Effects of inhibitors of guanine nucleotide synthesis on membrane potential and cytosolic free Ca2+ levels in insulin-secreting cells

Adenine nucleotides play an important role in the control of membrane potential by acting on ATP-sensitive K+ (K(ATP)) channels and, in turn, modulating the open probability of voltage-gated Ca2+ channels in pancreatic islet beta-cells. Here, we provide evidence that guanine nucleotides (GNs) also m...

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Veröffentlicht in:	Biochemical pharmacology 2000-03, Vol.59 (5), p.545-556
Hauptverfasser:	GUODONG LI, LUO, R.-H, METZ, S. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - metabolism Cell physiology Cells, Cultured Cricetinae Cytosol - drug effects Cytosol - physiology Diazoxide - pharmacology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Guanine Nucleotides - biosynthesis Guanine Nucleotides - physiology Insulin - metabolism Insulin Secretion Islets of Langerhans - cytology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Islets of Langerhans - physiology Membrane Potentials - drug effects Membrane Potentials - physiology Molecular and cellular biology Mycophenolic Acid - pharmacology Potassium Channel Blockers Potassium Channels - physiology Purine Nucleotides - metabolism Ribonucleosides - pharmacology Secretion. Exocytosis
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