Serum prolactin is associated with apoptosis in men with human immunodeficiency virus infection
We examined the in vivo and in vitro production of prolactin (PRL) in 20 untreated HIV‐infected men compared to 14 uninfected men and its association with the cell cycle and apoptosis. Compared to uninfected men, the HIV‐infected men had: (i) higher fasting serum bioactive (BIO) PRL; (ii) lower seru...
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| Veröffentlicht in: | Immunology and cell biology 2001-06, Vol.79 (3), p.285-290 |
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| creator | Parra, A Ramírez‐Peredo, J Larrea, F Pérez‐Romano, B Cabrera, V Torres, I Reyes‐Núñez, V Ruiz‐Argüelles, G Ruiz‐Argüelles, A |
| description | We examined the in vivo and in vitro production of prolactin (PRL) in 20 untreated HIV‐infected men compared to 14 uninfected men and its association with the cell cycle and apoptosis. Compared to uninfected men, the HIV‐infected men had: (i) higher fasting serum bioactive (BIO) PRL; (ii) lower serum immunoreactive (RIA) and BIO‐PRL responses to intravenous metoclopramide; (iii) greater BIO‐RIA PRL ratio both fasting and during intravenous metoclopramide; (iv) lower percentage of non‐stimulated PBMC in the G0/G1 phase, but a higher percentage in the S phase, of the cell cycle with normal response to Concanavalin‐A; and (v) higher in vitro production of BIO‐PRL by non‐stimulated PBMC, which was blocked after Concanavalin‐A. Fasting serum BIO‐PRL positively correlated with the percent of non‐stimulated PBMC in S + G2/M phases. The percentage of apoptotic PBMC negatively correlated with CD4+ T lymphocytes and with the area under the serum RIA–PRL curve, but positively correlated with the area under the curve for the BIO/RIA ratio. These results suggest that in these HIV‐infected men: (i) a diminished dopaminergic tone may exist, as an adaptive mechanism attempting to survive; and (ii) BIO‐PRL may participate as a cofactor in the stimulation of T‐cell proliferation. |
| doi_str_mv | 10.1046/j.1440-1711.2001.01012.x |
| format | Article |
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Compared to uninfected men, the HIV‐infected men had: (i) higher fasting serum bioactive (BIO) PRL; (ii) lower serum immunoreactive (RIA) and BIO‐PRL responses to intravenous metoclopramide; (iii) greater BIO‐RIA PRL ratio both fasting and during intravenous metoclopramide; (iv) lower percentage of non‐stimulated PBMC in the G0/G1 phase, but a higher percentage in the S phase, of the cell cycle with normal response to Concanavalin‐A; and (v) higher in vitro production of BIO‐PRL by non‐stimulated PBMC, which was blocked after Concanavalin‐A. Fasting serum BIO‐PRL positively correlated with the percent of non‐stimulated PBMC in S + G2/M phases. The percentage of apoptotic PBMC negatively correlated with CD4+ T lymphocytes and with the area under the serum RIA–PRL curve, but positively correlated with the area under the curve for the BIO/RIA ratio. These results suggest that in these HIV‐infected men: (i) a diminished dopaminergic tone may exist, as an adaptive mechanism attempting to survive; and (ii) BIO‐PRL may participate as a cofactor in the stimulation of T‐cell proliferation.</description><identifier>ISSN: 0818-9641</identifier><identifier>EISSN: 1440-1711</identifier><identifier>DOI: 10.1046/j.1440-1711.2001.01012.x</identifier><identifier>PMID: 11380682</identifier><language>eng</language><publisher>United States: Nature Publishing Group</publisher><subject>Adult ; Animals ; Apoptosis ; Area Under Curve ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes - physiology ; Cell Cycle ; Cells, Cultured ; concanavalin A ; Dopamine Antagonists - pharmacology ; HIV - metabolism ; HIV infection ; HIV Infections - blood ; HIV Infections - physiopathology ; Human immunodeficiency virus ; Humans ; in vitro prolactin ; Leukocytes, Mononuclear - metabolism ; Leukocytes, Mononuclear - physiology ; Male ; men ; Metoclopramide - pharmacology ; prolactin ; Prolactin - blood ; Radioimmunoassay ; serum prolactin ; Statistics as Topic</subject><ispartof>Immunology and cell biology, 2001-06, Vol.79 (3), p.285-290</ispartof><rights>2001 Australasian Society for Immunology Inc.</rights><rights>Copyright Nature Publishing Group Jun 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4511-359d1713fcf1980af73253decd636f4627c829a09d331a028703614fc1768c53</citedby><cites>FETCH-LOGICAL-c4511-359d1713fcf1980af73253decd636f4627c829a09d331a028703614fc1768c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1440-1711.2001.01012.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1440-1711.2001.01012.