Levels and molecular properties of secretoneurin-immunoreactivity in the serum and urine of control and neuroendocrine tumor patients
We have determined the levels of secretoneurin (SN), a novel 33-amino acid neuropeptide belonging to the class of chromogranins, in the serum and urine of healthy subjects and patients suffering from various tumors. SN serum levels averaged 22.1+/-1.1 fmol/mL. They were 5-fold higher in younger chil...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2000, Vol.85 (1), p.355-360 |
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| creator | ISCHIA, R GASSER, R. W FISCHER-COLBRIE, R EDER, U PAGANI, A CUBEDDU, L. X LOVISETTI-SCAMIHORN, P FINKENSTEDT, G LASLOP, A WINKLER, H |
| description | We have determined the levels of secretoneurin (SN), a novel 33-amino acid neuropeptide belonging to the class of chromogranins, in the serum and urine of healthy subjects and patients suffering from various tumors. SN serum levels averaged 22.1+/-1.1 fmol/mL. They were 5-fold higher in younger children and then declined continuously. SN levels were positively correlated with serum creatinine, suggesting an influence of renal function on the clearance of SN from the serum. In the urine 80.0 fmol/mL SN was present. In patients with endocrine tumors like gut carcinoids, endocrine pancreatic tumors, oat cell lung carcinomas, and pheochromocytomas, SN serum levels were elevated up to 45-fold. Patients suffering from neuroblastomas, insulinomas, pituitary adenomas including acromegaly, and solid nonendocrine tumors had concentrations in the normal range. In human serum, SN-immunoreactivity was confined to the free peptide SN; neither larger intermediate-sized forms nor the precursor secretogranin II were detected. An efficient removal of the small molecule SN from the serum by the kidney explains why SN serum levels are lower when compared to chromogranin A, which is present as large molecule in serum. |
| doi_str_mv | 10.1210/jc.85.1.355 |
| format | Article |
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W ; FISCHER-COLBRIE, R ; EDER, U ; PAGANI, A ; CUBEDDU, L. X ; LOVISETTI-SCAMIHORN, P ; FINKENSTEDT, G ; LASLOP, A ; WINKLER, H</creator><creatorcontrib>ISCHIA, R ; GASSER, R. W ; FISCHER-COLBRIE, R ; EDER, U ; PAGANI, A ; CUBEDDU, L. X ; LOVISETTI-SCAMIHORN, P ; FINKENSTEDT, G ; LASLOP, A ; WINKLER, H</creatorcontrib><description>We have determined the levels of secretoneurin (SN), a novel 33-amino acid neuropeptide belonging to the class of chromogranins, in the serum and urine of healthy subjects and patients suffering from various tumors. SN serum levels averaged 22.1+/-1.1 fmol/mL. They were 5-fold higher in younger children and then declined continuously. SN levels were positively correlated with serum creatinine, suggesting an influence of renal function on the clearance of SN from the serum. In the urine 80.0 fmol/mL SN was present. In patients with endocrine tumors like gut carcinoids, endocrine pancreatic tumors, oat cell lung carcinomas, and pheochromocytomas, SN serum levels were elevated up to 45-fold. Patients suffering from neuroblastomas, insulinomas, pituitary adenomas including acromegaly, and solid nonendocrine tumors had concentrations in the normal range. In human serum, SN-immunoreactivity was confined to the free peptide SN; neither larger intermediate-sized forms nor the precursor secretogranin II were detected. An efficient removal of the small molecule SN from the serum by the kidney explains why SN serum levels are lower when compared to chromogranin A, which is present as large molecule in serum.