Anti-HBs after hepatitis B immunization with plasma-derived and recombinant DNA-derived vaccines: binding to mutant HBsAg

The G145R mutant of the small S-protein is a major escape mutant of hepatitis B virus observed in natural infection, after immunization and HBIG therapy. In a previous study we found that plasma-derived and recombinant DNA-derived vaccine HBsAg reacted differently with monoclonal antibodies sensitiv...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2001-06, Vol.19 (27), p.3671-3680
Hauptverfasser:	Heijtink, R.A, van Bergen, P, van Roosmalen, M.H, Sünnen, C.M.G, Paulij, W.P, Schalm, S.W, Osterhaus, A.D.M.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution - immunology Anti-HBs Antibodies, Monoclonal - metabolism Binding Sites, Antibody Binding, Competitive - immunology Biological and medical sciences Characterization Epidemiology. Vaccinations Fundamental and applied biological sciences. Psychology General aspects Hepatitis B Antibodies - biosynthesis Hepatitis B Antibodies - metabolism hepatitis B surface antigen Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - metabolism Hepatitis B Vaccines - immunology hepatitis B virus Hepatitis B virus - immunology Humans Immunization Schedule Infectious diseases Medical sciences Microbiology Mutant Mutation Peptide Recombinant HBsAg Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - administration & dosage Vaccines, DNA - immunology Virology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!