Bartter syndrome in a neonate : early treatment with indomethacin
The neonatal form of Bartter syndrome is characterized by intrauterine onset of polyuria leading to severe polyhydramnios. We report a patient with the early onset of the syndrome and a similar history in a previous sibling who died in early neonatal life. The patient is a female product of 33 weeks...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2000-02, Vol.14 (2), p.143-145 |
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| creator | MOURANI, C. C SANJAD, S. A AKATCHERIAN, C. Y |
| description | The neonatal form of Bartter syndrome is characterized by intrauterine onset of polyuria leading to severe polyhydramnios. We report a patient with the early onset of the syndrome and a similar history in a previous sibling who died in early neonatal life. The patient is a female product of 33 weeks of gestation complicated by severe polyhydramnios. Her birth weight was 2,100 g. Polyuria led to severe dehydration on the 3rd day of life. Laboratory studies showed hypokalemia, hyponatremia, and elevated plasma levels of renin and aldosterone. Hypercalciuria was associated with echographic evidence of nephrocalcinosis. Indomethacin therapy resulted in a significant reduction in urine volume and correction of biochemical abnormalities. Growth and development are satisfactory after 4 years of indomethacin therapy, but nephrocalcinosis remains unchanged. |
| doi_str_mv | 10.1007/s004670050030 |
| format | Article |
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Growth and development are satisfactory after 4 years of indomethacin therapy, but nephrocalcinosis remains unchanged.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s004670050030</identifier><identifier>PMID: 10684365</identifier><identifier>CODEN: PENED3</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Bartter Syndrome - complications ; Bartter Syndrome - diagnostic imaging ; Bartter Syndrome - drug therapy ; Biological and medical sciences ; Endocrinopathies ; Female ; Humans ; Indomethacin - therapeutic use ; Infant, Newborn ; Infant, Premature ; Medical sciences ; Nephrocalcinosis - diagnostic imaging ; Nephrocalcinosis - drug therapy ; Nephrocalcinosis - etiology ; Non tumoral diseases. Target tissue resistance. 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Indomethacin therapy resulted in a significant reduction in urine volume and correction of biochemical abnormalities. Growth and development are satisfactory after 4 years of indomethacin therapy, but nephrocalcinosis remains unchanged.</description><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Bartter Syndrome - complications</subject><subject>Bartter Syndrome - diagnostic imaging</subject><subject>Bartter Syndrome - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Humans</subject><subject>Indomethacin - therapeutic use</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Medical sciences</subject><subject>Nephrocalcinosis - diagnostic imaging</subject><subject>Nephrocalcinosis - drug therapy</subject><subject>Nephrocalcinosis - etiology</subject><subject>Non tumoral diseases. Target tissue resistance. 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| subjects | Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Bartter Syndrome - complications Bartter Syndrome - diagnostic imaging Bartter Syndrome - drug therapy Biological and medical sciences Endocrinopathies Female Humans Indomethacin - therapeutic use Infant, Newborn Infant, Premature Medical sciences Nephrocalcinosis - diagnostic imaging Nephrocalcinosis - drug therapy Nephrocalcinosis - etiology Non tumoral diseases. Target tissue resistance. Benign neoplasms Ultrasonography |
| title | Bartter syndrome in a neonate : early treatment with indomethacin |
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