Depressive symptoms among cognitively normal versus cognitively impaired elderly subjects
Objectives The present cross‐sectional study analyzed the prevalence and severity of depressive symptoms among patients with Alzheimer's disease (DAT), vascular dementia (VAD), and among the cognitively normal elderly. Putative risk factors contributing to depression were likewise evaluated. Me...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2001-05, Vol.16 (5), p.455-461 |
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| container_title | International journal of geriatric psychiatry |
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| creator | Li, Yan-sheng Meyer, John S. Thornby, John |
| description | Objectives
The present cross‐sectional study analyzed the prevalence and severity of depressive symptoms among patients with Alzheimer's disease (DAT), vascular dementia (VAD), and among the cognitively normal elderly. Putative risk factors contributing to depression were likewise evaluated.
Methods
Seventy‐six DAT patients, 51 VAD patients, and 121 cognitively normal subjects were admitted to the study. Questionnaires concerning demography and their vascular and familial risk factors together with results of neuropsychological testing by combined Mini‐Mental Status Examinations (MMSE), Cognitive Capacity Screening Examinations (CCSE), and Hamilton Depression Rating Scales (HDRS) were obtained so that resulting data would be statistically analyzed.
Results
Prevalence of depressive symptoms among VAD, DAT, and cognitively normal elderly were 31.4%, 19.9%, and 13.2%, respectively. 25.5% of VAD and 13.2% of DAT patients had depression of mild to moderate degrees. Regression analysis revealed that diagnosis of VAD and DAT, heart disease, and past history of depression was significantly associated with high HDRS scores. There was no correlation between degree of depression and severity of cognitive impairments.
Conclusion
Mild to moderate depression is a common comorbidity with organic dementia, especially VAD, but associated depression is independent of severity of cognitive impairments. Copyright © 2001 John Wiley & Sons, Ltd |
| doi_str_mv | 10.1002/gps.360 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70879494</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21113022</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4100-38dcf936e60b549723a8df89023cd1055782f7ce5b1be281aa37c4f13d02bbb23</originalsourceid><addsrcrecordid>eNqF0NtqFTEUBuAgFrttxTeQAUEvZNocZnK4LFV3W4pWVMSrkMms2aTOyayZ6n77psympRfiVWCtj3-Fn5CXjB4xSvnxZsQjIekTsmLUmJwxKZ-SFdW6zCUXdJ88R7ymNO2Yfkb2GRNKFpKuyM_3MEZADDeQ4bYbp6HDzHVDv8n8sOnDlBbtNuuH2Lk2u4GIMz7ahG50IUKdQVtDTAOcq2vwEx6Svca1CC927wH5_vHDt9Oz_PLz-vz05DL3Rfp6LnTtGyMkSFqVhVFcOF032lAufM1oWSrNG-WhrFgFXDPnhPJFw0RNeVVVXByQN0vuGIffM-Bku4Ae2tb1MMxoFdXKFKb4L-Qs1UL5XeLbBfo4IEZo7BhD5-LWMmrv6rapbpvqTvLVLnKuOqgf3K7fBF7vgEPv2ia63ge8d8YIrk1S7xb1J7Sw_dc1u776uhzNFx1wgr_32sVfViqhSvvj09pemS-F5ObMXohb3GClcQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21113022</pqid></control><display><type>article</type><title>Depressive symptoms among cognitively normal versus cognitively impaired elderly subjects</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Li, Yan-sheng ; Meyer, John S. ; Thornby, John</creator><creatorcontrib>Li, Yan-sheng ; Meyer, John S. ; Thornby, John</creatorcontrib><description>Objectives
The present cross‐sectional study analyzed the prevalence and severity of depressive symptoms among patients with Alzheimer's disease (DAT), vascular dementia (VAD), and among the cognitively normal elderly. Putative risk factors contributing to depression were likewise evaluated.
Methods
Seventy‐six DAT patients, 51 VAD patients, and 121 cognitively normal subjects were admitted to the study. Questionnaires concerning demography and their vascular and familial risk factors together with results of neuropsychological testing by combined Mini‐Mental Status Examinations (MMSE), Cognitive Capacity Screening Examinations (CCSE), and Hamilton Depression Rating Scales (HDRS) were obtained so that resulting data would be statistically analyzed.
