The relationship between genetic aberrations as detected by Comparative Genomic Hybridization and vascularization in glioblastoma xenografts
Angiogenesis is of vital importance for the growth of solid tumors and constitutes a target for anti-cancer therapy. Glioblastomas (GBMs) are histologically characterized by striking microvascular proliferation. The identification of the mechanism of angiogenesis is of major importance for the furth...
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| Veröffentlicht in: | Journal of neuro-oncology 2001, Vol.51 (2), p.121-127 |
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| creator | GILHUIS, H. Jacobus BERNSEN, Hans J. J. A JEUKEN, Judith W. M WESSELING, Pieter SPRENGER, Sandra H. E KERSTENS, Harold M. J WIEGANT, Joop BOERMAN, Rudolf H |
| description | Angiogenesis is of vital importance for the growth of solid tumors and constitutes a target for anti-cancer therapy. Glioblastomas (GBMs) are histologically characterized by striking microvascular proliferation. The identification of the mechanism of angiogenesis is of major importance for the further development of anti-angiogenic therapy. Tumor angiogenesis might be the result of a combination of local tissue conditions (especially hypoxia) and specific genetic alterations acquired during oncogenesis. In order to investigate the relationship between genetic aberrations and tumor angiogenesis in GBM xenograft lines, the genetic alterations were examined by Comparative Genomic Hybridization (CGH). Two vascular phenotypes of GBM xenografts could be identified: a well vascularized and a poorly vascularized type. In this model, the poorly vascularized type had a larger number of genetic alterations. However, there was no unequivocal correlation between angiogenesis, growth rate and patterns of genetic alterations as detected by CGH. |
| doi_str_mv | 10.1023/A:1010675831154 |
| format | Article |
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Jacobus ; BERNSEN, Hans J. J. A ; JEUKEN, Judith W. M ; WESSELING, Pieter ; SPRENGER, Sandra H. E ; KERSTENS, Harold M. J ; WIEGANT, Joop ; BOERMAN, Rudolf H</creator><creatorcontrib>GILHUIS, H. Jacobus ; BERNSEN, Hans J. J. A ; JEUKEN, Judith W. M ; WESSELING, Pieter ; SPRENGER, Sandra H. E ; KERSTENS, Harold M. J ; WIEGANT, Joop ; BOERMAN, Rudolf H</creatorcontrib><description>Angiogenesis is of vital importance for the growth of solid tumors and constitutes a target for anti-cancer therapy. Glioblastomas (GBMs) are histologically characterized by striking microvascular proliferation. The identification of the mechanism of angiogenesis is of major importance for the further development of anti-angiogenic therapy. Tumor angiogenesis might be the result of a combination of local tissue conditions (especially hypoxia) and specific genetic alterations acquired during oncogenesis. In order to investigate the relationship between genetic aberrations and tumor angiogenesis in GBM xenograft lines, the genetic alterations were examined by Comparative Genomic Hybridization (CGH). Two vascular phenotypes of GBM xenografts could be identified: a well vascularized and a poorly vascularized type. In this model, the poorly vascularized type had a larger number of genetic alterations. However, there was no unequivocal correlation between angiogenesis, growth rate and patterns of genetic alterations as detected by CGH.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1023/A:1010675831154</identifier><identifier>PMID: 11386408</identifier><identifier>CODEN: JNODD2</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Adult ; Aged ; Animals ; Biological and medical sciences ; Brain Neoplasms - blood supply ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; Chromosome Aberrations ; Chromosome Mapping ; DNA, Neoplasm - genetics ; Female ; Glioblastoma - blood supply ; Glioblastoma - genetics ; Glioblastoma - pathology ; Humans ; Loss of Heterozygosity ; Male ; Medical sciences ; Mice ; Mice, Nude ; Middle Aged ; Neovascularization, Pathologic ; Neurology ; Nucleic Acid Hybridization - methods ; Phenotype ; Transplantation, Heterologous ; Tumor Cells, Cultured ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Journal of neuro-oncology, 2001, Vol.51 (2), p.121-127</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Jan 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=973207$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11386408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GILHUIS, H. Jacobus</creatorcontrib><creatorcontrib>BERNSEN, Hans J. J. A</creatorcontrib><creatorcontrib>JEUKEN, Judith W. M</creatorcontrib><creatorcontrib>WESSELING, Pieter</creatorcontrib><creatorcontrib>SPRENGER, Sandra H. E</creatorcontrib><creatorcontrib>KERSTENS, Harold M. J</creatorcontrib><creatorcontrib>WIEGANT, Joop</creatorcontrib><creatorcontrib>BOERMAN, Rudolf