Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair

The activated insulin-like growth factor-I receptor (IGF-IR) is implicated in mitogenesis, transformation, and anti-apoptosis. To investigate the role of the IGF-IR in protection from UV-mimetic-induced DNA damage, 4-nitroquinoline N-oxide (4-NQO) was used. In this study we show that the activation...

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Veröffentlicht in:The Journal of biological chemistry 2001-05, Vol.276 (21), p.18185-18192
Hauptverfasser: Héron-Milhavet, L, Karas, M, Goldsmith, C M, Baum, B J, LeRoith, D
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Sprache:eng
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