Effects of extracellular pH on the interaction of sipatrigine and lamotrigine with high-voltage-activated (HVA) calcium channels in dissociated neurones of rat cortex

Acidic extracellular pH reduced high-voltage-activated (HVA) currents in freshly isolated cortical pyramidal neurones of adult rats, shifting activation to more positive voltages ( V 1/2=−18 mV at pH 7.4, −11 mV at pH 6.4). Sipatrigine inhibited HVA currents, with decreasing potency at acidic pH (IC...

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Veröffentlicht in:	Neuropharmacology 2001-05, Vol.40 (6), p.784-791
Hauptverfasser:	Hainsworth, Atticus H., Spadoni, Francesca, Lavaroni, Franco, Giorgio Bernardi, Stefani, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	619C89 Activation Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Calcium Channel Blockers - pharmacology Calcium channels Calcium Channels - drug effects Calcium Channels - physiology Hydrogen-Ion Concentration Lamotrigine Male Medical sciences Neocortex - drug effects Neocortex - physiology Neurons - drug effects Neurons - physiology Neuropharmacology Neuroprotection Neuroprotective agent Neurotransmitter Uptake Inhibitors - pharmacology Pharmacology. Drug treatments Piperazines - pharmacology Pyrimidines - pharmacology Rats Rats, Wistar Sipatrigine Triazines - pharmacology
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