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.85.1.355</identifier><identifier>PMID: 10634410</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adolescent ; Aging - metabolism ; Biological and medical sciences ; Biomarkers, Tumor ; Child ; Child, Preschool ; Chromatography, Ion Exchange ; Creatinine - blood ; Female ; Glucose Tolerance Test ; Host-tumor relations. Immunology. Biological markers ; Humans ; Infant ; Male ; Medical sciences ; Neuroendocrine Tumors - blood ; Neuroendocrine Tumors - metabolism ; Neuroendocrine Tumors - urine ; Neuropeptides - chemistry ; Neuropeptides - metabolism ; Radioimmunoassay ; Reference Values ; Secretogranin II ; Tumors</subject><ispartof>The journal of clinical endocrinology and metabolism, 2000, Vol.85 (1), p.355-360</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-4597c191c40b19aff95e7d6ef99289798fde564505dc19dc9cd6e556e8f174c33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1227864$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10634410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ISCHIA, R</creatorcontrib><creatorcontrib>GASSER, R. W</creatorcontrib><creatorcontrib>FISCHER-COLBRIE, R</creatorcontrib><creatorcontrib>EDER, U</creatorcontrib><creatorcontrib>PAGANI, A</creatorcontrib><creatorcontrib>CUBEDDU, L. X</creatorcontrib><creatorcontrib>LOVISETTI-SCAMIHORN, P</creatorcontrib><creatorcontrib>FINKENSTEDT, G</creatorcontrib><creatorcontrib>LASLOP, A</creatorcontrib><creatorcontrib>WINKLER, H</creatorcontrib><title>Levels and molecular properties of secretoneurin-immunoreactivity in the serum and urine of control and neuroendocrine tumor patients</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>We have determined the levels of secretoneurin (SN), a novel 33-amino acid neuropeptide belonging to the class of chromogranins, in the serum and urine of healthy subjects and patients suffering from various tumors. SN serum levels averaged 22.1+/-1.1 fmol/mL. They were 5-fold higher in younger children and then declined continuously. SN levels were positively correlated with serum creatinine, suggesting an influence of renal function on the clearance of SN from the serum. In the urine 80.0 fmol/mL SN was present. In patients with endocrine tumors like gut carcinoids, endocrine pancreatic tumors, oat cell lung carcinomas, and pheochromocytomas, SN serum levels were elevated up to 45-fold. Patients suffering from neuroblastomas, insulinomas, pituitary adenomas including acromegaly, and solid nonendocrine tumors had concentrations in the normal range. In human serum, SN-immunoreactivity was confined to the free peptide SN; neither larger intermediate-sized forms nor the precursor secretogranin II were detected. An efficient removal of the small molecule SN from the serum by the kidney explains why SN serum levels are lower when compared to chromogranin A, which is present as large molecule in serum.</description><subject>Adolescent</subject><subject>Aging - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromatography, Ion Exchange</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Host-tumor relations. Immunology. Biological markers</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuroendocrine Tumors - blood</subject><subject>Neuroendocrine Tumors - metabolism</subject><subject>Neuroendocrine Tumors - urine</subject><subject>Neuropeptides - chemistry</subject><subject>Neuropeptides - metabolism</subject><subject>Radioimmunoassay</subject><subject>Reference Values</subject><subject>Secretogranin II</subject><subject>Tumors</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0E2LFDEQBuAgiju7evIufRAvS4-p7qTTOcriFwx4UfAWstUVzNCdjEl6YX_A_m8zH6CnQOqpKupl7A3wLXTAP-xxO8otbHspn7ENaCFbBVo9ZxvOO2i16n5dseuc95yDELJ_ya6AD70QwDfsaUcPNOfGhqlZ4ky4zjY1hxQPlIqn3ETXZMJEJQZakw-tX5Y1xEQWi3_w5bHxoSm_qaq0Lqc5R0bHRoyhpDifPo_dkcIU8VQt6xLrHlt3hJJfsRfOzpleX94b9vPzpx93X9vd9y_f7j7uWuxhKK2QWiFoQMHvQVvntCQ1DeS07kat9OgmkoOQXE6VTaixFqUcaHSgBPb9DXt_nlsP_LNSLmbxGWmebaC4ZqP4OOoeVIW3Z4gp5pzImUPyi02PBrg5pm72aEZpwNTUq357GbveLzT9Z88xV_DuAmxGO7tkA_r8z3WdGgfR_wVImI23</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>ISCHIA, R</creator><creator>GASSER, R. 