Incidence and recurrence rates of colorectal adenomas in first-degree asymptomatic relatives of patients with colon cancer
Subjects with one first-degree relative affected with colorectal cancer are considered to be at increased risk of colorectal adenomas. We compared the recurrence and incidence rates of colorectal adenomas among subjects with one first-degree relative with colorectal cancer and those without family h...
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| Veröffentlicht in: | The American journal of gastroenterology 2001-05, Vol.96 (5), p.1601-1604 |
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| container_title | The American journal of gastroenterology |
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| creator | Fossi, Stefania Bazzoli, Franco Ricciardiello, Luigi Nicolini, Gianni Zagari, Rocco Maurizio Pozzato, Paolo Palli, Domenico Roda, Enrico |
| description | Subjects with one first-degree relative affected with colorectal cancer are considered to be at increased risk of colorectal adenomas. We compared the recurrence and incidence rates of colorectal adenomas among subjects with one first-degree relative with colorectal cancer and those without family history. A series of consecutive asymptomatic subjects successfully underwent a colonoscopy, were found to have either normal results or at least one adenoma, provided a detailed family history, and were offered a second colonoscopy 3 yr later; 190 out of 436 subjects accepted, 134/172 with one or more adenomas and 56/264 with no abnormalities at the initial examination. A first-degree family history was reported by 43/134 and 26/56, respectively. By multivariate analysis, the presence of adenomas at follow-up examination was significantly associated with a positive family history of colorectal cancer in both subgroups, those with a previously resected adenoma (odds ratio = 2.23, 95% CI = 1.04–4.79) and those without (odds ratio = 8.95, CI = 1.29–62.22). A history of one first-degree relative with colorectal cancer is associated with a significant increase in 3-yr cumulative incidence and recurrence rates of adenomas. |
| doi_str_mv | 10.1111/j.1572-0241.2001.03784.x |
| format | Article |
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We compared the recurrence and incidence rates of colorectal adenomas among subjects with one first-degree relative with colorectal cancer and those without family history. A series of consecutive asymptomatic subjects successfully underwent a colonoscopy, were found to have either normal results or at least one adenoma, provided a detailed family history, and were offered a second colonoscopy 3 yr later; 190 out of 436 subjects accepted, 134/172 with one or more adenomas and 56/264 with no abnormalities at the initial examination. A first-degree family history was reported by 43/134 and 26/56, respectively. By multivariate analysis, the presence of adenomas at follow-up examination was significantly associated with a positive family history of colorectal cancer in both subgroups, those with a previously resected adenoma (odds ratio = 2.23, 95% CI = 1.04–4.79) and those without (odds ratio = 8.95, CI = 1.29–62.22). A history of one first-degree relative with colorectal cancer is associated with a significant increase in 3-yr cumulative incidence and recurrence rates of adenomas.</description><identifier>ISSN: 0002-9270</identifier><identifier>EISSN: 1572-0241</identifier><identifier>DOI: 10.1111/j.1572-0241.2001.03784.x</identifier><identifier>PMID: 11374706</identifier><language>eng</language><publisher>Oxford: .</publisher><subject>Adenoma - epidemiology ; Adenoma - genetics ; Adenoma - pathology ; Adenoma - surgery ; Aged ; Biological and medical sciences ; Colonoscopy ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Female ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local ; Odds Ratio ; Risk Factors ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>The American journal of gastroenterology, 2001-05, Vol.96 (5), p.1601-1604</ispartof><rights>All Rights Reserved.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3983-6fdc07bb48124a378c42c1937aa860f45ec3c49d2fe8b9d301d2b18b40e1cc1b3</citedby><cites>FETCH-LOGICAL-c3983-6fdc07bb48124a378c42c1937aa860f45ec3c49d2fe8b9d301d2b18b40e1cc1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=988569$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11374706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fossi, Stefania</creatorcontrib><creatorcontrib>Bazzoli, Franco</creatorcontrib><creatorcontrib>Ricciardiello, Luigi</creatorcontrib><creatorcontrib>Nicolini, Gianni</creatorcontrib><creatorcontrib>Zagari, Rocco Maurizio</creatorcontrib><creatorcontrib>Pozzato, Paolo</creatorcontrib><creatorcontrib>Palli, Domenico</creatorcontrib><creatorcontrib>Roda, Enrico</creatorcontrib><title>Incidence and recurrence rates of colorectal adenomas in first-degree asymptomatic relatives of patients with colon cancer</title><title>The American journal of gastroenterology</title><addtitle>Am J Gastroenterol</addtitle><description>Subjects with one first-degree relative affected with colorectal cancer are considered to be at increased risk of colorectal adenomas. We compared the recurrence and incidence rates of colorectal adenomas among subjects with one first-degree relative with colorectal cancer and those without family history. A series of consecutive asymptomatic subjects successfully underwent a colonoscopy, were found to have either normal results or at least one adenoma, provided a detailed family history, and were offered a second colonoscopy 3 yr later; 190 out of 436 subjects accepted, 134/172 with one or more adenomas and 56/264 with no abnormalities at the initial examination. A first-degree family history was reported by 43/134 and 26/56, respectively. By multivariate analysis, the presence of adenomas at follow-up examination was significantly associated with a positive family history of colorectal cancer in both subgroups, those with a previously resected adenoma (odds ratio = 2.23, 95% CI = 1.04–4.79) and those without (odds ratio = 8.95, CI = 1.29–62.22). A history of one first-degree relative with colorectal cancer is associated with a significant increase in 3-yr cumulative incidence and recurrence rates of adenomas.</description><subject>Adenoma - epidemiology</subject><subject>Adenoma - genetics</subject><subject>Adenoma - pathology</subject><subject>Adenoma - surgery</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Colonoscopy</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Recurrence, Local</subject><subject>Odds Ratio</subject><subject>Risk Factors</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Recurrence, Local</topic><topic>Odds Ratio</topic><topic>Risk Factors</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. 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We compared the recurrence and incidence rates of colorectal adenomas among subjects with one first-degree relative with colorectal cancer and those without family history. A series of consecutive asymptomatic subjects successfully underwent a colonoscopy, were found to have either normal results or at least one adenoma, provided a detailed family history, and were offered a second colonoscopy 3 yr later; 190 out of 436 subjects accepted, 134/172 with one or more adenomas and 56/264 with no abnormalities at the initial examination. A first-degree family history was reported by 43/134 and 26/56, respectively. By multivariate analysis, the presence of adenomas at follow-up examination was significantly associated with a positive family history of colorectal cancer in both subgroups, those with a previously resected adenoma (odds ratio = 2.23, 95% CI = 1.04–4.79) and those without (odds ratio = 8.95, CI = 1.29–62.22). A history of one first-degree relative with colorectal cancer is associated with a significant increase in 3-yr cumulative incidence and recurrence rates of adenomas.</abstract><cop>Oxford</cop><pub>.</pub><pmid>11374706</pmid><doi>10.1111/j.1572-0241.2001.03784.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenoma - epidemiology Adenoma - genetics Adenoma - pathology Adenoma - surgery Aged Biological and medical sciences Colonoscopy Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Female Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Humans Incidence Male Medical sciences Middle Aged Multivariate Analysis Neoplasm Recurrence, Local Odds Ratio Risk Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Incidence and recurrence rates of colorectal adenomas in first-degree asymptomatic relatives of patients with colon cancer |
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