Lack of Lymphangiogenesis Despite Coexpression of VEGF-C and Its Receptor Flt-4 in Uveal Melanoma

Because lymphatic vessels are absent from the normal eye and because uveal melanomas are presumed to spread by a hematogenous route in the absence of tumor exposure to conjunctival lymphatics, this study was undertaken to investigate the presence of lymphatic vessels in primary uveal melanomas. The...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2001-06, Vol.42 (7), p.1422-1428
Hauptverfasser:	Clarijs, Ruud, Schalkwijk, Lia, Ruiter, Dirk J, de Waal, Robert M. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast Neoplasms - blood supply Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - blood supply Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Endothelial Growth Factors - metabolism Humans Immunoenzyme Techniques Lymphatic System - metabolism Medical sciences Melanoma - blood supply Melanoma - metabolism Melanoma - pathology Neovascularization, Physiologic Ophthalmology Receptor Protein-Tyrosine Kinases - metabolism Receptors, Growth Factor - metabolism Receptors, Vascular Endothelial Growth Factor Skin Neoplasms - blood supply Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus Uveal Neoplasms - blood supply Uveal Neoplasms - metabolism Uveal Neoplasms - pathology Vascular Endothelial Growth Factor C Vascular Endothelial Growth Factor Receptor-3
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