Downregulation of CXCR-2 but not CXCR-1 expression by human keratinocytes by UVB

Interleukin‐8 (IL‐8) belongs to the CXC chemokine family. IL‐8 exerts its biological activities by binding to specific cell surface receptors, CXCR‐1 and CXCR‐2. Both receptors bind IL‐8 with high affinity but they have different affinities for MGSA/Groα and NAP‐2. It has been shown that the express...

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Veröffentlicht in:	Journal of cellular physiology 2000-03, Vol.182 (3), p.366-370
Hauptverfasser:	Kondo, Seiji, Yoneta, Akihiro, Yazawa, Hitoshi, Kamada, Asako, Jimbow, Kowichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - analysis Antigens, CD - genetics Cells, Cultured Down-Regulation - radiation effects Gene Expression - radiation effects Humans Immunoenzyme Techniques Keratinocytes - chemistry Keratinocytes - physiology Keratinocytes - radiation effects Receptors, Chemokine - analysis Receptors, Chemokine - genetics Receptors, Interleukin - analysis Receptors, Interleukin - genetics Receptors, Interleukin-8A Receptors, Interleukin-8B Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Skin - chemistry Skin - cytology Skin - radiation effects Ultraviolet Rays
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