Overexpression of MDR1 in an Intestinal Cell Line Results in Increased Cholesterol Uptake from Micelles

The multiple drug resistance protein, MDR1, is highly expressed on the apical surface of intestinal epithelial cells. The physiologic substrate of this protein remains unclear. Several studies using compounds known to act as MDR1 inhibitors have suggested that MDR1 may be involved in the transport o...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-01, Vol.267 (2), p.565-571
Hauptverfasser:	Tessner, Teresa G., Stenson, William F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological Transport, Active - drug effects Cell Line Cholesterol - metabolism Gene Expression Genes, MDR Humans Intestines - metabolism Micelles Rats Transfection Verapamil - pharmacology Vinblastine - metabolism
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