Characteristics of thyroid carcinomas in aging patients
Background To investigate the clinical features of thyroid cancer in aging patients and to present the results of treatment. From this we can provide bases for earlier diagnoses and better treatment of thyroid malignancies in older patients. Materials and methods In this study a retrospective analys...
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| Veröffentlicht in: | European journal of clinical investigation 2000-02, Vol.30 (2), p.147-153 |
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| creator | LIN, J. D CHAO, T. C CHEN, S. T WENG, H. F LIN, K. D |
| description | Background
To investigate the clinical features of thyroid cancer in aging patients and to present the results of treatment. From this we can provide bases for earlier diagnoses and better treatment of thyroid malignancies in older patients.
Materials and methods
In this study a retrospective analysis was performed with 204 thyroid cancer patients aged 60 years or older (132 women, with a mean age of 68.3 ± 6.6 years; 72 men, with a mean age of 67.0 ± 5.3 years).
Results
Of the 204 patients, 142 had well‐differentiated thyroid carcinomas (96 papillary thyroid carcinomas, 43 follicular carcinomas, three Hürthle cell carcinomas) and three medullary carcinomas. Sixty‐nine (33.8%) of the 204 patients died after treatment. Of these, three patients died of causes not related to thyroid cancer. For well‐differentiated thyroid carcinomas, male gender, follicular carcinoma, and a larger tumour size indicated a poor prognosis. Of the 59 non‐well‐differentiated thyroid carcinomas, 39 were anaplastic thyroid carcinomas, nine metastatic cancers of the thyroid, seven lymphomas, and four squamous cell carcinomas. After treatment, 40 (67.8%) of the 59 patients died. In multivariant analysis of the differences in clinical parameters between aging and younger thyroid cancer patients, the current status, tumour size, follow‐up period, sex, and stage at diagnosis were independent factors. From this data the delayed diagnosis of aging patients with thyroid cancer was of note when compared with younger patients.
Conclusion
Thyroid cancer in older patients is not a benign clinical disorder. Early diagnosis and urgent aggressive treatment are recommended courses of action for this type of cancer, especially for non‐well‐differentiated thyroid cancers. |
| doi_str_mv | 10.1046/j.1365-2362.2000.00598.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70889474</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>49992224</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5248-ceec960b2b4cf8e30e4f3ed1b627fbf3b9104a703c4780a92ade7b8f8b3efc8a3</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0EokvhL6AIIW4J44_EtsQFrdpSqbQHvo6W4x23XrLJYmfF7r-vQ1YFcerJI_l5Z8aPCSkoVBRE835dUd7UJeMNqxgAVAC1VtX-CVk8XDwlCwAqSqYlOyEvUlpnUFHOnpMTCk1NlYAFkcs7G60bMYY0BpeKwRfj3SEOYVU4G13oh41NRegLexv622Jrx4D9mF6SZ952CV8dz1Py7fzs6_JTeXVzcbn8eFW6mglVOkSnG2hZK5xXyAGF57iibcOkbz1vdX6PlcCdkAqsZnaFslVetRy9U5afkndz320cfu0wjWYTksOusz0Ou2QkKKWFFBl88x-4Hnaxz7sZqjWlTS0gQ2qGXBxSiujNNoaNjQdDwUxmzdpMAs0k0ExmzR-zZp-jr4_9d-0GV_8EZ5UZeHsEbHK289H2LqS_HKuprCfsw4z9Dh0eHj3fnC0vc5Hj5RzP34X7h7iNP00juazNj-sLo74I_p2ea_OZ3wOHa6Ii</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199116540</pqid></control><display><type>article</type><title>Characteristics of thyroid carcinomas in aging patients</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>LIN, J. D ; CHAO, T. C ; CHEN, S. T ; WENG, H. F ; LIN, K. D</creator><creatorcontrib>LIN, J. D ; CHAO, T. C ; CHEN, S. T ; WENG, H. F ; LIN, K. D</creatorcontrib><description>Background
To investigate the clinical features of thyroid cancer in aging patients and to present the results of treatment. From this we can provide bases for earlier diagnoses and better treatment of thyroid malignancies in older patients.
Materials and methods
In this study a retrospective analysis was performed with 204 thyroid cancer patients aged 60 years or older (132 women, with a mean age of 68.3 ± 6.6 years; 72 men, with a mean age of 67.0 ± 5.3 years).
Results
Of the 204 patients, 142 had well‐differentiated thyroid carcinomas (96 papillary thyroid carcinomas, 43 follicular carcinomas, three Hürthle cell carcinomas) and three medullary carcinomas. Sixty‐nine (33.8%) of the 204 patients died after treatment. Of these, three patients died of causes not related to thyroid cancer. For well‐differentiated thyroid carcinomas, male gender, follicular carcinoma, and a larger tumour size indicated a poor prognosis. Of the 59 non‐well‐differentiated thyroid carcinomas, 39 were anaplastic thyroid carcinomas, nine metastatic cancers of the thyroid, seven lymphomas, and four squamous cell carcinomas. After treatment, 40 (67.8%) of the 59 patients died. In multivariant analysis of the differences in clinical parameters between aging and younger thyroid cancer patients, the current status, tumour size, follow‐up period, sex, and stage at diagnosis were independent factors. From this data the delayed diagnosis of aging patients with thyroid cancer was of note when compared with younger patients.