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X ; LOVISETTI-SCAMIHORN, P ; FINKENSTEDT, G ; LASLOP, A ; WINKLER, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-4597c191c40b19aff95e7d6ef99289798fde564505dc19dc9cd6e556e8f174c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Aging - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromatography, Ion Exchange</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Host-tumor relations. Immunology. Biological markers</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuroendocrine Tumors - blood</topic><topic>Neuroendocrine Tumors - metabolism</topic><topic>Neuroendocrine Tumors - urine</topic><topic>Neuropeptides - chemistry</topic><topic>Neuropeptides - metabolism</topic><topic>Radioimmunoassay</topic><topic>Reference Values</topic><topic>Secretogranin II</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ISCHIA, R</creatorcontrib><creatorcontrib>GASSER, R. W</creatorcontrib><creatorcontrib>FISCHER-COLBRIE, R</creatorcontrib><creatorcontrib>EDER, U</creatorcontrib><creatorcontrib>PAGANI, A</creatorcontrib><creatorcontrib>CUBEDDU, L. X</creatorcontrib><creatorcontrib>LOVISETTI-SCAMIHORN, P</creatorcontrib><creatorcontrib>FINKENSTEDT, G</creatorcontrib><creatorcontrib>LASLOP, A</creatorcontrib><creatorcontrib>WINKLER, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ISCHIA, R</au><au>GASSER, R. W</au><au>FISCHER-COLBRIE, R</au><au>EDER, U</au><au>PAGANI, A</au><au>CUBEDDU, L. X</au><au>LOVISETTI-SCAMIHORN, P</au><au>FINKENSTEDT, G</au><au>LASLOP, A</au><au>WINKLER, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Levels and molecular properties of secretoneurin-immunoreactivity in the serum and urine of control and neuroendocrine tumor patients</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2000</date><risdate>2000</risdate><volume>85</volume><issue>1</issue><spage>355</spage><epage>360</epage><pages>355-360</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>We have determined the levels of secretoneurin (SN), a novel 33-amino acid neuropeptide belonging to the class of chromogranins, in the serum and urine of healthy subjects and patients suffering from various tumors. SN serum levels averaged 22.1+/-1.1 fmol/mL. They were 5-fold higher in younger children and then declined continuously. SN levels were positively correlated with serum creatinine, suggesting an influence of renal function on the clearance of SN from the serum. In the urine 80.0 fmol/mL SN was present. In patients with endocrine tumors like gut carcinoids, endocrine pancreatic tumors, oat cell lung carcinomas, and pheochromocytomas, SN serum levels were elevated up to 45-fold. Patients suffering from neuroblastomas, insulinomas, pituitary adenomas including acromegaly, and solid nonendocrine tumors had concentrations in the normal range. In human serum, SN-immunoreactivity was confined to the free peptide SN; neither larger intermediate-sized forms nor the precursor secretogranin II were detected. An efficient removal of the small molecule SN from the serum by the kidney explains why SN serum levels are lower when compared to chromogranin A, which is present as large molecule in serum.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>10634410</pmid><doi>10.1210/jc.85.1.355</doi><tpages>6</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Aging - metabolism Biological and medical sciences Biomarkers, Tumor Child Child, Preschool Chromatography, Ion Exchange Creatinine - blood Female Glucose Tolerance Test Host-tumor relations. Immunology. Biological markers Humans Infant Male Medical sciences Neuroendocrine Tumors - blood Neuroendocrine Tumors - metabolism Neuroendocrine Tumors - urine Neuropeptides - chemistry Neuropeptides - metabolism Radioimmunoassay Reference Values Secretogranin II Tumors |
| title | Levels and molecular properties of secretoneurin-immunoreactivity in the serum and urine of control and neuroendocrine tumor patients |
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