Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription

The p53-inducible gene PC3 (TIS21, BTG2) is endowed with antiproliferative activity. Here we report that expression of PC3 in cycling cells induced accumulation of hypophosphorylated, growth-inhibitory forms of pRb and led to G(1) arrest. This latter was not observed in cells with genetic disruption...

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Veröffentlicht in:	Molecular and cellular biology 2000-03, Vol.20 (5), p.1797
Hauptverfasser:	Guardavaccaro, D, Corrente, G, Covone, F, Micheli, L, D'Agnano, I, Starace, G, Caruso, M, Tirone, F
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Aspartic Acid Endopeptidases - genetics Cell Cycle - genetics Cyclin D1 - genetics G1 Phase - genetics Gene Expression Regulation Mice Proprotein Convertases Retinoblastoma Protein - genetics S Phase - genetics Transcription, Genetic Tumor Suppressor Protein p53 - genetics
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