Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization

Replication-competent adenoviruses may provide a highly efficient means of delivering therapeutic genes to tumors. Previously, we evaluated in vitro a replication-competent adenovirus (Ad5-CD/TKrep) containing a cytosine deaminase (CD)/herpes simplex type 1 thymidine kinase (HSV-1 TK) fusion gene th...

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Veröffentlicht in:	Human gene therapy 2000, Vol.11 (1), p.67-76
Hauptverfasser:	ROGULSKI, K. R, WING, M. S, PAIELLI, D. L, GILBERT, J. D, JAE HO KIM, FREYTAG, S. O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - enzymology Adenoviridae - genetics Adenoviridae - physiology Adenovirus Animals Artificial Gene Fusion Biological and medical sciences Biotechnology Cell Survival Combined Modality Therapy Cytosine Deaminase Female Fundamental and applied biological sciences. Psychology Gene therapy Genetic Therapy Genetic Vectors Health. Pharmaceutical industry herpes simplex 1 Herpesvirus 1, Human - enzymology Industrial applications and implications. Economical aspects Injections, Intralesional Mice Mice, Nude Neoplasm Transplantation Neoplasms, Experimental - radiotherapy Neoplasms, Experimental - therapy Nucleoside Deaminases - genetics Radiation Tolerance Thymidine Kinase - genetics Virus Replication
Online-Zugang:	Volltext
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