An Underfeeding Study in Healthy Men and Women Provides Further Evidence of Impaired Regulation of Energy Expenditure in Old Age
The effect of aging on energy regulation remains controversial. We compared the effects of underfeeding on changes in energy expenditure and respiratory quotient in young normal weight men and women [YNW, age 25.7 ± 3.2 y(sd), body mass index (BMI) 23.1 ± 1.6 kg/m2], young overweight men and women (...
Gespeichert in:
| Veröffentlicht in: | The Journal of nutrition 2001-06, Vol.131 (6), p.1833-1838 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1838 |
|---|---|
| container_issue | 6 |
| container_start_page | 1833 |
| container_title | The Journal of nutrition |
| container_volume | 131 |
| creator | Das, Sai Krupa Moriguti, Julio C. McCrory, Megan A. Saltzman, Edward Mosunic, Christopher Greenberg, Andrew S. Roberts, Susan B. |
| description | The effect of aging on energy regulation remains controversial. We compared the effects of underfeeding on changes in energy expenditure and respiratory quotient in young normal weight men and women [YNW, age 25.7 ± 3.2 y(sd), body mass index (BMI) 23.1 ± 1.6 kg/m2], young overweight men and women (YOW, age 26.1 ± 3.5 y, BMI 27.7 ± 2.1 kg/m2) and older (OLD) men and women (age 68.4 ± 3.3 y, BMI 27.4 ± 3.4 kg/m2). The thermic effect of feeding (TEF) during weight maintenance, and changes in resting energy expenditure (REE) and respiratory quotient were determined in response to undereating by an average 3.75 MJ/d for 6 wk. In addition, body composition was measured. No significant differences among the groups were observed in TEF, fasting and postprandial respiratory quotient, or the change in fasting respiratory quotient with underfeeding. However, REE adjusted for fat-free mass and fat mass was significantly lower in OLD subjects compared with YNW and YOW subjects (P < 0.05). In addition, the REE response to weight change was significantly attenuated in the OLD subjects (P = 0.023). These data suggest that the responsiveness of energy expenditure to negative energy balance is attenuated in old age, and provide further support for the hypothesis that mechanisms of energy regulation are broadly disregulated in old age. |
| doi_str_mv | 10.1093/jn/131.6.1833 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70894446</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022316622138010</els_id><sourcerecordid>70894446</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-8e695586c8b3b50ce60cb4e15b53aff8a9c09d25c3d692b64e96ebd904c140263</originalsourceid><addsrcrecordid>eNqFkc1r2zAYh8VYWdNux12LDqM3p5L1EekYSroWWjq2lR2FLL1OFWw5lezS3Pan1yaB7VJ6ej94-PHyPgh9pWROiWYXm3hBGZ3LOVWMfUAzKjgtJCXkI5oRUpYFo1Ieo5OcN4QQyrX6hI4pZUqQhZihv8uIH6KHVAP4ENf4Vz_4HQ4RX4Nt-scdvoOIbfT4T9eO3Y_UPQcPGV8NqX-EhFfTGB3grsY37daGBB7_hPXQ2D50cVqvIqT1Dq9ethB96IcEU_594_FyDZ_RUW2bDF8O9RQ9XK1-X14Xt_ffby6Xt4XjTPaFAqmFUNKpilWCOJDEVRyoqASzda2sdkT7UjjmpS4ryUFLqLwm3FFOSslO0fk-d5u6pwFyb9qQHTSNjdAN2SyI0pzz90GquOZSLkaw2IMudTknqM02hdamnaHETG7MJprRjZFmcjPyZ4fgoWrB_6MPMkbg2wGw2dmmTja6kP9L5UILOmKLPQbju54DJJNdmBT48feuN74Lb1zwCol1qV4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18494667</pqid></control><display><type>article</type><title>An Underfeeding Study in Healthy Men and Women Provides Further Evidence of Impaired Regulation of Energy Expenditure in Old Age</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Das, Sai Krupa ; Moriguti, Julio C. ; McCrory, Megan A. ; Saltzman, Edward ; Mosunic, Christopher ; Greenberg, Andrew S. ; Roberts, Susan B.</creator><creatorcontrib>Das, Sai Krupa ; Moriguti, Julio C. ; McCrory, Megan A. ; Saltzman, Edward ; Mosunic, Christopher ; Greenberg, Andrew S. ; Roberts, Susan B.</creatorcontrib><description>The effect of aging on energy regulation remains controversial. We compared the effects of underfeeding on changes in energy expenditure and respiratory quotient in young normal weight men and women [YNW, age 25.7 ± 3.2 y(sd), body mass index (BMI) 23.1 ± 1.6 kg/m2], young overweight men and women (YOW, age 26.1 ± 3.5 y, BMI 27.7 ± 2.1 kg/m2) and older (OLD) men and women (age 68.4 ± 3.3 y, BMI 27.4 ± 3.4 kg/m2). The thermic effect of feeding (TEF) during weight maintenance, and changes in resting energy expenditure (REE) and respiratory quotient were determined in response to undereating by an average 3.75 MJ/d for 6 wk. In addition, body composition was measured. No significant differences among the groups were observed in TEF, fasting and postprandial respiratory quotient, or the change in fasting respiratory quotient with underfeeding. However, REE adjusted for fat-free mass and fat mass was significantly lower in OLD subjects compared with YNW and YOW subjects (P < 0.05). In addition, the REE response to weight change was significantly attenuated in the OLD subjects (P = 0.023). These data suggest that the responsiveness of energy expenditure to negative energy balance is attenuated in old age, and provide further support for the hypothesis that mechanisms of energy regulation are broadly disregulated in old age.