The reliability of plain radiography in experimental fracture healing
To investigate the reliability of radiographs in the evaluation of healing of closed fractures. A closed midshaft tibial fracture was created in 40 goats and stabilized with an external fixator. The animals were assigned to four groups: no injection, injection of 1 mg osteogenic protein-1 (OP-1), 1...
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| Veröffentlicht in: | Skeletal radiology 2001-03, Vol.30 (3), p.151-156 |
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| creator | BLOKHUIS, T. J DE BRUINE, J. H. D BRAMER, J. A. M BOER, F. C BAKKER, F. C PATKA, P HAARMAN, H. J. Th. M MANOLIU, R. A |
| description | To investigate the reliability of radiographs in the evaluation of healing of closed fractures.
A closed midshaft tibial fracture was created in 40 goats and stabilized with an external fixator. The animals were assigned to four groups: no injection, injection of 1 mg osteogenic protein-1 (OP-1), 1 mg OP-1 with collagenous carrier, or carrier alone. Radiographs were performed weekly until the animals were killed after 2 and 4 weeks. Healing was evaluated using radiographs, biomechanical testing, and histological examination. All radiographs were examined by two independent observers. Interobserver agreement was calculated and radiographic scores were compared with mechanical and histological scores using regression analysis.
Regression analysis showed poor correlation between radiographic scores and biomechanical and histological data. Correlation coefficients varied between 0.39 and 0.63. Good agreement between the observers was seen in only three parameters: visibility of the fracture line, weightbearing ability, and a combined healing parameter.
Plain radiography provides poor parameters for monitoring the fracture healing process. |
| doi_str_mv | 10.1007/s002560000317 |
| format | Article |
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A closed midshaft tibial fracture was created in 40 goats and stabilized with an external fixator. The animals were assigned to four groups: no injection, injection of 1 mg osteogenic protein-1 (OP-1), 1 mg OP-1 with collagenous carrier, or carrier alone. Radiographs were performed weekly until the animals were killed after 2 and 4 weeks. Healing was evaluated using radiographs, biomechanical testing, and histological examination. All radiographs were examined by two independent observers. Interobserver agreement was calculated and radiographic scores were compared with mechanical and histological scores using regression analysis.
Regression analysis showed poor correlation between radiographic scores and biomechanical and histological data. Correlation coefficients varied between 0.39 and 0.63. Good agreement between the observers was seen in only three parameters: visibility of the fracture line, weightbearing ability, and a combined healing parameter.
Plain radiography provides poor parameters for monitoring the fracture healing process.</description><identifier>ISSN: 0364-2348</identifier><identifier>EISSN: 1432-2161</identifier><identifier>DOI: 10.1007/s002560000317</identifier><identifier>PMID: 11357453</identifier><identifier>CODEN: SKRADI</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Biomechanical Phenomena ; Biomechanics ; Bone Morphogenetic Protein 7 ; Bone Morphogenetic Proteins - therapeutic use ; External Fixators ; Female ; Fracture Fixation ; Fracture Healing ; Goats ; Injuries of the limb. Injuries of the spine ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Observer Variation ; Osteoarticular system. Muscles ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Radiography ; Regression Analysis ; Reproducibility of Results ; Tibia - physiology ; Tibial Fractures - diagnostic imaging ; Tibial Fractures - physiopathology ; Transforming Growth Factor beta ; Traumas. Diseases due to physical agents</subject><ispartof>Skeletal radiology, 2001-03, Vol.30 (3), p.151-156</ispartof><rights>2001 INIST-CNRS</rights><rights>International Skeletal Society 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-ad5c32b905157c4771ebe78accd6e510fe1662dca29e81218987c93ba90fab9d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=942095$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11357453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BLOKHUIS, T. J</creatorcontrib><creatorcontrib>DE BRUINE, J. H. D</creatorcontrib><creatorcontrib>BRAMER, J. A. M</creatorcontrib><creatorcontrib>BOER, F. C</creatorcontrib><creatorcontrib>BAKKER, F. C</creatorcontrib><creatorcontrib>PATKA, P</creatorcontrib><creatorcontrib>HAARMAN, H. J. Th. M</creatorcontrib><creatorcontrib>MANOLIU, R. A</creatorcontrib><title>The reliability of plain radiography in experimental fracture healing</title><title>Skeletal radiology</title><addtitle>Skeletal Radiol</addtitle><description>To investigate the reliability of radiographs in the evaluation of healing of closed fractures.
