Intracerebroventricular injection of agouti-related protein attenuates the anorexigenic effect of alpha-melanocyte stimulating hormone in neonatal chicks
It is well known that α-melanocyte stimulating hormone (α-MSH) inhibits feeding via melanocortin receptor-4 (MC4R) in the mammalian brain. The anorexigenic effect of α-MSH is attenuated by agouti-related protein (AGRP), an antagonist for MC4R. Present studies were carried out to clarify whether huma...
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| Veröffentlicht in: | Neuroscience letters 2001-06, Vol.305 (2), p.131-134 |
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| creator | Tachibana, Tetsuya Sugahara, Kunio Ohgushi, Atsushi Ando, Ryuichi Kawakami, Shin-Ichi Yoshimatsu, Takao Furuse, Mitsuhiro |
| description | It is well known that α-melanocyte stimulating hormone (α-MSH) inhibits feeding via melanocortin receptor-4 (MC4R) in the mammalian brain. The anorexigenic effect of α-MSH is attenuated by agouti-related protein (AGRP), an antagonist for MC4R. Present studies were carried out to clarify whether human AGRP (86–132) antagonizes the anorexigenic effect of α-MSH in broiler chicks. Intracerebroventricular injection of AGRP attenuated the anorexigenic effect of α-MSH. Furthermore, AGRP stimulated food intake of layer-type chicks under an ad libitum feeding condition but not broiler chicks, suggesting that the orexigenic effect of AGRP is different between two breeds. These also imply that the extent of the anorexigenic effect of endogenous α-MSH is different among two breeds. This may be a part of the difference in food intake between two breeds. |
| doi_str_mv | 10.1016/S0304-3940(01)01827-4 |
| format | Article |
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The anorexigenic effect of α-MSH is attenuated by agouti-related protein (AGRP), an antagonist for MC4R. Present studies were carried out to clarify whether human AGRP (86–132) antagonizes the anorexigenic effect of α-MSH in broiler chicks. Intracerebroventricular injection of AGRP attenuated the anorexigenic effect of α-MSH. Furthermore, AGRP stimulated food intake of layer-type chicks under an ad libitum feeding condition but not broiler chicks, suggesting that the orexigenic effect of AGRP is different between two breeds. These also imply that the extent of the anorexigenic effect of endogenous α-MSH is different among two breeds. This may be a part of the difference in food intake between two breeds.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(01)01827-4</identifier><identifier>PMID: 11376901</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Agouti-Related Protein ; alpha-MSH ; Animals ; Animals, Newborn - physiology ; Anorexia - chemically induced ; Anorexia - pathology ; Biological and medical sciences ; Broiler chick ; Chicken melanocortin receptor-4 ; Chickens - genetics ; Chickens - physiology ; Eating - drug effects ; Feeding ; Fundamental and applied biological sciences. Psychology ; Hormones and neuropeptides. Regulation ; Humans ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Injections, Intraventricular ; Layer-type chick ; Male ; Peptide Fragments - pharmacology ; Receptor, Melanocortin, Type 4 ; Receptors, Corticotropin - antagonists & inhibitors ; Species Specificity ; Vertebrates: endocrinology ; α-melanocyte stimulating hormone</subject><ispartof>Neuroscience letters, 2001-06, Vol.305 (2), p.131-134</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-eef6f7daf5efecda7ccfc033516269fc0d0244c50c2ad402ae9f48f5a30e2a263</citedby><cites>FETCH-LOGICAL-c455t-eef6f7daf5efecda7ccfc033516269fc0d0244c50c2ad402ae9f48f5a30e2a263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(01)01827-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=984603$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11376901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tachibana, Tetsuya</creatorcontrib><creatorcontrib>Sugahara, Kunio</creatorcontrib><creatorcontrib>Ohgushi, Atsushi</creatorcontrib><creatorcontrib>Ando, Ryuichi</creatorcontrib><creatorcontrib>Kawakami, Shin-Ichi</creatorcontrib><creatorcontrib>Yoshimatsu, Takao</creatorcontrib><creatorcontrib>Furuse, Mitsuhiro</creatorcontrib><title>Intracerebroventricular