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/131.6.1833</identifier><identifier>PMID: 11385075</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Adult ; Aged ; aging ; Aging - physiology ; Analysis of Variance ; Biological and medical sciences ; body composition ; Body Mass Index ; Body Weight ; Energy Intake ; energy metabolism ; Energy Metabolism - physiology ; Fasting ; Feeding Behavior ; Female ; Humans ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Life Style ; Male ; Medical sciences ; Middle Aged ; respiratory quotient ; Traumas. Diseases due to physical agents ; Weight Loss</subject><ispartof>The Journal of nutrition, 2001-06, Vol.131 (6), p.1833-1838</ispartof><rights>2001 American Society for Nutrition.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-8e695586c8b3b50ce60cb4e15b53aff8a9c09d25c3d692b64e96ebd904c140263</citedby><cites>FETCH-LOGICAL-c436t-8e695586c8b3b50ce60cb4e15b53aff8a9c09d25c3d692b64e96ebd904c140263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1045951$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11385075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Das, Sai Krupa</creatorcontrib><creatorcontrib>Moriguti, Julio C.</creatorcontrib><creatorcontrib>McCrory, Megan A.</creatorcontrib><creatorcontrib>Saltzman, Edward</creatorcontrib><creatorcontrib>Mosunic, Christopher</creatorcontrib><creatorcontrib>Greenberg, Andrew S.</creatorcontrib><creatorcontrib>Roberts, Susan B.</creatorcontrib><title>An Underfeeding Study in Healthy Men and Women Provides Further Evidence of Impaired Regulation of Energy Expenditure in Old Age</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The effect of aging on energy regulation remains controversial. We compared the effects of underfeeding on changes in energy expenditure and respiratory quotient in young normal weight men and women [YNW, age 25.7 ± 3.2 y(sd), body mass index (BMI) 23.1 ± 1.6 kg/m2], young overweight men and women (YOW, age 26.1 ± 3.5 y, BMI 27.7 ± 2.1 kg/m2) and older (OLD) men and women (age 68.4 ± 3.3 y, BMI 27.4 ± 3.4 kg/m2). The thermic effect of feeding (TEF) during weight maintenance, and changes in resting energy expenditure (REE) and respiratory quotient were determined in response to undereating by an average 3.75 MJ/d for 6 wk. In addition, body composition was measured. No significant differences among the groups were observed in TEF, fasting and postprandial respiratory quotient, or the change in fasting respiratory quotient with underfeeding. However, REE adjusted for fat-free mass and fat mass was significantly lower in OLD subjects compared with YNW and YOW subjects (P < 0.05). In addition, the REE response to weight change was significantly attenuated in the OLD subjects (P = 0.023). These data suggest that the responsiveness of energy expenditure to negative energy balance is attenuated in old age, and provide further support for the hypothesis that mechanisms of energy regulation are broadly disregulated in old age.</description><subject>Adult</subject><subject>Aged</subject><subject>aging</subject><subject>Aging - physiology</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>body composition</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Energy Intake</subject><subject>energy metabolism</subject><subject>Energy Metabolism - physiology</subject><subject>Fasting</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Humans</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Life Style</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>respiratory quotient</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Weight Loss</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1r2zAYh8VYWdNux12LDqM3p5L1EekYSroWWjq2lR2FLL1OFWw5lezS3Pan1yaB7VJ6ej94-PHyPgh9pWROiWYXm3hBGZ3LOVWMfUAzKjgtJCXkI5oRUpYFo1Ieo5OcN4QQyrX6hI4pZUqQhZihv8uIH6KHVAP4ENf4Vz_4HQ4RX4Nt-scdvoOIbfT4T9eO3Y_UPQcPGV8NqX-EhFfTGB3grsY37daGBB7_hPXQ2D50cVqvIqT1Dq9ethB96IcEU_594_FyDZ_RUW2bDF8O9RQ9XK1-X14Xt_ffby6Xt4XjTPaFAqmFUNKpilWCOJDEVRyoqASzda2sdkT7UjjmpS4ryUFLqLwm3FFOSslO0fk-d5u6pwFyb9qQHTSNjdAN2SyI0pzz90GquOZSLkaw2IMudTknqM02hdamnaHETG7MJprRjZFmcjPyZ4fgoWrB_6MPMkbg2wGw2dmmTja6kP9L5UILOmKLPQbju54DJJNdmBT48feuN74Lb1zwCol1qV4</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Das, Sai Krupa</creator><creator>Moriguti, Julio C.</creator><creator>McCrory, Megan A.</creator><creator>Saltzman, Edward</creator><creator>Mosunic, Christopher</creator><creator>Greenberg, Andrew S.</creator><creator>Roberts, Susan B.