Results
Prevalence of depressive symptoms among VAD, DAT, and cognitively normal elderly were 31.4%, 19.9%, and 13.2%, respectively. 25.5% of VAD and 13.2% of DAT patients had depression of mild to moderate degrees. Regression analysis revealed that diagnosis of VAD and DAT, heart disease, and past history of depression was significantly associated with high HDRS scores. There was no correlation between degree of depression and severity of cognitive impairments.
Conclusion
Mild to moderate depression is a common comorbidity with organic dementia, especially VAD, but associated depression is independent of severity of cognitive impairments. Copyright © 2001 John Wiley & Sons, Ltd</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.360</identifier><identifier>PMID: 11376460</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Alzheimer Disease - psychology ; Biological and medical sciences ; Cognition ; Cognition Disorders - etiology ; Cognition Disorders - psychology ; Comorbidity ; Cross-Sectional Studies ; dementia ; Dementia, Vascular - psychology ; Depression ; Depression - epidemiology ; Depression - etiology ; depressive symptoms ; Female ; Geriatrics ; Humans ; Male ; Medical sciences ; Mood disorders ; Prevalence ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk Factors ; Severity of Illness Index ; Texas - epidemiology</subject><ispartof>International journal of geriatric psychiatry, 2001-05, Vol.16 (5), p.455-461</ispartof><rights>Copyright © 2001 John Wiley & Sons, Ltd.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 John Wiley & Sons, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4100-38dcf936e60b549723a8df89023cd1055782f7ce5b1be281aa37c4f13d02bbb23</citedby><cites>FETCH-LOGICAL-c4100-38dcf936e60b549723a8df89023cd1055782f7ce5b1be281aa37c4f13d02bbb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.360$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.360$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=993289$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11376460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yan-sheng</creatorcontrib><creatorcontrib>Meyer, John S.</creatorcontrib><creatorcontrib>Thornby, John</creatorcontrib><title>Depressive symptoms among cognitively normal versus cognitively impaired elderly subjects</title><title>International journal of geriatric psychiatry</title><addtitle>Int. J. Geriat. Psychiatry</addtitle><description>Objectives
The present cross‐sectional study analyzed the prevalence and severity of depressive symptoms among patients with Alzheimer's disease (DAT), vascular dementia (VAD), and among the cognitively normal elderly. Putative risk factors contributing to depression were likewise evaluated.
Methods
Seventy‐six DAT patients, 51 VAD patients, and 121 cognitively normal subjects were admitted to the study. Questionnaires concerning demography and their vascular and familial risk factors together with results of neuropsychological testing by combined Mini‐Mental Status Examinations (MMSE), Cognitive Capacity Screening Examinations (CCSE), and Hamilton Depression Rating Scales (HDRS) were obtained so that resulting data would be statistically analyzed.
Results
Prevalence of depressive symptoms among VAD, DAT, and cognitively normal elderly were 31.4%, 19.9%, and 13.2%, respectively. 25.5% of VAD and 13.2% of DAT patients had depression of mild to moderate degrees. Regression analysis revealed that diagnosis of VAD and DAT, heart disease, and past history of depression was significantly associated with high HDRS scores. There was no correlation between degree of depression and severity of cognitive impairments.