Conclusion
Thyroid cancer in older patients is not a benign clinical disorder. Early diagnosis and urgent aggressive treatment are recommended courses of action for this type of cancer, especially for non‐well‐differentiated thyroid cancers.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1046/j.1365-2362.2000.00598.x</identifier><identifier>PMID: 10651840</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Science Ltd</publisher><subject>Adenocarcinoma, Follicular - mortality ; Adenocarcinoma, Follicular - pathology ; Adenocarcinoma, Follicular - therapy ; Aged ; Aged, 80 and over ; Aging - pathology ; Biological and medical sciences ; Carcinoma - mortality ; Carcinoma - pathology ; Carcinoma - therapy ; Carcinoma, Papillary - mortality ; Carcinoma, Papillary - pathology ; Carcinoma, Papillary - therapy ; Endocrinopathies ; Female ; Follicular thyroid carcinoma ; Humans ; Male ; Malignant tumors ; Medical sciences ; papillary thyroid carcinoma ; radioactive iodide ; thyroglobulin ; Thyroid Neoplasms - mortality ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - therapy ; Thyroid. Thyroid axis (diseases)</subject><ispartof>European journal of clinical investigation, 2000-02, Vol.30 (2), p.147-153</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Feb 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5248-ceec960b2b4cf8e30e4f3ed1b627fbf3b9104a703c4780a92ade7b8f8b3efc8a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2362.2000.00598.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2362.2000.00598.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1251750$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10651840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIN, J. D</creatorcontrib><creatorcontrib>CHAO, T. C</creatorcontrib><creatorcontrib>CHEN, S. T</creatorcontrib><creatorcontrib>WENG, H. F</creatorcontrib><creatorcontrib>LIN, K. D</creatorcontrib><title>Characteristics of thyroid carcinomas in aging patients</title><title>European journal of clinical investigation</title><addtitle>European Journal of Clinical Investigation</addtitle><description>Background
To investigate the clinical features of thyroid cancer in aging patients and to present the results of treatment. From this we can provide bases for earlier diagnoses and better treatment of thyroid malignancies in older patients.
Materials and methods
In this study a retrospective analysis was performed with 204 thyroid cancer patients aged 60 years or older (132 women, with a mean age of 68.3 ± 6.6 years; 72 men, with a mean age of 67.0 ± 5.3 years).
Results
Of the 204 patients, 142 had well‐differentiated thyroid carcinomas (96 papillary thyroid carcinomas, 43 follicular carcinomas, three Hürthle cell carcinomas) and three medullary carcinomas. Sixty‐nine (33.8%) of the 204 patients died after treatment. Of these, three patients died of causes not related to thyroid cancer. For well‐differentiated thyroid carcinomas, male gender, follicular carcinoma, and a larger tumour size indicated a poor prognosis. Of the 59 non‐well‐differentiated thyroid carcinomas, 39 were anaplastic thyroid carcinomas, nine metastatic cancers of the thyroid, seven lymphomas, and four squamous cell carcinomas. After treatment, 40 (67.8%) of the 59 patients died. In multivariant analysis of the differences in clinical parameters between aging and younger thyroid cancer patients, the current status, tumour size, follow‐up period, sex, and stage at diagnosis were independent factors. From this data the delayed diagnosis of aging patients with thyroid cancer was of note when compared with younger patients.
