Model Systems for Flavoenzyme Activity. Control of Flavin Recognition via Specific Electrostatic Interactions

Model Systems for Flavoenzyme Activity. Control of Flavin Recognition via Specific Electrostatic Interactions

A model system has been used to study the interactions of dipole-containing aromatic systems with oxidized and reduced flavin. Ab initio computational and experimental studies show that dipole orientation within the host is a critical determinant for recognition and redox behavior of the flavin gues...

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Veröffentlicht in:Organic letters 2001-05, Vol.3 (10), p.1531-1534
Hauptverfasser: Goodman, Allan J, Breinlinger, Eric C, McIntosh, Catherine M, Grimaldi, Lisa N, Rotello, Vincent M
Format: Artikel
Sprache:eng
Schlagworte:
Dimerization
Flavins - metabolism
Models, Molecular
Oxidation-Reduction
Oxidoreductases - metabolism
Protein Binding
Static Electricity
Thermodynamics
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container_end_page 1534
container_issue 10
container_start_page 1531
container_title Organic letters
container_volume 3
creator Goodman, Allan J
Breinlinger, Eric C
McIntosh, Catherine M
Grimaldi, Lisa N
Rotello, Vincent M
description A model system has been used to study the interactions of dipole-containing aromatic systems with oxidized and reduced flavin. Ab initio computational and experimental studies show that dipole orientation within the host is a critical determinant for recognition and redox behavior of the flavin guest.
doi_str_mv 10.1021/ol015838l
format Article
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source MEDLINE; ACS Publications
subjects Dimerization
Flavins - metabolism
Models, Molecular
Oxidation-Reduction
Oxidoreductases - metabolism
Protein Binding
Static Electricity
Thermodynamics
title Model Systems for Flavoenzyme Activity. Control of Flavin Recognition via Specific Electrostatic Interactions
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