Novel Device to Change Left Ventricular Shape for Heart Failure Treatment: Device Design and Implantation Procedure
The Myocor Myosplint is designed to decrease left ventricular (LV) wall stress by changing LV shape, thus improving contractile function in dilated hearts. This shape change is accomplished by surgically placing three Myosplints perpendicular to the LV long axis, drawing the LV walls inward, and cre...
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| Veröffentlicht in: | ASAIO journal (1992) 2001-05, Vol.47 (3), p.244-248 |
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| container_title | ASAIO journal (1992) |
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| creator | Takagaki, Masami McCarthy, Patrick M Ochiai, Yoshie Dessoffy, Raymond Doi, Kazuyoshi Vidlund, Robert Mortier, Todd J Schweich, Cyril J Fukamachi, Kiyotaka |
| description | The Myocor Myosplint is designed to decrease left ventricular (LV) wall stress by changing LV shape, thus improving contractile function in dilated hearts. This shape change is accomplished by surgically placing three Myosplints perpendicular to the LV long axis, drawing the LV walls inward, and creating a symmetric, bilobular LV. Specially designed instruments aid in the precise delivery of these devices. The purpose of this study was to test the safety and feasibility of the procedure in dogs. Dilated cardiomyopathy was induced in 40 healthy dogs (26.3 ± 1.7 kg) by ventricular pacing at 230 beats per minute for an average of 25 ± 4 days. Using epicardial echocardiography, we placed the Myosplints across the LV chamber, avoiding the major coronary arteries, papillary muscles, and mitral valve. Once placed, the Myosplints were used to draw the LV walls inward to a prescribed distance. In all cases, we successfully implanted three Myosplints without using cardiopulmonary bypass. There were no complications related to the device or procedure. Myosplint implantation to change LV shape is safe and repeatable on a beating cardiomyopathic canine heart. Further study of the procedure will be needed in humans. |
| doi_str_mv | 10.1097/00002480-200105000-00017 |
| format | Article |
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This shape change is accomplished by surgically placing three Myosplints perpendicular to the LV long axis, drawing the LV walls inward, and creating a symmetric, bilobular LV. Specially designed instruments aid in the precise delivery of these devices. The purpose of this study was to test the safety and feasibility of the procedure in dogs. Dilated cardiomyopathy was induced in 40 healthy dogs (26.3 ± 1.7 kg) by ventricular pacing at 230 beats per minute for an average of 25 ± 4 days. Using epicardial echocardiography, we placed the Myosplints across the LV chamber, avoiding the major coronary arteries, papillary muscles, and mitral valve. Once placed, the Myosplints were used to draw the LV walls inward to a prescribed distance. In all cases, we successfully implanted three Myosplints without using cardiopulmonary bypass. There were no complications related to the device or procedure. Myosplint implantation to change LV shape is safe and repeatable on a beating cardiomyopathic canine heart. Further study of the procedure will be needed in humans.</description><identifier>ISSN: 1058-2916</identifier><identifier>EISSN: 1538-943X</identifier><identifier>DOI: 10.1097/00002480-200105000-00017</identifier><identifier>PMID: 11374766</identifier><identifier>CODEN: AJOUET</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Biological and medical sciences ; Cardiomyopathy, Dilated - diagnostic imaging ; Cardiomyopathy, Dilated - therapy ; Dogs ; Echocardiography ; Heart Failure - diagnostic imaging ; Heart Failure - therapy ; Heart-Assist Devices ; Medical sciences ; Prosthesis Design ; Prosthesis Implantation ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart</subject><ispartof>ASAIO journal (1992), 2001-05, Vol.47 (3), p.244-248</ispartof><rights>2001 Lippincott Williams & Wilkins, Inc.