A mechanistic analysis of carrier-mediated oral delivery of protein therapeutics

This article summarizes the results of a theoretical analysis of protein absorption into the systemic circulation from the small intestine, with and without molecular ‘carriers’ designed to enhance absorption. The predictions are compared with experimental systemic protein concentrations following i...

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Veröffentlicht in:	Journal of controlled release 2000-02, Vol.64 (1), p.217-228
Hauptverfasser:	Stoll, Brian R., Leipold, Harry R., Milstein, Sam, Edwards, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption - drug effects Administration, Oral Biological and medical sciences Biological Availability Drug Carriers Epithelium - drug effects Epithelium - physiology General pharmacology Human Growth Hormone - pharmacokinetics Insulin - pharmacokinetics Interferon-alpha - pharmacokinetics Intestines - drug effects Intestines - physiology Medical sciences Models, Theoretical Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Recombinant Proteins Time Factors
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