Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats
The aim of the present study was to investigate the maternal-fetal transport, incorporation, and effects on liver delta-6 fatty-acid desaturase activity of dietary trans fatty acids in pregnant rats. Three groups of six rats each were fed three experimental diets containing approximately 0%, 15%, an...
Gespeichert in:
| Veröffentlicht in: | Pediatric research 2000-02, Vol.47 (2), p.278-283 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 283 |
|---|---|
| container_issue | 2 |
| container_start_page | 278 |
| container_title | Pediatric research |
| container_volume | 47 |
| creator | LARQUE, E PEREZ-LLAMAS, F PUERTA, V GIRON, M. D SUAREZ, M. D ZAMORA, S GIL, A |
| description | The aim of the present study was to investigate the maternal-fetal transport, incorporation, and effects on liver delta-6 fatty-acid desaturase activity of dietary trans fatty acids in pregnant rats. Three groups of six rats each were fed three experimental diets containing approximately 0%, 15%, and 30% of trans fatty acids but containing the same proportion of linoleic (18:2 n-6) and a-linolenic (18:3 n-3) acids for 10 wk. On d 20 of pregnancy, the animals from each group were killed. We determined the fatty acid profiles in plasma, brain, and liver microsomes of pregnant rats, as well as in placenta and fetal liver and brain. No changes were found in the number of fetuses of the pregnant rats. Trans fatty acids were incorporated in high concentrations in placenta and in maternal and fetal tissues, except brain, strongly elevating the linoleic acid proportion and lowering that of docosahexaenoic acid. The delta-6 fatty-acid desaturase activity in the liver microsomes of the pregnant rats was inhibited by trans isomers. In conclusion, high intakes of trans fatty acids partially inhibit liver delta-6 fatty-acid desaturase in pregnant rats, which may explain, in part, the low concentrations of docosahexaenoic acid in pregnant and fetal tissues. However, the fatty acid composition of both fetal and pregnant rat brain remains mostly unaffected regardless of the dietary trans fatty acid content. |
| doi_str_mv | 10.1203/00006450-200002000-00021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70894692</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70894692</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-285cbcd24d4ac4dc7fa7268055ac11c41435ee44dd63c0fa4d94f1bfc310aa5b3</originalsourceid><addsrcrecordid>eNpNkctuHCEQRVHkKB7b-QWLReRdO0VDv5aR45dkKZt43aouIMbqgTEwkWeZPzfziBMWFIhzKXFgjAu4FDXIr1BGqxqo6u1qO1XbKj6whWhk2SjVHbEFgBSVHIb-mJ2k9AwgVNOrT-xYQNsp2QwL9ue7MxnjhueIPnGLOW84ktOJo7WGMteBQsIn84rGB0e7Q07Bk_Elk10oMef5asa0RI5e89n9NpFP68x9yHyKWI6D5atofnn0ecfY0nXmJZ_O2EeLczKfD_WUPd5c_7y6qx5-3N5ffXuoSA6Qq7pvaCJdK62QlKbOYle3PTQNkhCkRHmPMUpp3UoCi0oPyorJkhSA2EzylF3s713F8LI2KY9Ll8jMM3oT1mnsoB9UO9QF7PcgxZBSNHZcRbcsjkYB41b_-Ff_-K5_3Okv0fNDj_W0NPq_4N53Ab4cAEyEsy3SyaV_nAQoXyTfAJXajzI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70894692</pqid></control><display><type>article</type><title>Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>LARQUE, E ; PEREZ-LLAMAS, F ; PUERTA, V ; GIRON, M. D ; SUAREZ, M. D ; ZAMORA, S ; GIL, A</creator><creatorcontrib>LARQUE, E ; PEREZ-LLAMAS, F ; PUERTA, V ; GIRON, M. D ; SUAREZ, M. D ; ZAMORA, S ; GIL, A</creatorcontrib><description>The aim of the present study was to investigate the maternal-fetal transport, incorporation, and effects on liver delta-6 fatty-acid desaturase activity of dietary trans fatty acids in pregnant rats. Three groups of six rats each were fed three experimental diets containing approximately 0%, 15%, and 30% of trans fatty acids but containing the same proportion of linoleic (18:2 n-6) and a-linolenic (18:3 n-3) acids for 10 wk. On d 20 of pregnancy, the animals from each group were killed. We determined the fatty acid profiles in plasma, brain, and liver microsomes of pregnant rats, as well as in placenta and fetal liver and brain. No changes were found in the number of fetuses of the pregnant rats. Trans fatty acids were incorporated in high concentrations in placenta and in maternal and fetal tissues, except brain, strongly elevating the linoleic acid proportion and lowering that of docosahexaenoic acid. The delta-6 fatty-acid desaturase activity in the liver microsomes of the pregnant rats was inhibited by trans isomers. In conclusion, high intakes of trans fatty acids partially inhibit liver delta-6 fatty-acid desaturase in pregnant rats, which may explain, in part, the low concentrations of docosahexaenoic acid in pregnant and fetal tissues. However, the fatty acid composition of both fetal and pregnant rat brain remains mostly unaffected regardless of the dietary trans fatty acid content.