In vitro metabolism of 19-nor-1alpha, 25-(OH)2D2 in cultured cell lines: inducible synthesis of lipid- and water-soluble metabolites

The active vitamin D analog, 19-nor-1alpha,25-dihydroxyvitamin D2 (19-nor-1alpha,25-(OH)2D2), has a similar structure to the natural vitamin D hormone, 1a,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3), but lacks the C10-19 methylene group and possesses an ergosterol/ vitamin D2 rather than a cholestero...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2001-03, Vol.387 (2), p.297-306
Hauptverfasser:	Shankar, V N, Propp, A E, Schroeder, N, Surber, B W, Makin, H L, Jones, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - chemistry Carcinoma, Hepatocellular - metabolism Cell Line Chromatography, High Pressure Liquid Ergocalciferols - analysis Ergocalciferols - metabolism Gas Chromatography-Mass Spectrometry Humans Keratinocytes - chemistry Keratinocytes - cytology Keratinocytes - metabolism Lipids - chemistry Molecular Structure Silanes Solubility Trimethylsilyl Compounds Vitamin D - analogs & derivatives Vitamin D - analysis Vitamin D - biosynthesis
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