Carbachol effect on carotid body dopamine in vitro release in response to hypoxia in adult and pup rabbit

Dopamine (DA) release from the adult carotid body (CB) is dependent, in part, upon CB cholinergic receptor stimulation. The aim of the present study was to determine the role of cholinergic stimulation on DA release from rabbit pup CB with reference to adult's. CBs sampled from adult ( n=52) an...

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Veröffentlicht in:	Neuroscience research 2001-06, Vol.40 (2), p.183-188
Hauptverfasser:	Bairam, Aida, Néji, Habib, Kinkead, Richard, Marchal, François
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Acetylcholine Aging - physiology Animals Carbachol - pharmacology Carotid body Carotid Body - drug effects Carotid Body - growth & development Carotid Body - secretion Cholinergic Agonists - pharmacology Development Dopamine Dopamine - metabolism Dopamine - secretion Female Hypoxia Hypoxia - metabolism Hypoxia - physiopathology Male Norepinephrine - metabolism Oxygen - pharmacology Rabbit Rabbits Receptors, Cholinergic - drug effects Receptors, Cholinergic - metabolism
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Zusammenfassung:	Dopamine (DA) release from the adult carotid body (CB) is dependent, in part, upon CB cholinergic receptor stimulation. The aim of the present study was to determine the role of cholinergic stimulation on DA release from rabbit pup CB with reference to adult's. CBs sampled from adult ( n=52) and 10-day-old ( n=49) rabbits were incubated in vitro for 1 h in a surviving medium bubbled with either 100 or 8% O 2 in N 2, without (control) or in the presence of the cholinergic agonist carbachol 1 μM. In adults, DA released (DA r) in the medium was significantly larger with 1 μM carbachol compared with control in either 100 or 8% O 2 ( P
ISSN:	0168-0102 1872-8111
DOI:	10.1016/S0168-0102(01)00227-9