Nociceptin inhibits the neurogenic vasopressor response in the pithed rat via prejunctional ORL1 receptors

Nociceptin (or orphanin FQ), the endogenous ligand for the opioid receptor-like 1 (ORL1) receptor, decreases blood pressure in the conscious and anesthetized rat. This study examined whether prejunctional inhibitory ORL1 receptors located on the postganglionic sympathetic neurons innervating the res...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2000-01, Vol.361 (1), p.80-84
Hauptverfasser:	Malinowska, B, Kozłowska, H, Koneczny, B, Schlicker, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autonomic Fibers, Preganglionic - drug effects Blood Pressure - drug effects Decerebrate State - physiopathology Electric Stimulation In Vitro Techniques Male Naloxone - pharmacology Narcotic Antagonists - pharmacology Nervous System Physiological Phenomena - drug effects Neuromuscular Junction - drug effects Nicotine - pharmacology Nicotinic Agonists - pharmacology Nociceptin Nociceptin Receptor Norepinephrine - pharmacology Opioid Peptides - pharmacology Rats Rats, Wistar Receptors, Opioid - agonists Sympathomimetics - pharmacology Vagotomy
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