injection of agouti-related protein attenuates the anorexigenic effect of alpha-melanocyte stimulating hormone in neonatal chicks</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>It is well known that α-melanocyte stimulating hormone (α-MSH) inhibits feeding via melanocortin receptor-4 (MC4R) in the mammalian brain. The anorexigenic effect of α-MSH is attenuated by agouti-related protein (AGRP), an antagonist for MC4R. Present studies were carried out to clarify whether human AGRP (86–132) antagonizes the anorexigenic effect of α-MSH in broiler chicks. Intracerebroventricular injection of AGRP attenuated the anorexigenic effect of α-MSH. Furthermore, AGRP stimulated food intake of layer-type chicks under an ad libitum feeding condition but not broiler chicks, suggesting that the orexigenic effect of AGRP is different between two breeds. These also imply that the extent of the anorexigenic effect of endogenous α-MSH is different among two breeds. This may be a part of the difference in food intake between two breeds.</description><subject>Agouti-Related Protein</subject><subject>alpha-MSH</subject><subject>Animals</subject><subject>Animals, Newborn - physiology</subject><subject>Anorexia - chemically induced</subject><subject>Anorexia - pathology</subject><subject>Biological and medical sciences</subject><subject>Broiler chick</subject><subject>Chicken melanocortin receptor-4</subject><subject>Chickens - genetics</subject><subject>Chickens - physiology</subject><subject>Eating - drug effects</subject><subject>Feeding</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Humans</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Injections, Intraventricular</subject><subject>Layer-type chick</subject><subject>Male</subject><subject>Peptide Fragments - pharmacology</subject><subject>Receptor, Melanocortin, Type 4</subject><subject>Receptors, Corticotropin - antagonists & inhibitors</subject><subject>Species Specificity</subject><subject>Vertebrates: endocrinology</subject><subject>α-melanocyte stimulating hormone</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi1ERZeFRwBZQqrgEBgnTpycEKr4U6kSB-BsTZ3xrktiL7ZTtY_C29bdXZUjJ9uj3-dvZj7GXgl4L0B0H35AA7JqBglvQbwD0deqkk_YSvSqrtSg6qds9YicsucpXQNAK1r5jJ0K0ahuALFify98jmgo0lUMN1QeziwTRu78NZnsgufBctyEJbsq0oSZRr6LIZPzHHMmv5RS4nlLHH2IdOs25J3hZG3R78XTbovVXLQ-mLtMPGU3F4_s_IZvQ5yDp2LHPQWPGSduts78Ti_YicUp0cvjuWa_vnz-ef6tuvz-9eL802VlZNvmish2Vo1oWyqGIypjrIGmaUVXd0O5jlBLaVowNY4SaqTByt622ADVWHfNmp0d_i1T_VkoZT27ZGgq7VJYklbQ94NqoIDtATQxpBTJ6l10M8Y7LUA_ZKL3meiHhWsQep-JlkX3-miwXM00_lMdQyjAmyOAyeBkI3rj0iM39LIrA63ZxwNFZRk3jqJOxpE3NLpYNq3H4P7TyD2fea4f</recordid><startdate>20010608</startdate><enddate>20010608</enddate><creator>Tachibana, Tetsuya</creator><creator>Sugahara, Kunio</creator><creator>Ohgushi, Atsushi</creator><creator>Ando, Ryuichi</creator><creator>Kawakami, Shin-Ichi</creator><creator>Yoshimatsu, Takao</creator><creator>Furuse, Mitsuhiro</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010608</creationdate><title>Intracerebroventricular injection of agouti-related protein attenuates the anorexigenic effect of alpha-melanocyte stimulating hormone in neonatal chicks</title><author>Tachibana, Tetsuya ; Sugahara, Kunio ; Ohgushi, Atsushi ; Ando, Ryuichi ; Kawakami, Shin-Ichi ; Yoshimatsu, Takao ; Furuse, Mitsuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-eef6f7daf5efecda7ccfc033516269fc0d0244c50c2ad402ae9f48f5a30e2a263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Agouti-Related