Cytokine–cytokine interactions and the brain
Cytokine–cytokine interactions play a role in health and are crucial during immunological and inflammatory responses in disease. Cytokine interactions can result in additive, antagonist, or synergistic activities in maintaining physiological functions such as feeding, body temperature, and sleep, as...
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| Veröffentlicht in: | Brain Research Bulletin 2000, Vol.51 (1), p.3-9 |
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| container_title | Brain Research Bulletin |
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| creator | Turrin, Nicolas P Plata-Salamán, Carlos R |
| description | Cytokine–cytokine interactions play a role in health and are crucial during immunological and inflammatory responses in disease. Cytokine interactions can result in additive, antagonist, or synergistic activities in maintaining physiological functions such as feeding, body temperature, and sleep, as well as in anorectic, pyrogenic, and somnogenic neurological manifestations of acute and chronic disease. These interactions involve signaling homology, convergence of signaling pathways, and/or positive or negative feedbacks within and among cytokine systems. The interplay of cytokines with neurotransmitters, peptides/neuropeptides, and hormones also influence cytokine action in the brain. Interactive chemical cascades involving cytokines are consistent with the homeostatic physiological mechanisms and with the multi-humoral, pleiotropic, and redundant processes that occur during acute and chronic disease. |
| doi_str_mv | 10.1016/S0361-9230(99)00203-8 |
| format | Article |
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| ispartof | Brain Research Bulletin, 2000, Vol.51 (1), p.3-9 |
| issn | 0361-9230 1873-2747 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anorexia Biochemistry and metabolism Biological and medical sciences Brain - physiology Central nervous system Cytokines - physiology Disease Fever Fundamental and applied biological sciences. Psychology Growth factor Homeostasis Humans Interleukin Nervous system Neuroimmunology Neuropeptide Neurotransmitter Sleep Tumor necrosis factor Vertebrates: nervous system and sense organs |
| title | Cytokine–cytokine interactions and the brain |
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