Loss of p16/CDKN2A tumor suppressor protein in gastric adenocarcinoma is associated with epstein-barr virus and anatomic location in the body of the stomach

Gastric adenocarcinomas (n = 125) were analyzed by immunohistochemistry for the presence of p16, the CDKN2A gene product. This protein was lost in 31 of 125 cases (25%), and loss was associated with location of the tumor in the body of the stomach ( P = .001). Loss of p16 was also associated with th...

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Veröffentlicht in:	Human pathology 2000, Vol.31 (1), p.45-50
Hauptverfasser:	Schneider, Barbara G., Gulley, Margaret L., Eagan, Phyllis, Bravo, Juan Carlos, Mera, Robertino, Geradts, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - virology African American Biological and medical sciences Cyclin-Dependent Kinase Inhibitor p16 - metabolism ethnicity Gastroenterology. Liver. Pancreas. Abdomen Herpesvirus 4, Human - isolation & purification Hispanic Humans Immunohistochemistry In Situ Hybridization Medical sciences microsatellite instability RNA, Viral - metabolism Stomach - pathology Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach Neoplasms - virology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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