Protein</topic><topic>alpha-MSH</topic><topic>Animals</topic><topic>Animals, Newborn - physiology</topic><topic>Anorexia - chemically induced</topic><topic>Anorexia - pathology</topic><topic>Biological and medical sciences</topic><topic>Broiler chick</topic><topic>Chicken melanocortin receptor-4</topic><topic>Chickens - genetics</topic><topic>Chickens - physiology</topic><topic>Eating - drug effects</topic><topic>Feeding</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Humans</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Injections, Intraventricular</topic><topic>Layer-type chick</topic><topic>Male</topic><topic>Peptide Fragments - pharmacology</topic><topic>Receptor, Melanocortin, Type 4</topic><topic>Receptors, Corticotropin - antagonists & inhibitors</topic><topic>Species Specificity</topic><topic>Vertebrates: endocrinology</topic><topic>α-melanocyte stimulating hormone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tachibana, Tetsuya</creatorcontrib><creatorcontrib>Sugahara, Kunio</creatorcontrib><creatorcontrib>Ohgushi, Atsushi</creatorcontrib><creatorcontrib>Ando, Ryuichi</creatorcontrib><creatorcontrib>Kawakami, Shin-Ichi</creatorcontrib><creatorcontrib>Yoshimatsu, Takao</creatorcontrib><creatorcontrib>Furuse, Mitsuhiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tachibana, Tetsuya</au><au>Sugahara, Kunio</au><au>Ohgushi, Atsushi</au><au>Ando, Ryuichi</au><au>Kawakami, Shin-Ichi</au><au>Yoshimatsu, Takao</au><au>Furuse, Mitsuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracerebroventricular injection of agouti-related protein attenuates the anorexigenic effect of alpha-melanocyte stimulating hormone in neonatal chicks</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2001-06-08</date><risdate>2001</risdate><volume>305</volume><issue>2</issue><spage>131</spage><epage>134</epage><pages>131-134</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>It is well known that α-melanocyte stimulating hormone (α-MSH) inhibits feeding via melanocortin receptor-4 (MC4R) in the mammalian brain. The anorexigenic effect of α-MSH is attenuated by agouti-related protein (AGRP), an antagonist for MC4R. Present studies were carried out to clarify whether human AGRP (86–132) antagonizes the anorexigenic effect of α-MSH in broiler chicks. Intracerebroventricular injection of AGRP attenuated the anorexigenic effect of α-MSH. Furthermore, AGRP stimulated food intake of layer-type chicks under an ad libitum feeding condition but not broiler chicks, suggesting that the orexigenic effect of AGRP is different between two breeds. These also imply that the extent of the anorexigenic effect of endogenous α-MSH is different among two breeds. This may be a part of the difference in food intake between two breeds.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11376901</pmid><doi>10.1016/S0304-3940(01)01827-4</doi><tpages>4</tpages></addata></record> |
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| subjects | Agouti-Related Protein alpha-MSH Animals Animals, Newborn - physiology Anorexia - chemically induced Anorexia - pathology Biological and medical sciences Broiler chick Chicken melanocortin receptor-4 Chickens - genetics Chickens - physiology Eating - drug effects Feeding Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Humans Hypothalamus. Hypophysis. Epiphysis. Urophysis Injections, Intraventricular Layer-type chick Male Peptide Fragments - pharmacology Receptor, Melanocortin, Type 4 Receptors, Corticotropin - antagonists & inhibitors Species Specificity Vertebrates: endocrinology α-melanocyte stimulating hormone |
| title | Intracerebroventricular injection of agouti-related protein attenuates the anorexigenic effect of alpha-melanocyte stimulating hormone in neonatal chicks |
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