Effects of sildenafil on cAMP and cGMP levels in isolated human cavernous and cardiac tissue

Objectives. To further investigate the mechanism of action of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase 5 (PDE5), that has been proved to be effective in the treatment of male erectile dysfunction. We assessed the effects of sildenafil on t...

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Veröffentlicht in:	Urology (Ridgewood, N.J.) N.J.), 2000, Vol.55 (1), p.146-150
Hauptverfasser:	Stief, Christian G, Ückert, Stefan, Becker, Armin J, Harringer, Wolfgang, Truss, Michael C, Forssmann, Wolf-Georg, Jonas, Udo
Format:	Artikel
Sprache:	eng
Schlagworte:	Colforsin - pharmacology Cyclic AMP - biosynthesis Cyclic GMP - biosynthesis Heart - drug effects Humans In Vitro Techniques Male Milrinone - pharmacology Myocardium - metabolism Penis - drug effects Penis - metabolism Phosphodiesterase Inhibitors - pharmacology Piperazines - pharmacology Purines Sildenafil Citrate Sulfones
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