Prosaptide D5 reverses hyperalgesia: inhibition of calcium channels through a pertussis toxin-sensitive G-protein mechanism in the rat

A retro-inverso 11-mer peptidomimetic of prosaposin, Prosaptide D5, induced neurite outgrowth in NS20Y neuroblastoma cells and enhanced [35S]GTPgammaS binding to rat synaptosomal membrane at low nanomolar concentrations similar to prosaposin. Intramuscular injection of D5 ameliorated thermal hyperal...

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Veröffentlicht in:	Neuroscience letters 2000-01, Vol.278 (1-2), p.120-122
Hauptverfasser:	Yan, L, Otero, D A, Hiraiwa, M, O'Brien, J S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axotomy - adverse effects Calcium - metabolism Calcium Channels - drug effects Calcium Channels - metabolism GTP-Binding Proteins - drug effects GTP-Binding Proteins - physiology Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Hyperalgesia - drug therapy Hyperalgesia - etiology Hyperalgesia - physiopathology Ion Channel Gating - drug effects Ion Transport - drug effects Male Nerve Growth Factors - pharmacology Nerve Growth Factors - therapeutic use Nerve Tissue Proteins - drug effects Nerve Tissue Proteins - physiology Neuralgia - complications Neuralgia - drug therapy Neuralgia - physiopathology Pertussis Toxin Rats Rats, Sprague-Dawley Reaction Time - drug effects Sciatic Nerve - injuries Synaptosomes - metabolism Virulence Factors, Bordetella - pharmacology
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