Dicyclomine, an M1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model

The rat subdural hematoma (SDH) model produces a zone of ischemic brain damage within the hemisphere beneath the SDH. Previous studies have measured large increases in extracellular acetylcholine during cerebral ischemia in the rat. We examined infarct volume after selectively blocking muscarinic M1...

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Veröffentlicht in:	Brain research 2000-01, Vol.852 (1), p.37-44
Hauptverfasser:	Jiang, Zheng-Wu, Gong, Qin-Zhi, Di, Xiao, Zhu, Jiepei, Lyeth, Bruce G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Animals Biological and medical sciences Blood Pressure - drug effects Cerebral Infarction - etiology Cerebral Infarction - pathology Cerebral Infarction - physiopathology Cerebrovascular Circulation - drug effects Dicyclomine Dicyclomine - pharmacology Hematoma, Subdural - complications Injuries of the nervous system and the skull. Diseases due to physical agents Intracranial Pressure - drug effects Male Medical sciences Muscarinic Muscarinic Antagonists - pharmacology Rat Rats Rats, Sprague-Dawley Receptor Traumas. Diseases due to physical agents Traumatic brain injury
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