Dicyclomine, an M1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model
The rat subdural hematoma (SDH) model produces a zone of ischemic brain damage within the hemisphere beneath the SDH. Previous studies have measured large increases in extracellular acetylcholine during cerebral ischemia in the rat. We examined infarct volume after selectively blocking muscarinic M1...
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| Veröffentlicht in: | Brain research 2000-01, Vol.852 (1), p.37-44 |
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| creator | Jiang, Zheng-Wu Gong, Qin-Zhi Di, Xiao Zhu, Jiepei Lyeth, Bruce G. |
| description | The rat subdural hematoma (SDH) model produces a zone of ischemic brain damage within the hemisphere beneath the SDH. Previous studies have measured large increases in extracellular acetylcholine during cerebral ischemia in the rat. We examined infarct volume after selectively blocking muscarinic M1 receptors with dicyclomine during SDH. Rats were anesthetized with isoflurane (2%), intubated, and femoral artery and vein cannulated. Autologous blood (0.375 ml) was injected (0.05 ml/min) under the dura of the right parietal cortex. Dicyclomine (5 mg/kg, i.v.) was injected at 5 min after and again at 2 h after completion of the subdural blood infusion. Blood pressure and intracranial pressure (ICP) were continuously measured. At 4 h after SDH rats were euthanized, brains sectioned, and immunoreacted with glia fibrillary acidic protein. Cortical infarct volume was quantified in coronal brain sections at 0.7-mm intervals from +1.0 mm to −3.9 mm relative to bregma. Infarct volume in drug-treated rats (
n=10) 22.1±6.99 mm
3 was significantly smaller (
p |
| doi_str_mv | 10.1016/S0006-8993(99)02230-1 |
| format | Article |
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n=10) 22.1±6.99 mm
3 was significantly smaller (
p<0.02) than vehicle treated rats (
n=10) 56.7±9.59 mm
3. ICP, blood pressure and cerebral perfusion pressure were not significantly different between groups. These data suggest that activation of M1 muscarinic receptors during an ischemic event may contribute to the development of subsequent pathology.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(99)02230-1</identifier><identifier>PMID: 10661493</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Acetylcholine ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Cerebral Infarction - etiology ; Cerebral Infarction - pathology ; Cerebral Infarction - physiopathology ; Cerebrovascular Circulation - drug effects ; Dicyclomine ; Dicyclomine - pharmacology ; Hematoma, Subdural - complications ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Intracranial Pressure - drug effects ; Male ; Medical sciences ; Muscarinic ; Muscarinic Antagonists - pharmacology ; Rat ; Rats ; Rats, Sprague-Dawley ; Receptor ; Traumas. Diseases due to physical agents ; Traumatic brain injury</subject><ispartof>Brain research, 2000-01, Vol.852 (1), p.37-44</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-5da627afabce209cc053112e0718dd87eed2cdfa44e021f37a4dc0c2f4ba43a23</citedby><cites>FETCH-LOGICAL-c421t-5da627afabce209cc053112e0718dd87eed2cdfa44e021f37a4dc0c2f4ba43a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899399022301$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1226489$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10661493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Zheng-Wu</creatorcontrib><creatorcontrib>Gong, Qin-Zhi</creatorcontrib><creatorcontrib>Di, Xiao</creatorcontrib><creatorcontrib>Zhu, Jiepei</creatorcontrib><creatorcontrib>Lyeth, Bruce G.</creatorcontrib><title>Dicyclomine, an M1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The rat subdural hematoma (SDH) model produces a zone of ischemic brain damage within the hemisphere beneath the SDH. Previous studies have measured large increases in extracellular acetylcholine during cerebral ischemia in the rat. We examined infarct volume after selectively blocking muscarinic M1 receptors with dicyclomine during SDH. Rats were anesthetized with isoflurane (2%), intubated, and femoral artery and vein cannulated. Autologous blood (0.375 ml) was injected (0.05 ml/min) under the dura of the right parietal cortex. Dicyclomine (5 mg/kg, i.v.) was injected at 5 min after and again at 2 h after completion of the subdural blood infusion. Blood pressure and intracranial pressure (ICP) were continuously measured. At 4 h after SDH rats were euthanized, brains sectioned, and immunoreacted with glia fibrillary acidic protein. Cortical infarct volume was quantified in coronal brain sections at 0.7-mm intervals from +1.0 mm to −3.9 mm relative to bregma. Infarct volume in drug-treated rats (
n=10) 22.1±6.99 mm
3 was significantly smaller (
p<0.02) than vehicle treated rats (
n=10) 56.7±9.59 mm
