Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

The development of the human immunodeficiency virus-1 (HIV-1)/simian immunodeficiency virus (SIV) chimeric virus macaque model (SHIV) permits the in vivo evaluation of anti-HIV-1 envelope glycoprotein immune responses 1 , 2 , 3 . Using this model, others, and we have shown that passively infused ant...

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Veröffentlicht in:	Nature medicine 2000-02, Vol.6 (2), p.207-210
Hauptverfasser:	Mascola, John R., Stiegler, Gabriela, VanCott, Thomas C., Katinger, Hermann, Carpenter, Calvin B., Hanson, Chris E., Beary, Holly, Hayes, Deborah, Frankel, Sarah S., Birx, Deborah L., Lewis, Mark G.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Antibodies, Monoclonal - administration & dosage Biomedical and Life Sciences Biomedicine Cancer Research Chimera Disease transmission Female HIV HIV Antibodies - analysis HIV Antibodies - blood HIV-1 - genetics HIV-1 - immunology Human immunodeficiency virus human immunodeficiency virus 1 Immune system Immunity, Mucosal Immunization, Passive Infections Infectious Diseases Macaca Macaca mulatta Medicine Metabolic Diseases Molecular Medicine Monoclonal antibodies Neurosciences Neutralization Tests Plasma Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Acquired Immunodeficiency Syndrome - transmission simian immunodeficiency virus Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - immunology Vagina Vagina - immunology
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