A randomised phase II study on neo-adjuvant chemotherapy for ‘high-risk’ adult soft-tissue sarcoma

The aim of this study was to examine the strategy, feasibility and outcome of neo-adjuvant chemotherapy, with doxorubicin and ifosfamide, in adult patients with ‘high-risk’ soft-tissue sarcomas. Patients with ‘high-risk’ soft-tissue sarcomas, defined as tumours ⩾8 cm of any grade, or grade II/III tu...

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Veröffentlicht in:	European journal of cancer (1990) 2001-06, Vol.37 (9), p.1096-1103
Hauptverfasser:	Gortzak, E, Azzarelli, A, Buesa, J, Bramwell, V.H.C, van Coevorden, F, van Geel, A.N, Ezzat, A, Santoro, A, Oosterhuis, J.W, van Glabbeke, M, Kirkpatrick, A, Verweij, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy Chemotherapy, Adjuvant Combined Modality Therapy - methods Disease Progression Disease-Free Survival Doxorubicin - administration & dosage Follow-Up Studies Humans Ifosfamide - administration & dosage Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoadjuvant chemotherapy Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - surgery Pharmacology. Drug treatments Preoperative Care - methods Randomised study Risk Factors Sarcoma - drug therapy Sarcoma - radiotherapy Sarcoma - surgery Soft-tissue sarcoma Tumors
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Beschreibung
Zusammenfassung:	The aim of this study was to examine the strategy, feasibility and outcome of neo-adjuvant chemotherapy, with doxorubicin and ifosfamide, in adult patients with ‘high-risk’ soft-tissue sarcomas. Patients with ‘high-risk’ soft-tissue sarcomas, defined as tumours ⩾8 cm of any grade, or grade II/III tumours
ISSN:	0959-8049 1879-0852
DOI:	10.1016/S0959-8049(01)00083-1