Conclusion
Mild to moderate depression is a common comorbidity with organic dementia, especially VAD, but associated depression is independent of severity of cognitive impairments. Copyright © 2001 John Wiley & Sons, Ltd</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - psychology</subject><subject>Biological and medical sciences</subject><subject>Cognition</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - psychology</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>dementia</subject><subject>Dementia, Vascular - psychology</subject><subject>Depression</subject><subject>Depression - epidemiology</subject><subject>Depression - etiology</subject><subject>depressive symptoms</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>Prevalence</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Texas - epidemiology</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0NtqFTEUBuAgFrttxTeQAUEvZNocZnK4LFV3W4pWVMSrkMms2aTOyayZ6n77psympRfiVWCtj3-Fn5CXjB4xSvnxZsQjIekTsmLUmJwxKZ-SFdW6zCUXdJ88R7ymNO2Yfkb2GRNKFpKuyM_3MEZADDeQ4bYbp6HDzHVDv8n8sOnDlBbtNuuH2Lk2u4GIMz7ahG50IUKdQVtDTAOcq2vwEx6Svca1CC927wH5_vHDt9Oz_PLz-vz05DL3Rfp6LnTtGyMkSFqVhVFcOF032lAufM1oWSrNG-WhrFgFXDPnhPJFw0RNeVVVXByQN0vuGIffM-Bku4Ae2tb1MMxoFdXKFKb4L-Qs1UL5XeLbBfo4IEZo7BhD5-LWMmrv6rapbpvqTvLVLnKuOqgf3K7fBF7vgEPv2ia63ge8d8YIrk1S7xb1J7Sw_dc1u776uhzNFx1wgr_32sVfViqhSvvj09pemS-F5ObMXohb3GClcQ</recordid><startdate>200105</startdate><enddate>200105</enddate><creator>Li, Yan-sheng</creator><creator>Meyer, John S.</creator><creator>Thornby, John</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200105</creationdate><title>Depressive symptoms among cognitively normal versus cognitively impaired elderly subjects</title><author>Li, Yan-sheng ; Meyer, John S. ; Thornby, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4100-38dcf936e60b549723a8df89023cd1055782f7ce5b1be281aa37c4f13d02bbb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - psychology</topic><topic>Biological and medical sciences</topic><topic>Cognition</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - psychology</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>dementia</topic><topic>Dementia, Vascular - psychology</topic><topic>Depression</topic><topic>Depression - epidemiology</topic><topic>Depression - etiology</topic><topic>depressive symptoms</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>Prevalence</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Texas - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yan-sheng</creatorcontrib><creatorcontrib>Meyer, John S.</creatorcontrib><creatorcontrib>Thornby, John</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yan-sheng</au><au>Meyer, John S.</au><au>Thornby, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depressive symptoms among cognitively normal versus cognitively impaired elderly subjects</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int. J. Geriat. Psychiatry</addtitle><date>2001-05</date><risdate>2001</risdate><volume>16</volume><issue>5</issue><spage>455</spage><epage>461</epage><pages>455-461</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><abstract>Objectives
The present cross‐sectional study analyzed the prevalence and severity of depressive symptoms among patients with Alzheimer's disease (DAT), vascular dementia (VAD), and among the cognitively normal elderly. Putative risk factors contributing to depression were likewise evaluated.
Methods
Seventy‐six DAT patients, 51 VAD patients, and 121 cognitively normal subjects were admitted to the study. Questionnaires concerning demography and their vascular and familial risk factors together with results of neuropsychological testing by combined Mini‐Mental Status Examinations (MMSE), Cognitive Capacity Screening Examinations (CCSE), and Hamilton Depression Rating Scales (HDRS) were obtained so that resulting data would be statistically analyzed.
Results
Prevalence of depressive symptoms among VAD, DAT, and cognitively normal elderly were 31.4%, 19.9%, and 13.2%, respectively. 25.5% of VAD and 13.2% of DAT patients had depression of mild to moderate degrees. Regression analysis revealed that diagnosis of VAD and DAT, heart disease, and past history of depression was significantly associated with high HDRS scores. There was no correlation between degree of depression and severity of cognitive impairments.
Conclusion
Mild to moderate depression is a common comorbidity with organic dementia, especially VAD, but associated depression is independent of severity of cognitive impairments. Copyright © 2001 John Wiley & Sons, Ltd</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>11376460</pmid><doi>10.1002/gps.360</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Aged Aged, 80 and over Alzheimer Disease - psychology Biological and medical sciences Cognition Cognition Disorders - etiology Cognition Disorders - psychology Comorbidity Cross-Sectional Studies dementia Dementia, Vascular - psychology Depression Depression - epidemiology Depression - etiology depressive symptoms Female Geriatrics Humans Male Medical sciences Mood disorders Prevalence Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors Severity of Illness Index Texas - epidemiology |
| title | Depressive symptoms among cognitively normal versus cognitively impaired elderly subjects |
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