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4347-b7e6ac2357fc0b15ec28340f2243f943b7df4703e897133446b0e0dc023e64613</citedby><cites>FETCH-LOGICAL-c4347-b7e6ac2357fc0b15ec28340f2243f943b7df4703e897133446b0e0dc023e64613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00002480-200105000-00017$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4595,27901,27902,65206</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=976855$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11374766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takagaki, Masami</creatorcontrib><creatorcontrib>McCarthy, Patrick M</creatorcontrib><creatorcontrib>Ochiai, Yoshie</creatorcontrib><creatorcontrib>Dessoffy, Raymond</creatorcontrib><creatorcontrib>Doi, Kazuyoshi</creatorcontrib><creatorcontrib>Vidlund, Robert</creatorcontrib><creatorcontrib>Mortier, Todd J</creatorcontrib><creatorcontrib>Schweich, Cyril J</creatorcontrib><creatorcontrib>Fukamachi, Kiyotaka</creatorcontrib><title>Novel Device to Change Left Ventricular Shape for Heart Failure Treatment: Device Design and Implantation Procedure</title><title>ASAIO journal (1992)</title><addtitle>ASAIO J</addtitle><description>The Myocor Myosplint is designed to decrease left ventricular (LV) wall stress by changing LV shape, thus improving contractile function in dilated hearts. This shape change is accomplished by surgically placing three Myosplints perpendicular to the LV long axis, drawing the LV walls inward, and creating a symmetric, bilobular LV. Specially designed instruments aid in the precise delivery of these devices. The purpose of this study was to test the safety and feasibility of the procedure in dogs. Dilated cardiomyopathy was induced in 40 healthy dogs (26.3 ± 1.7 kg) by ventricular pacing at 230 beats per minute for an average of 25 ± 4 days. Using epicardial echocardiography, we placed the Myosplints across the LV chamber, avoiding the major coronary arteries, papillary muscles, and mitral valve. Once placed, the Myosplints were used to draw the LV walls inward to a prescribed distance. In all cases, we successfully implanted three Myosplints without using cardiopulmonary bypass. There were no complications related to the device or procedure. Myosplint implantation to change LV shape is safe and repeatable on a beating cardiomyopathic canine heart. Further study of the procedure will be needed in humans.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiomyopathy, Dilated - diagnostic imaging</subject><subject>Cardiomyopathy, Dilated - therapy</subject><subject>Dogs</subject><subject>Echocardiography</subject><subject>Heart Failure - diagnostic imaging</subject><subject>Heart Failure - therapy</subject><subject>Heart-Assist Devices</subject><subject>Medical sciences</subject><subject>Prosthesis Design</subject><subject>Prosthesis Implantation</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><issn>1058-2916</issn><issn>1538-943X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kdFOHCEUhklTU3XbV2hITLybCgMzML0zu1pNNmritukdYZiDOy0zrMBofHupu-pVSQiQfP858IEQpuQbJY04IXmUXJKiJISSKp-KPKn4gA5oxWTRcPb7Y96TShZlQ-t9dBjjn0xUjNFPaJ9SJrio6wMUr_wDOLyAh94ATh7P13q8A7wEm_AvGFPozeR0wLdrvQFsfcAXoEPC57p3UwC8CqDTkMHvr0UWEPu7Eeuxw5fDxukx6dT7Ed8Eb6DLmc9oz2oX4ctunaGf52er-UWxvP5xOT9dFoYzLopWQK1NySphDWlpBaaUjBNblpzZ_MJWdJYLwkA2gjLGed0SIJ0hJYOa15TN0PG27ib4-wliUkMfDbh8JfBTVIJImbU1GZRb0AQfYwCrNqEfdHhSlKh_wtWrcPUmXL0Iz9Gvux5TO0D3HtwZzsDRDtDRaGeDHk0f37hG1LKqMsW31KN3CUL866ZHCGoN2qW1-t93s2dIaJak</recordid><startdate>200105</startdate><enddate>200105</enddate><creator>Takagaki, Masami</creator><creator>McCarthy, Patrick M</creator><creator>Ochiai, Yoshie</creator><creator>Dessoffy, Raymond</creator><creator>Doi, Kazuyoshi</creator><creator>Vidlund, Robert</creator><creator>Mortier, Todd J</creator><creator>Schweich, Cyril J</creator><creator>Fukamachi, Kiyotaka</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200105</creationdate><title>Novel Device to Change Left Ventricular Shape for Heart Failure Treatment: Device Design and Implantation Procedure</title><author>Takagaki, Masami ; McCarthy, Patrick M ; Ochiai, Yoshie ; Dessoffy, Raymond ; Doi, Kazuyoshi ; Vidlund, Robert ; Mortier, Todd J ; Schweich, Cyril J ; Fukamachi, Kiyotaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4347-b7e6ac2357fc0b15ec28340f2243f943b7df4703e897133446b0e0dc023e64613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiomyopathy, Dilated - diagnostic imaging</topic><topic>Cardiomyopathy, Dilated - therapy</topic><topic>Dogs</topic><topic>Echocardiography</topic><topic>Heart Failure - diagnostic imaging</topic><topic>Heart Failure - therapy</topic><topic>Heart-Assist Devices</topic><topic>Medical sciences</topic><topic>Prosthesis Design</topic><topic>Prosthesis Implantation</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takagaki, Masami</creatorcontrib><creatorcontrib>McCarthy, Patrick M</creatorcontrib><creatorcontrib>Ochiai, Yoshie</creatorcontrib><creatorcontrib>Dessoffy, Raymond</creatorcontrib><creatorcontrib>Doi, Kazuyoshi</creatorcontrib><creatorcontrib>Vidlund, Robert</creatorcontrib><creatorcontrib>Mortier, Todd J</creatorcontrib><creatorcontrib>Schweich, Cyril J</creatorcontrib><creatorcontrib>Fukamachi, Kiyotaka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ASAIO journal (1992)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takagaki, Masami</au><au>McCarthy, Patrick M</au><au>Ochiai, Yoshie</au><au>Dessoffy, Raymond</au><au>Doi, Kazuyoshi</au><au>Vidlund, Robert</au><au>Mortier, Todd J</au><au>Schweich, Cyril J</au><au>Fukamachi, Kiyotaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel Device to Change Left Ventricular Shape for Heart Failure Treatment: Device Design and Implantation Procedure</atitle><jtitle>ASAIO journal (1992)</jtitle><addtitle>ASAIO J</addtitle><date>2001-05</date><risdate>2001</risdate><volume>47</volume><issue>3</issue><spage>244</spage><epage>248</epage><pages>244-248</pages><issn>1058-2916</issn><eissn>1538-943X</eissn><coden>AJOUET</coden><abstract>The Myocor Myosplint is designed to decrease left ventricular (LV) wall stress by changing LV shape, thus improving contractile function in dilated hearts. This shape change is accomplished by surgically placing three Myosplints perpendicular to the LV long axis, drawing the LV walls inward, and creating a symmetric, bilobular LV. Specially designed instruments aid in the precise delivery of these devices. The purpose of this study was to test the safety and feasibility of the procedure in dogs. Dilated cardiomyopathy was induced in 40 healthy dogs (26.3 ± 1.7 kg) by ventricular pacing at 230 beats per minute for an average of 25 ± 4 days. Using epicardial echocardiography, we placed the Myosplints across the LV chamber, avoiding the major coronary arteries, papillary muscles, and mitral valve. Once placed, the Myosplints were used to draw the LV walls inward to a prescribed distance. In all cases, we successfully implanted three Myosplints without using cardiopulmonary bypass. There were no complications related to the device or procedure. Myosplint implantation to change LV shape is safe and repeatable on a beating cardiomyopathic canine heart. Further study of the procedure will be needed in humans.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>11374766</pmid><doi>10.1097/00002480-200105000-00017</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | ASAIO journal (1992), 2001-05, Vol.47 (3), p.244-248 |
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| subjects | Animals Biological and medical sciences Cardiomyopathy, Dilated - diagnostic imaging Cardiomyopathy, Dilated - therapy Dogs Echocardiography Heart Failure - diagnostic imaging Heart Failure - therapy Heart-Assist Devices Medical sciences Prosthesis Design Prosthesis Implantation Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart |
| title | Novel Device to Change Left Ventricular Shape for Heart Failure Treatment: Device Design and Implantation Procedure |
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