The Complement Regulator Factor H Binds to the Surface Protein OspE of Borrelia burgdorferi

Spirochete bacteria of the Borrelia burgdorferi sensu lato complex cause Lyme borreliosis. The three pathogenic subspecies Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi sensu stricto differ in their disease profiles and susceptibility to complement lysis. We investigated whether compl...

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Veröffentlicht in:	The Journal of biological chemistry 2001-03, Vol.276 (11), p.8427-8435
Hauptverfasser:	Hellwage, Jens, Meri, Taru, Heikkilä, Tero, Alitalo, Antti, Panelius, Jaana, Lahdenne, Pekka, Ilkka Seppälä, J.T., Meri, Seppo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Bacterial Bacterial Outer Membrane Proteins - metabolism Bacterial Proteins Binding Sites Blood Bactericidal Activity Blood Proteins - metabolism Borrelia burgdorferi Borrelia burgdorferi Group - immunology Borrelia garinii Complement C3b Inactivator Proteins Complement Factor H - chemistry Complement Factor H - metabolism factor H Heparin - pharmacology Humans Lipoproteins Microscopy, Fluorescence OspE protein Phagocytosis surface plasmon resonance Temperature
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