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>An Underfeeding Study in Healthy Men and Women Provides Further Evidence of Impaired Regulation of Energy Expenditure in Old Age</title><author>Das, Sai Krupa ; Moriguti, Julio C. ; McCrory, Megan A. ; Saltzman, Edward ; Mosunic, Christopher ; Greenberg, Andrew S. ; Roberts, Susan B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-8e695586c8b3b50ce60cb4e15b53aff8a9c09d25c3d692b64e96ebd904c140263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>aging</topic><topic>Aging - physiology</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>body composition</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Energy Intake</topic><topic>energy metabolism</topic><topic>Energy Metabolism - physiology</topic><topic>Fasting</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Humans</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Life Style</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>respiratory quotient</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Das, Sai Krupa</creatorcontrib><creatorcontrib>Moriguti, Julio C.</creatorcontrib><creatorcontrib>McCrory, Megan A.</creatorcontrib><creatorcontrib>Saltzman, Edward</creatorcontrib><creatorcontrib>Mosunic, Christopher</creatorcontrib><creatorcontrib>Greenberg, Andrew S.</creatorcontrib><creatorcontrib>Roberts, Susan B.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Das, Sai Krupa</au><au>Moriguti, Julio C.</au><au>McCrory, Megan A.</au><au>Saltzman, Edward</au><au>Mosunic, Christopher</au><au>Greenberg, Andrew S.</au><au>Roberts, Susan B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Underfeeding Study in Healthy Men and Women Provides Further Evidence of Impaired Regulation of Energy Expenditure in Old Age</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>131</volume><issue>6</issue><spage>1833</spage><epage>1838</epage><pages>1833-1838</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>The effect of aging on energy regulation remains controversial. We compared the effects of underfeeding on changes in energy expenditure and respiratory quotient in young normal weight men and women [YNW, age 25.7 ± 3.2 y(sd), body mass index (BMI) 23.1 ± 1.6 kg/m2], young overweight men and women (YOW, age 26.1 ± 3.5 y, BMI 27.7 ± 2.1 kg/m2) and older (OLD) men and women (age 68.4 ± 3.3 y, BMI 27.4 ± 3.4 kg/m2). The thermic effect of feeding (TEF) during weight maintenance, and changes in resting energy expenditure (REE) and respiratory quotient were determined in response to undereating by an average 3.75 MJ/d for 6 wk. In addition, body composition was measured. No significant differences among the groups were observed in TEF, fasting and postprandial respiratory quotient, or the change in fasting respiratory quotient with underfeeding. However, REE adjusted for fat-free mass and fat mass was significantly lower in OLD subjects compared with YNW and YOW subjects (P < 0.05). In addition, the REE response to weight change was significantly attenuated in the OLD subjects (P = 0.023). These data suggest that the responsiveness of energy expenditure to negative energy balance is attenuated in old age, and provide further support for the hypothesis that mechanisms of energy regulation are broadly disregulated in old age.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>11385075</pmid><doi>10.1093/jn/131.6.1833</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3166 |
| ispartof | The Journal of nutrition, 2001-06, Vol.131 (6), p.1833-1838 |
| issn | 0022-3166 1541-6100 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70894446 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged aging Aging - physiology Analysis of Variance Biological and medical sciences body composition Body Mass Index Body Weight Energy Intake energy metabolism Energy Metabolism - physiology Fasting Feeding Behavior Female Humans Injuries of the nervous system and the skull. Diseases due to physical agents Life Style Male Medical sciences Middle Aged respiratory quotient Traumas. Diseases due to physical agents Weight Loss |
| title | An Underfeeding Study in Healthy Men and Women Provides Further Evidence of Impaired Regulation of Energy Expenditure in Old Age |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T05%3A39%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20Underfeeding%20Study%20in%20Healthy%20Men%20and%20Women%20Provides%20Further%20Evidence%20of%20Impaired%20Regulation%20of%20Energy%20Expenditure%20in%20Old%20Age&rft.jtitle=The%20Journal%20of%20nutrition&rft.au=Das,%20Sai%20Krupa&rft.date=2001-06-01&rft.volume=131&rft.issue=6&rft.spage=1833&rft.epage=1838&rft.pages=1833-1838&rft.issn=0022-3166&rft.eissn=1541-6100&rft.coden=JONUAI&rft_id=info:doi/10.1093/jn/131.6.1833&rft_dat=%3Cproquest_cross%3E70894446%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18494667&rft_id=info:pmid/11385075&rft_els_id=S0022316622138010&rfr_iscdi=true |