3. ICP, blood pressure and cerebral perfusion pressure were not significantly different between groups. These data suggest that activation of M1 muscarinic receptors during an ischemic event may contribute to the development of subsequent pathology.</description><subject>Acetylcholine</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cerebral Infarction - etiology</subject><subject>Cerebral Infarction - pathology</subject><subject>Cerebral Infarction - physiopathology</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Dicyclomine</subject><subject>Dicyclomine - pharmacology</subject><subject>Hematoma, Subdural - complications</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Intracranial Pressure - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscarinic</subject><subject>Muscarinic Antagonists - pharmacology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Traumatic brain injury</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcluFDEQhi1ERIbAI4B8QBFIafDWi08oCkuQgjgAZ6umXA1G7XawuyPl7fFkRsAtp1KVvtr-n7FnUryWQnZvvgohumawVr-09pVQSotGPmAbOfSq6ZQRD9nmL3LMHpfyq6ZaW_GIHUvRddJYvWHwLuAtTimGmc44zPyz5HEtCDnMAWthgR9pDmU545n8ilR4mEfIuPCbNK2RasqBZ1h4Wbd-zTDxnxRhSRF4TJ6mJ-xohKnQ00M8Yd8_vP92cdlcffn46eL8qkGj5NK0HjrVwwhbJCUsomi1lIpELwfvh57IK_QjGENCyVH3YDwKVKPZgtGg9Ak73c-9zun3SmVxMRSkaYKZ0lpcLwZb_78flP3QD21rK9juQcyplEyju84hQr51UridCe7OBLdT2Fnr7kxwsvY9PyxYt5H8f1171Svw4gBAVXoaM8wYyj9Oqc4Mu_1v9xhV2W4CZVcw0IzkQyZcnE_hnkv-AHGypA4</recordid><startdate>20000103</startdate><enddate>20000103</enddate><creator>Jiang, Zheng-Wu</creator><creator>Gong, Qin-Zhi</creator><creator>Di, Xiao</creator><creator>Zhu, Jiepei</creator><creator>Lyeth, Bruce G.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20000103</creationdate><title>Dicyclomine, an M1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model</title><author>Jiang, Zheng-Wu ; Gong, Qin-Zhi ; Di, Xiao ; Zhu, Jiepei ; Lyeth, Bruce G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-5da627afabce209cc053112e0718dd87eed2cdfa44e021f37a4dc0c2f4ba43a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acetylcholine</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cerebral Infarction - etiology</topic><topic>Cerebral Infarction - pathology</topic><topic>Cerebral Infarction - physiopathology</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Dicyclomine</topic><topic>Dicyclomine - pharmacology</topic><topic>Hematoma, Subdural - complications</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Intracranial Pressure - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscarinic</topic><topic>Muscarinic Antagonists - pharmacology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Zheng-Wu</creatorcontrib><creatorcontrib>Gong, Qin-Zhi</creatorcontrib><creatorcontrib>Di, Xiao</creatorcontrib><creatorcontrib>Zhu, Jiepei</creatorcontrib><creatorcontrib>Lyeth, Bruce G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Zheng-Wu</au><au>Gong, Qin-Zhi</au><au>Di, Xiao</au><au>Zhu, Jiepei</au><au>Lyeth, Bruce G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dicyclomine, an M1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2000-01-03</date><risdate>2000</risdate><volume>852</volume><issue>1</issue><spage>37</spage><epage>44</epage><pages>37-44</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The rat subdural hematoma (SDH) model produces a zone of ischemic brain damage within the hemisphere beneath the SDH. Previous studies have measured large increases in extracellular acetylcholine during cerebral ischemia in the rat. We examined infarct volume after selectively blocking muscarinic M1 receptors with dicyclomine during SDH. Rats were anesthetized with isoflurane (2%), intubated, and femoral artery and vein cannulated. Autologous blood (0.375 ml) was injected (0.05 ml/min) under the dura of the right parietal cortex. Dicyclomine (5 mg/kg, i.v.) was injected at 5 min after and again at 2 h after completion of the subdural blood infusion. Blood pressure and intracranial pressure (ICP) were continuously measured. At 4 h after SDH rats were euthanized, brains sectioned, and immunoreacted with glia fibrillary acidic protein. Cortical infarct volume was quantified in coronal brain sections at 0.7-mm intervals from +1.0 mm to −3.9 mm relative to bregma. Infarct volume in drug-treated rats (
n=10) 22.1±6.99 mm
3 was significantly smaller (
p<0.02) than vehicle treated rats (
n=10) 56.7±9.59 mm
3. ICP, blood pressure and cerebral perfusion pressure were not significantly different between groups. These data suggest that activation of M1 muscarinic receptors during an ischemic event may contribute to the development of subsequent pathology.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>10661493</pmid><doi>10.1016/S0006-8993(99)02230-1</doi><tpages>8</tpages></addata></record> |
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| subjects | Acetylcholine Animals Biological and medical sciences Blood Pressure - drug effects Cerebral Infarction - etiology Cerebral Infarction - pathology Cerebral Infarction - physiopathology Cerebrovascular Circulation - drug effects Dicyclomine Dicyclomine - pharmacology Hematoma, Subdural - complications Injuries of the nervous system and the skull. Diseases due to physical agents Intracranial Pressure - drug effects Male Medical sciences Muscarinic Muscarinic Antagonists - pharmacology Rat Rats Rats, Sprague-Dawley Receptor Traumas. Diseases due to physical agents Traumatic brain injury |
| title | Dicyclomine, an M1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model |
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