerve Fibers - physiology Neurodegenerative diseases Neurons - drug effects Nicotinic Antagonists - pharmacology p-Chloroamphetamine p-Chloroamphetamine - pharmacology Photic Stimulation Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Reaction Time - drug effects Reaction time task Receptors, Cholinergic - drug effects Receptors, Cholinergic - metabolism Receptors, Muscarinic - drug effects Receptors, Muscarinic - metabolism Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism Scopolamine Serotonin - metabolism Serotonin Agents - administration & dosage Serotonin receptors Task Performance and Analysis Vigilance. Attention. Sleep
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