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11380682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parra, A</creatorcontrib><creatorcontrib>Ramírez‐Peredo, J</creatorcontrib><creatorcontrib>Larrea, F</creatorcontrib><creatorcontrib>Pérez‐Romano, B</creatorcontrib><creatorcontrib>Cabrera, V</creatorcontrib><creatorcontrib>Torres, I</creatorcontrib><creatorcontrib>Reyes‐Núñez, V</creatorcontrib><creatorcontrib>Ruiz‐Argüelles, G</creatorcontrib><creatorcontrib>Ruiz‐Argüelles, A</creatorcontrib><title>Serum prolactin is associated with apoptosis in men with human immunodeficiency virus infection</title><title>Immunology and cell biology</title><addtitle>Immunol Cell Biol</addtitle><description>We examined the in vivo and in vitro production of prolactin (PRL) in 20 untreated HIV‐infected men compared to 14 uninfected men and its association with the cell cycle and apoptosis. Compared to uninfected men, the HIV‐infected men had: (i) higher fasting serum bioactive (BIO) PRL; (ii) lower serum immunoreactive (RIA) and BIO‐PRL responses to intravenous metoclopramide; (iii) greater BIO‐RIA PRL ratio both fasting and during intravenous metoclopramide; (iv) lower percentage of non‐stimulated PBMC in the G0/G1 phase, but a higher percentage in the S phase, of the cell cycle with normal response to Concanavalin‐A; and (v) higher in vitro production of BIO‐PRL by non‐stimulated PBMC, which was blocked after Concanavalin‐A. Fasting serum BIO‐PRL positively correlated with the percent of non‐stimulated PBMC in S + G2/M phases. The percentage of apoptotic PBMC negatively correlated with CD4+ T lymphocytes and with the area under the serum RIA–PRL curve, but positively correlated with the area under the curve for the BIO/RIA ratio. These results suggest that in these HIV‐infected men: (i) a diminished dopaminergic tone may exist, as an adaptive mechanism attempting to survive; and (ii) BIO‐PRL may participate as a cofactor in the stimulation of T‐cell proliferation.</description><subject>Adult</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Area Under Curve</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4-Positive T-Lymphocytes - physiology</subject><subject>Cell Cycle</subject><subject>Cells, Cultured</subject><subject>concanavalin A</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>HIV - metabolism</subject><subject>HIV infection</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - physiopathology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>in vitro prolactin</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Leukocytes, Mononuclear - physiology</subject><subject>Male</subject><subject>men</subject><subject>Metoclopramide - pharmacology</subject><subject>prolactin</subject><subject>Prolactin - blood</subject><subject>Radioimmunoassay</subject><subject>serum prolactin</subject><subject>Statistics as Topic</subject><issn>0818-9641</issn><issn>1440-1711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUFv1DAQhS0EotvCX4BISNySztiJ7dyAFZRKRT20d8t1HNWrJF7shHb_PTZZFYkLPVma-eY9Pz1CCoQKoebnuwrrGkoUiBUFwAoQkFaPL8jmafGSbECiLFte4wk5jXEHAIJK9pqcIDIJXNINUTc2LGOxD37QZnZT4WKhY_TG6dl2xYOb7wu99_vZx7RJ-9FO6_R-GXXCx3GZfGd7Z5ydzKH45cKSwd4mOT-9Ia96PUT79viekdtvX2-338ur64vL7eer0tQNYsmatkufZr3psZWge8FowzprOs54X3MqjKSthrZjDDVQKYBxrHuDgkvTsDPycZVNQX4uNs5qdNHYYdCT9UtUAqTk2eB_IEpklAuawA__gDu_hCllUCgkl1A3IvvKlTLBxxhsr_bBjTocFILKVamdyo2o3IjKVak_VanHdPruaLDcjbb7e3jsJgGfVuDBDfbwbGF1-WP7JQ_qnPb9KjHpeQn2ScOZuyPxG9eUrFw</recordid><startdate>200106</startdate><enddate>200106</enddate><creator>Parra, A</creator><creator>Ramírez‐Peredo, J</creator><creator>Larrea, F</creator><creator>Pérez‐Romano, B</creator><creator>Cabrera, V</creator><creator>Torres, I</creator><creator>Reyes‐Núñez, V</creator><creator>Ruiz‐Argüelles, G</creator><creator>Ruiz‐Argüelles, A</creator><general>Nature Publishing Group</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200106</creationdate><title>Serum prolactin is associated with apoptosis in men with human immunodeficiency virus infection</title><author>Parra, A ; 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Compared to uninfected men, the HIV‐infected men had: (i) higher fasting serum bioactive (BIO) PRL; (ii) lower serum immunoreactive (RIA) and BIO‐PRL responses to intravenous metoclopramide; (iii) greater BIO‐RIA PRL ratio both fasting and during intravenous metoclopramide; (iv) lower percentage of non‐stimulated PBMC in the G0/G1 phase, but a higher percentage in the S phase, of the cell cycle with normal response to Concanavalin‐A; and (v) higher in vitro production of BIO‐PRL by non‐stimulated PBMC, which was blocked after Concanavalin‐A. Fasting serum BIO‐PRL positively correlated with the percent of non‐stimulated PBMC in S + G2/M phases. The percentage of apoptotic PBMC negatively correlated with CD4+ T lymphocytes and with the area under the serum RIA–PRL curve, but positively correlated with the area under the curve for the BIO/RIA ratio. These results suggest that in these HIV‐infected men: (i) a diminished dopaminergic tone may exist, as an adaptive mechanism attempting to survive; and (ii) BIO‐PRL may participate as a cofactor in the stimulation of T‐cell proliferation.</abstract><cop>United States</cop><pub>Nature Publishing Group</pub><pmid>11380682</pmid><doi>10.1046/j.1440-1711.2001.01012.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Animals Apoptosis Area Under Curve CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - physiology Cell Cycle Cells, Cultured concanavalin A Dopamine Antagonists - pharmacology HIV - metabolism HIV infection HIV Infections - blood HIV Infections - physiopathology Human immunodeficiency virus Humans in vitro prolactin Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - physiology Male men Metoclopramide - pharmacology prolactin Prolactin - blood Radioimmunoassay serum prolactin Statistics as Topic |
| title | Serum prolactin is associated with apoptosis in men with human immunodeficiency virus infection |
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