The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans

We have molecularly characterized the lin-49 and lin-59 genes in C. elegans, and found their products are related to Drosophila trithorax group (trx-G) proteins and other proteins implicated in chromatin remodelling. LIN-49 is structurally most similar to the human bromodomain protein BR140, and LIN...

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Veröffentlicht in:	Development (Cambridge) 2000-02, Vol.127 (4), p.713-723
Hauptverfasser:	Chamberlin, H M, Thomas, J H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Animals, Genetically Modified ASH1 protein BR140 protein Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins Chromatin - genetics DNA-Binding Proteins - genetics Drosophila - genetics Drosophila Proteins egl-5 gene Female Gene Expression Regulation, Developmental Genes, Helminth Genes, Insect Helminth Proteins - genetics Helminth Proteins - physiology HOM-C gene Humans Insect Proteins - genetics lin-49 gene lin-59 gene LIN-59 protein mab-5 gene Male mes-2 gene mes-6 gene Molecular Sequence Data Mutation Nuclear Proteins - genetics Phenotype Species Specificity Tail - growth & development Transcription Factors trithorax group protein
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