Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity

The bifunctional enzyme aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) is responsible for catalysis of the last two steps in the de novo purine pathway. Gel filtration studies performed on human enzyme suggested that this enzyme is monomeric in s...

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Veröffentlicht in:	The Journal of biological chemistry 2001-03, Vol.276 (11), p.7727-7733
Hauptverfasser:	Vergis, J M, Bulock, K G, Fleming, K G, Beardsley, G P
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aminoimidazole-4-carboxamide ribonucleotide transformylase Dimerization Humans Hydroxymethyl and Formyl Transferases - chemistry Hydroxymethyl and Formyl Transferases - metabolism inosine monophosphate cyclohydrolase Kinetics Multienzyme Complexes - chemistry Multienzyme Complexes - metabolism Nucleotide Deaminases - chemistry Nucleotide Deaminases - metabolism purines
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