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/00006450-200002000-00021</identifier><identifier>PMID: 10674359</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>alpha-Linolenic Acid - pharmacology ; Animals ; Biological and medical sciences ; Brain - metabolism ; Dietary Fats - pharmacology ; Docosahexaenoic Acids - blood ; Docosahexaenoic Acids - metabolism ; Fatty Acids - administration & dosage ; Fatty Acids - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Linoleic Acid - pharmacology ; Liver - metabolism ; Mother. Fetoplacental unit. Mammary gland. Milk ; Pregnancy ; Pregnancy. Parturition. Lactation ; Rats ; Rats, Wistar ; Vertebrates: reproduction</subject><ispartof>Pediatric research, 2000-02, Vol.47 (2), p.278-283</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-285cbcd24d4ac4dc7fa7268055ac11c41435ee44dd63c0fa4d94f1bfc310aa5b3</citedby><cites>FETCH-LOGICAL-c390t-285cbcd24d4ac4dc7fa7268055ac11c41435ee44dd63c0fa4d94f1bfc310aa5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1300458$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10674359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LARQUE, E</creatorcontrib><creatorcontrib>PEREZ-LLAMAS, F</creatorcontrib><creatorcontrib>PUERTA, V</creatorcontrib><creatorcontrib>GIRON, M. D</creatorcontrib><creatorcontrib>SUAREZ, M. D</creatorcontrib><creatorcontrib>ZAMORA, S</creatorcontrib><creatorcontrib>GIL, A</creatorcontrib><title>Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><description>The aim of the present study was to investigate the maternal-fetal transport, incorporation, and effects on liver delta-6 fatty-acid desaturase activity of dietary trans fatty acids in pregnant rats. Three groups of six rats each were fed three experimental diets containing approximately 0%, 15%, and 30% of trans fatty acids but containing the same proportion of linoleic (18:2 n-6) and a-linolenic (18:3 n-3) acids for 10 wk. On d 20 of pregnancy, the animals from each group were killed. We determined the fatty acid profiles in plasma, brain, and liver microsomes of pregnant rats, as well as in placenta and fetal liver and brain. No changes were found in the number of fetuses of the pregnant rats. Trans fatty acids were incorporated in high concentrations in placenta and in maternal and fetal tissues, except brain, strongly elevating the linoleic acid proportion and lowering that of docosahexaenoic acid. The delta-6 fatty-acid desaturase activity in the liver microsomes of the pregnant rats was inhibited by trans isomers. In conclusion, high intakes of trans fatty acids partially inhibit liver delta-6 fatty-acid desaturase in pregnant rats, which may explain, in part, the low concentrations of docosahexaenoic acid in pregnant and fetal tissues. However, the fatty acid composition of both fetal and pregnant rat brain remains mostly unaffected regardless of the dietary trans fatty acid content.</description><subject>alpha-Linolenic Acid - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Dietary Fats - pharmacology</subject><subject>Docosahexaenoic Acids - blood</subject><subject>Docosahexaenoic Acids - metabolism</subject><subject>Fatty Acids - administration & dosage</subject><subject>Fatty Acids - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Linoleic Acid - pharmacology</subject><subject>Liver - metabolism</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>Pregnancy</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vertebrates: reproduction</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkctuHCEQRVHkKB7b-QWLReRdO0VDv5aR45dkKZt43aouIMbqgTEwkWeZPzfziBMWFIhzKXFgjAu4FDXIr1BGqxqo6u1qO1XbKj6whWhk2SjVHbEFgBSVHIb-mJ2k9AwgVNOrT-xYQNsp2QwL9ue7MxnjhueIPnGLOW84ktOJo7WGMteBQsIn84rGB0e7Q07Bk_Elk10oMef5asa0RI5e89n9NpFP68x9yHyKWI6D5atofnn0ecfY0nXmJZ_O2EeLczKfD_WUPd5c_7y6qx5-3N5ffXuoSA6Qq7pvaCJdK62QlKbOYle3PTQNkhCkRHmPMUpp3UoCi0oPyorJkhSA2EzylF3s713F8LI2KY9Ll8jMM3oT1mnsoB9UO9QF7PcgxZBSNHZcRbcsjkYB41b_-Ff_-K5_3Okv0fNDj_W0NPq_4N53Ab4cAEyEsy3SyaV_nAQoXyTfAJXajzI</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>LARQUE, E</creator><creator>PEREZ-LLAMAS, F</creator><creator>PUERTA, V</creator><creator>GIRON, M. D</creator><creator>SUAREZ, M. D</creator><creator>ZAMORA, S</creator><creator>GIL, A</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000201</creationdate><title>Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats</title><author>LARQUE, E ; PEREZ-LLAMAS, F ; PUERTA, V ; GIRON, M. D ; SUAREZ, M. D ; ZAMORA, S ; GIL, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-285cbcd24d4ac4dc7fa7268055ac11c41435ee44dd63c0fa4d94f1bfc310aa5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>alpha-Linolenic Acid - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Dietary Fats - pharmacology</topic><topic>Docosahexaenoic Acids - blood</topic><topic>Docosahexaenoic Acids - metabolism</topic><topic>Fatty Acids - administration & dosage</topic><topic>Fatty Acids - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Linoleic Acid - pharmacology</topic><topic>Liver - metabolism</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>Pregnancy</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LARQUE, E</creatorcontrib><creatorcontrib>PEREZ-LLAMAS, F</creatorcontrib><creatorcontrib>PUERTA, V</creatorcontrib><creatorcontrib>GIRON, M. D</creatorcontrib><creatorcontrib>SUAREZ, M. D</creatorcontrib><creatorcontrib>ZAMORA, S</creatorcontrib><creatorcontrib>GIL, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LARQUE, E</au><au>PEREZ-LLAMAS, F</au><au>PUERTA, V</au><au>GIRON, M. D</au><au>SUAREZ, M. D</au><au>ZAMORA, S</au><au>GIL, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats</atitle><jtitle>Pediatric research</jtitle><addtitle>Pediatr Res</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>47</volume><issue>2</issue><spage>278</spage><epage>283</epage><pages>278-283</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>The aim of the present study was to investigate the maternal-fetal transport, incorporation, and effects on liver delta-6 fatty-acid desaturase activity of dietary trans fatty acids in pregnant rats. Three groups of six rats each were fed three experimental diets containing approximately 0%, 15%, and 30% of trans fatty acids but containing the same proportion of linoleic (18:2 n-6) and a-linolenic (18:3 n-3) acids for 10 wk. On d 20 of pregnancy, the animals from each group were killed. We determined the fatty acid profiles in plasma, brain, and liver microsomes of pregnant rats, as well as in placenta and fetal liver and brain. No changes were found in the number of fetuses of the pregnant rats. Trans fatty acids were incorporated in high concentrations in placenta and in maternal and fetal tissues, except brain, strongly elevating the linoleic acid proportion and lowering that of docosahexaenoic acid. The delta-6 fatty-acid desaturase activity in the liver microsomes of the pregnant rats was inhibited by trans isomers. In conclusion, high intakes of trans fatty acids partially inhibit liver delta-6 fatty-acid desaturase in pregnant rats, which may explain, in part, the low concentrations of docosahexaenoic acid in pregnant and fetal tissues. However, the fatty acid composition of both fetal and pregnant rat brain remains mostly unaffected regardless of the dietary trans fatty acid content.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10674359</pmid><doi>10.1203/00006450-200002000-00021</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 2000-02, Vol.47 (2), p.278-283 |
| issn | 0031-3998 1530-0447 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70894692 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | alpha-Linolenic Acid - pharmacology Animals Biological and medical sciences Brain - metabolism Dietary Fats - pharmacology Docosahexaenoic Acids - blood Docosahexaenoic Acids - metabolism Fatty Acids - administration & dosage Fatty Acids - pharmacology Female Fundamental and applied biological sciences. Psychology Linoleic Acid - pharmacology Liver - metabolism Mother. Fetoplacental unit. Mammary gland. Milk Pregnancy Pregnancy. Parturition. Lactation Rats Rats, Wistar Vertebrates: reproduction |
| title | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T12%3A38%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dietary%20trans%20fatty%20acids%20affect%20docosahexaenoic%20acid%20concentrations%20in%20plasma%20and%20liver%20but%20not%20brain%20of%20pregnant%20and%20fetal%20rats&rft.jtitle=Pediatric%20research&rft.au=LARQUE,%20E&rft.date=2000-02-01&rft.volume=47&rft.issue=2&rft.spage=278&rft.epage=283&rft.pages=278-283&rft.issn=0031-3998&rft.eissn=1530-0447&rft.coden=PEREBL&rft_id=info:doi/10.1203/00006450-200002000-00021&rft_dat=%3Cproquest_cross%3E70894692%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70894692&rft_id=info:pmid/10674359&rfr_iscdi=true |