H</creatorcontrib><title>The relationship between genetic aberrations as detected by Comparative Genomic Hybridization and vascularization in glioblastoma xenografts</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><description>Angiogenesis is of vital importance for the growth of solid tumors and constitutes a target for anti-cancer therapy. Glioblastomas (GBMs) are histologically characterized by striking microvascular proliferation. The identification of the mechanism of angiogenesis is of major importance for the further development of anti-angiogenic therapy. Tumor angiogenesis might be the result of a combination of local tissue conditions (especially hypoxia) and specific genetic alterations acquired during oncogenesis. In order to investigate the relationship between genetic aberrations and tumor angiogenesis in GBM xenograft lines, the genetic alterations were examined by Comparative Genomic Hybridization (CGH). Two vascular phenotypes of GBM xenografts could be identified: a well vascularized and a poorly vascularized type. In this model, the poorly vascularized type had a larger number of genetic alterations. However, there was no unequivocal correlation between angiogenesis, growth rate and patterns of genetic alterations as detected by CGH.</description><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - blood supply</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - pathology</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Mapping</subject><subject>DNA, Neoplasm - genetics</subject><subject>Female</subject><subject>Glioblastoma - blood supply</subject><subject>Glioblastoma - genetics</subject><subject>Glioblastoma - pathology</subject><subject>Humans</subject><subject>Loss of Heterozygosity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Middle Aged</subject><subject>Neovascularization, Pathologic</subject><subject>Neurology</subject><subject>Nucleic Acid Hybridization - methods</subject><subject>Phenotype</subject><subject>Transplantation, Heterologous</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors of the nervous system. 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Jacobus</au><au>BERNSEN, Hans J. J. A</au><au>JEUKEN, Judith W. M</au><au>WESSELING, Pieter</au><au>SPRENGER, Sandra H. E</au><au>KERSTENS, Harold M. J</au><au>WIEGANT, Joop</au><au>BOERMAN, Rudolf H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between genetic aberrations as detected by Comparative Genomic Hybridization and vascularization in glioblastoma xenografts</atitle><jtitle>Journal of neuro-oncology</jtitle><addtitle>J Neurooncol</addtitle><date>2001</date><risdate>2001</risdate><volume>51</volume><issue>2</issue><spage>121</spage><epage>127</epage><pages>121-127</pages><issn>0167-594X</issn><eissn>1573-7373</eissn><coden>JNODD2</coden><abstract>Angiogenesis is of vital importance for the growth of solid tumors and constitutes a target for anti-cancer therapy. Glioblastomas (GBMs) are histologically characterized by striking microvascular proliferation. The identification of the mechanism of angiogenesis is of major importance for the further development of anti-angiogenic therapy. Tumor angiogenesis might be the result of a combination of local tissue conditions (especially hypoxia) and specific genetic alterations acquired during oncogenesis. In order to investigate the relationship between genetic aberrations and tumor angiogenesis in GBM xenograft lines, the genetic alterations were examined by Comparative Genomic Hybridization (CGH). Two vascular phenotypes of GBM xenografts could be identified: a well vascularized and a poorly vascularized type. In this model, the poorly vascularized type had a larger number of genetic alterations. However, there was no unequivocal correlation between angiogenesis, growth rate and patterns of genetic alterations as detected by CGH.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>11386408</pmid><doi>10.1023/A:1010675831154</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0167-594X |
| ispartof | Journal of neuro-oncology, 2001, Vol.51 (2), p.121-127 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Animals Biological and medical sciences Brain Neoplasms - blood supply Brain Neoplasms - genetics Brain Neoplasms - pathology Chromosome Aberrations Chromosome Mapping DNA, Neoplasm - genetics Female Glioblastoma - blood supply Glioblastoma - genetics Glioblastoma - pathology Humans Loss of Heterozygosity Male Medical sciences Mice Mice, Nude Middle Aged Neovascularization, Pathologic Neurology Nucleic Acid Hybridization - methods Phenotype Transplantation, Heterologous Tumor Cells, Cultured Tumors of the nervous system. Phacomatoses |
| title | The relationship between genetic aberrations as detected by Comparative Genomic Hybridization and vascularization in glioblastoma xenografts |
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