GLUT4 is reduced in slow muscle fibers of type 2 diabetic patients: Is insulin resistance in type 2 diabetes a slow, type 1 fiber disease?

To gain further insight into the mechanisms underlying muscle insulin resistance, the influence of obesity and type 2 diabetes on GLUT4 immunoreactivity in slow and fast skeletal muscle fibers was studied. Through a newly developed, very sensitive method using immunohistochemistry combined with morp...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2001-06, Vol.50 (6), p.1324-1329
Hauptverfasser:	GASTER, Michael, STAEHR, Peter, BECK-NIELSEN, Henning, SCHRØDER, Henrick D, HANDBERG, Aase
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blood glucose Blood sugar Blotting, Western Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucose Transporter Type 4 Humans Insulin Insulin Resistance Male Medical sciences Middle Aged Monosaccharide Transport Proteins - metabolism Muscle Fibers, Fast-Twitch - metabolism Muscle Fibers, Slow-Twitch - metabolism Muscle Proteins Obesity - metabolism Physiological aspects Reference Values Striated muscle Type 2 diabetes
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