Maturation and Intranuclear Transport of Pre-Ribosomes Requires Noc Proteins

How pre-ribosomes temporally and spatially mature during intranuclear biogenesis is not known. Here, we report three nucleolar proteins, Noc1p to Noc3p, that are required for ribosome maturation and transport. They can be isolated in two distinct complexes: Noc1p/Noc2p associates with 90S and 66S pr...

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Veröffentlicht in:	Cell 2001-05, Vol.105 (4), p.499-509
Hauptverfasser:	Milkereit, Philipp, Gadal, Olivier, Podtelejnikov, Alexander, Trumtel, Stephanie, Gas, Nicole, Petfalski, Elisabeth, Tollervey, David, Mann, Mathias, Hurt, Ed, Tschochner, Herbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - physiology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Compartmentation - physiology Cell Nucleolus - metabolism Cytoplasm - metabolism Gene Expression Regulation, Fungal Genotype Green Fluorescent Proteins Heat-Shock Proteins - metabolism Indicators and Reagents - pharmacokinetics Intermediate Filament Proteins - metabolism Luminescent Proteins - pharmacokinetics Molecular Sequence Data Noc1 protein Noc2 protein Noc3 protein Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleocytoplasmic Transport Proteins Ribosomal Proteins - biosynthesis Ribosomal Proteins - metabolism Ribosomes - metabolism RNA Precursors - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Schizosaccharomyces Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Sequence Homology, Amino Acid
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