Conclusion
Thyroid cancer in older patients is not a benign clinical disorder. Early diagnosis and urgent aggressive treatment are recommended courses of action for this type of cancer, especially for non‐well‐differentiated thyroid cancers.</description><subject>Adenocarcinoma, Follicular - mortality</subject><subject>Adenocarcinoma, Follicular - pathology</subject><subject>Adenocarcinoma, Follicular - therapy</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - pathology</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - therapy</subject><subject>Carcinoma, Papillary - mortality</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Papillary - therapy</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Follicular thyroid carcinoma</subject><subject>Humans</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>papillary thyroid carcinoma</subject><subject>radioactive iodide</subject><subject>thyroglobulin</subject><subject>Thyroid Neoplasms - mortality</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - therapy</subject><subject>Thyroid. Thyroid axis (diseases)</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhL6AIIW4J44_EtsQFrdpSqbQHvo6W4x23XrLJYmfF7r-vQ1YFcerJI_l5Z8aPCSkoVBRE835dUd7UJeMNqxgAVAC1VtX-CVk8XDwlCwAqSqYlOyEvUlpnUFHOnpMTCk1NlYAFkcs7G60bMYY0BpeKwRfj3SEOYVU4G13oh41NRegLexv622Jrx4D9mF6SZ952CV8dz1Py7fzs6_JTeXVzcbn8eFW6mglVOkSnG2hZK5xXyAGF57iibcOkbz1vdX6PlcCdkAqsZnaFslVetRy9U5afkndz320cfu0wjWYTksOusz0Ou2QkKKWFFBl88x-4Hnaxz7sZqjWlTS0gQ2qGXBxSiujNNoaNjQdDwUxmzdpMAs0k0ExmzR-zZp-jr4_9d-0GV_8EZ5UZeHsEbHK289H2LqS_HKuprCfsw4z9Dh0eHj3fnC0vc5Hj5RzP34X7h7iNP00juazNj-sLo74I_p2ea_OZ3wOHa6Ii</recordid><startdate>200002</startdate><enddate>200002</enddate><creator>LIN, J. D</creator><creator>CHAO, T. C</creator><creator>CHEN, S. T</creator><creator>WENG, H. F</creator><creator>LIN, K. D</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200002</creationdate><title>Characteristics of thyroid carcinomas in aging patients</title><author>LIN, J. D ; CHAO, T. C ; CHEN, S. T ; WENG, H. F ; LIN, K. D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5248-ceec960b2b4cf8e30e4f3ed1b627fbf3b9104a703c4780a92ade7b8f8b3efc8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adenocarcinoma, Follicular - mortality</topic><topic>Adenocarcinoma, Follicular - pathology</topic><topic>Adenocarcinoma, Follicular - therapy</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - pathology</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - therapy</topic><topic>Carcinoma, Papillary - mortality</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Papillary - therapy</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Follicular thyroid carcinoma</topic><topic>Humans</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>papillary thyroid carcinoma</topic><topic>radioactive iodide</topic><topic>thyroglobulin</topic><topic>Thyroid Neoplasms - mortality</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - therapy</topic><topic>Thyroid. Thyroid axis (diseases)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIN, J. D</creatorcontrib><creatorcontrib>CHAO, T. C</creatorcontrib><creatorcontrib>CHEN, S. T</creatorcontrib><creatorcontrib>WENG, H. F</creatorcontrib><creatorcontrib>LIN, K. D</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIN, J. D</au><au>CHAO, T. C</au><au>CHEN, S. T</au><au>WENG, H. F</au><au>LIN, K. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of thyroid carcinomas in aging patients</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>European Journal of Clinical Investigation</addtitle><date>2000-02</date><risdate>2000</risdate><volume>30</volume><issue>2</issue><spage>147</spage><epage>153</epage><pages>147-153</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background
To investigate the clinical features of thyroid cancer in aging patients and to present the results of treatment. From this we can provide bases for earlier diagnoses and better treatment of thyroid malignancies in older patients.
Materials and methods
In this study a retrospective analysis was performed with 204 thyroid cancer patients aged 60 years or older (132 women, with a mean age of 68.3 ± 6.6 years; 72 men, with a mean age of 67.0 ± 5.3 years).
Results
Of the 204 patients, 142 had well‐differentiated thyroid carcinomas (96 papillary thyroid carcinomas, 43 follicular carcinomas, three Hürthle cell carcinomas) and three medullary carcinomas. Sixty‐nine (33.8%) of the 204 patients died after treatment. Of these, three patients died of causes not related to thyroid cancer. For well‐differentiated thyroid carcinomas, male gender, follicular carcinoma, and a larger tumour size indicated a poor prognosis. Of the 59 non‐well‐differentiated thyroid carcinomas, 39 were anaplastic thyroid carcinomas, nine metastatic cancers of the thyroid, seven lymphomas, and four squamous cell carcinomas. After treatment, 40 (67.8%) of the 59 patients died. In multivariant analysis of the differences in clinical parameters between aging and younger thyroid cancer patients, the current status, tumour size, follow‐up period, sex, and stage at diagnosis were independent factors. From this data the delayed diagnosis of aging patients with thyroid cancer was of note when compared with younger patients.
Conclusion
Thyroid cancer in older patients is not a benign clinical disorder. Early diagnosis and urgent aggressive treatment are recommended courses of action for this type of cancer, especially for non‐well‐differentiated thyroid cancers.</abstract><cop>Oxford BSL</cop><pub>Blackwell Science Ltd</pub><pmid>10651840</pmid><doi>10.1046/j.1365-2362.2000.00598.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenocarcinoma, Follicular - mortality Adenocarcinoma, Follicular - pathology Adenocarcinoma, Follicular - therapy Aged Aged, 80 and over Aging - pathology Biological and medical sciences Carcinoma - mortality Carcinoma - pathology Carcinoma - therapy Carcinoma, Papillary - mortality Carcinoma, Papillary - pathology Carcinoma, Papillary - therapy Endocrinopathies Female Follicular thyroid carcinoma Humans Male Malignant tumors Medical sciences papillary thyroid carcinoma radioactive iodide thyroglobulin Thyroid Neoplasms - mortality Thyroid Neoplasms - pathology Thyroid Neoplasms - therapy Thyroid. Thyroid axis (diseases) |
| title | Characteristics of thyroid carcinomas in aging patients |
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