Chromaffin-cell stimulation triggers fast millimolar mitochondrial Ca2+ transients that modulate secretion

Activation of calcium-ion (Ca2+) channels on the plasma membrane and on intracellular Ca2+ stores, such as the endoplasmic reticulum, generates local transient increases in the cytosolic Ca2+ concentration that induce Ca2+ uptake by neighbouring mitochondria. Here, by using mitochondrially targeted...

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Veröffentlicht in:	Nature cell biology 2000-02, Vol.2 (2), p.57-61
Hauptverfasser:	Montero, M, Alonso, M T, Carnicero, E, Cuchillo-Ibáñez, I, Albillos, A, García, A G, García-Sancho, J, Alvarez, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Adrenal Medulla - cytology Adrenal Medulla - metabolism Animals Biological Transport Caffeine Caffeine - pharmacology Calcium Calcium - metabolism Calcium Channels Calcium Signaling Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology Catecholamines - secretion Cattle Cell Membrane - metabolism Chromaffin cells Chromaffin Cells - cytology Chromaffin Cells - metabolism Clonazepam - analogs & derivatives Clonazepam - pharmacology Endoplasmic reticulum Endoplasmic Reticulum - metabolism Homeostasis Ions Membranes Mitochondria Mitochondria - metabolism Physiological aspects Potassium Potassium - pharmacology Ryanodine Receptor Calcium Release Channel - metabolism Sodium-Calcium Exchanger - antagonists & inhibitors Thiazepines - pharmacology
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