A closed midshaft tibial fracture was created in 40 goats and stabilized with an external fixator. The animals were assigned to four groups: no injection, injection of 1 mg osteogenic protein-1 (OP-1), 1 mg OP-1 with collagenous carrier, or carrier alone. Radiographs were performed weekly until the animals were killed after 2 and 4 weeks. Healing was evaluated using radiographs, biomechanical testing, and histological examination. All radiographs were examined by two independent observers. Interobserver agreement was calculated and radiographic scores were compared with mechanical and histological scores using regression analysis.
Regression analysis showed poor correlation between radiographic scores and biomechanical and histological data. Correlation coefficients varied between 0.39 and 0.63. Good agreement between the observers was seen in only three parameters: visibility of the fracture line, weightbearing ability, and a combined healing parameter.
Plain radiography provides poor parameters for monitoring the fracture healing process.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Bone Morphogenetic Protein 7</subject><subject>Bone Morphogenetic Proteins - therapeutic use</subject><subject>External Fixators</subject><subject>Female</subject><subject>Fracture Fixation</subject><subject>Fracture Healing</subject><subject>Goats</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Observer Variation</subject><subject>Osteoarticular system. Muscles</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Radiography</subject><subject>Regression Analysis</subject><subject>Reproducibility of Results</subject><subject>Tibia - physiology</subject><subject>Tibial Fractures - diagnostic imaging</subject><subject>Tibial Fractures - physiopathology</subject><subject>Transforming Growth Factor beta</subject><subject>Traumas. 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Injuries of the spine</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Observer Variation</topic><topic>Osteoarticular system. Muscles</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Radiography</topic><topic>Regression Analysis</topic><topic>Reproducibility of Results</topic><topic>Tibia - physiology</topic><topic>Tibial Fractures - diagnostic imaging</topic><topic>Tibial Fractures - physiopathology</topic><topic>Transforming Growth Factor beta</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BLOKHUIS, T. J</creatorcontrib><creatorcontrib>DE BRUINE, J. H. D</creatorcontrib><creatorcontrib>BRAMER, J. A. M</creatorcontrib><creatorcontrib>BOER, F. C</creatorcontrib><creatorcontrib>BAKKER, F. C</creatorcontrib><creatorcontrib>PATKA, P</creatorcontrib><creatorcontrib>HAARMAN, H. J. Th. 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J</au><au>DE BRUINE, J. H. D</au><au>BRAMER, J. A. M</au><au>BOER, F. C</au><au>BAKKER, F. C</au><au>PATKA, P</au><au>HAARMAN, H. J. Th. M</au><au>MANOLIU, R. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The reliability of plain radiography in experimental fracture healing</atitle><jtitle>Skeletal radiology</jtitle><addtitle>Skeletal Radiol</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>30</volume><issue>3</issue><spage>151</spage><epage>156</epage><pages>151-156</pages><issn>0364-2348</issn><eissn>1432-2161</eissn><coden>SKRADI</coden><abstract>To investigate the reliability of radiographs in the evaluation of healing of closed fractures.
A closed midshaft tibial fracture was created in 40 goats and stabilized with an external fixator. The animals were assigned to four groups: no injection, injection of 1 mg osteogenic protein-1 (OP-1), 1 mg OP-1 with collagenous carrier, or carrier alone. Radiographs were performed weekly until the animals were killed after 2 and 4 weeks. Healing was evaluated using radiographs, biomechanical testing, and histological examination. All radiographs were examined by two independent observers. Interobserver agreement was calculated and radiographic scores were compared with mechanical and histological scores using regression analysis.
Regression analysis showed poor correlation between radiographic scores and biomechanical and histological data. Correlation coefficients varied between 0.39 and 0.63. Good agreement between the observers was seen in only three parameters: visibility of the fracture line, weightbearing ability, and a combined healing parameter.
Plain radiography provides poor parameters for monitoring the fracture healing process.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11357453</pmid><doi>10.1007/s002560000317</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Biomechanical Phenomena Biomechanics Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - therapeutic use External Fixators Female Fracture Fixation Fracture Healing Goats Injuries of the limb. Injuries of the spine Investigative techniques, diagnostic techniques (general aspects) Medical sciences Observer Variation Osteoarticular system. Muscles Radiodiagnosis. Nmr imagery. Nmr spectrometry Radiography Regression Analysis Reproducibility of Results Tibia - physiology Tibial Fractures - diagnostic imaging Tibial Fractures - physiopathology Transforming Growth Factor beta Traumas. Diseases due to physical agents |
| title | The reliability of plain radiography in experimental fracture healing |
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